Circulating Low -molecular Weight AGEs In The Development And Progression Of Diabetic Complications
Funder
National Health and Medical Research Council
Funding Amount
$297,523.00
Summary
High levels of sugars seen in patients with diabetes leads to damage of many organs including the heart, the eyes and the kidneys. These high sugars cause damage through a number of mechanisms, one being the formation of advanced glycation end products or AGEs, formed by the irreversible reaction between proteins and glucose. This reaction leads to a change in the shape and function of AGE-modified molecules that progressively contributes to organ damage. AGEs also bind and activate specific rec ....High levels of sugars seen in patients with diabetes leads to damage of many organs including the heart, the eyes and the kidneys. These high sugars cause damage through a number of mechanisms, one being the formation of advanced glycation end products or AGEs, formed by the irreversible reaction between proteins and glucose. This reaction leads to a change in the shape and function of AGE-modified molecules that progressively contributes to organ damage. AGEs also bind and activate specific receptors that promote the damage and scarring of tissue. Where the glucose concentration is high, AGEs accumulate much more quickly. This is one reason why patients with good sugar control do better than those who are unable to control their blood sugars. The importance of this AGE pathway is illustrated by the fact that blocking the formation of AGEs is able to prevent kidney damage in animals with diabetes. In addition, exposure to AGEs can cause diabetes-like changes in the absence of high sugars. Our laboratory is a world leader in the study of the advanced glycation and methods blocking this process. The research proposed will investigate circulating levels of AGEs in experimental animals and patients with diabetes, and correlate them with the development and progression of complications of diabetesRead moreRead less
Defining The Central Role Of Podocyte Depletion In The Development, Progression And Management Of Glomerular Disease
Funder
National Health and Medical Research Council
Funding Amount
$690,855.00
Summary
Podocytes are key cellular components of the kidney’s filtration barrier. Podocyte depletion (cell loss or injury) is a key event in most forms of kidney disease. We will investigate interactions between podocyte depletion and two major risk factors for kidney disease (diabetes and hypertension), assess whether podocyte depletion influences therapeutic outcomes, and commence efforts to develop podocyte-specific therapies.
Generating Endogenous Antigen Specific T Regulatory Cells To Treat Autoimmune MPO-ANCA GN
Funder
National Health and Medical Research Council
Funding Amount
$885,566.00
Summary
Glomerulonephritis (GN) is an inflammatory disease that affects the filtering organs (glomeruli) of the kidney. The most severe and aggressive form is ANCA-associated GN resulting from loss of tolerance to myeloperoxidase (MPO). Current therapies are toxic. This study will develop new strategies to restore immune tolerance to MPO thus treating patients with this disease. We will use an animal model to provide proof-of-concept that these novel therapies can treat MPO-ANCA associated GN.
Cardiovascular Disease; Priorities And Outcomes For People With Chronic And End Stage Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$81,976.00
Summary
This thesis will investigate the patterns, causes and effects of heart disease in chronic kidney disease patients; how heart disease impacts on hospital admission patterns and mortality over time. We will explore the relationship between cognition, cardiovascular and kidney disease; the impact on patient outcomes and quality of life. Finally, we will explore how current research funding reflects disease burden, research output and the stated priorities of patients with chronic kidney disease.
Implementing Innovative Trial Methodologies For Chronic Disease
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Chronic kidney disease and diabetes are associated with increased cardiovascular disease, hospitalisation and mortality. Health can be improved through better delivery of care. I plan to perform a population based study to identify people with kidney disease or diabetes who do are not receiving optimal care as described in current guidelines. From this, I plan to develop a trial to close the gap. I also plan to assess whether data linkage is an accurate method to conduct trial follow-up.
The SHARP-ER Study: Extended Follow-up Of The SHARP Study Cohort
Funder
National Health and Medical Research Council
Funding Amount
$1,106,265.00
Summary
The SHARP study, conducted from 2003 to 2010, recruited over 9,000 participants with kidney disease and showed, for the first time, that cholesterol-lowering was effective in preventing heart and vascular disease in people with advanced kidney disease. This study will extend follow-up to answers critical questions regarding long-term cardiovascular, renal and other health outcomes.
Growing The Evidence Base For Improved Outcomes In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
One in eight Australians has kidney disease, and is at increased risk of kidney failure, heart disease and stroke, and premature death. Despite this, very few treatments have been proven to be be effective at improving these outcomes. Professor Perkovic will undertake a suite of high-quality randomised trials and systematic reviews that will reliably identify new treatment approaches that will result in better quality and quantity of life for the millions of Australians affected by kidney diseas ....One in eight Australians has kidney disease, and is at increased risk of kidney failure, heart disease and stroke, and premature death. Despite this, very few treatments have been proven to be be effective at improving these outcomes. Professor Perkovic will undertake a suite of high-quality randomised trials and systematic reviews that will reliably identify new treatment approaches that will result in better quality and quantity of life for the millions of Australians affected by kidney diseaseRead moreRead less
Renal failure is a major cause of morbidity and mortality in persons with diabetes mellitus and accounts for the majority of renal disease worldwide. Renal fibrosis is the end result of progressive kidney disease. The proposed research aims to identify a new strategy by targeting specific channels in kidney cell membranes to arrest the development of enal fibrosis and hence progressive kidney disease caused by diabetes mellitus.
Vitamin D And Chronic Kidney Disease: The Effects On Mineral Metabolism, Vascular Calcification And Transplant Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$103,582.00
Summary
Kidney disease is a major health issue in the community. Vitamin D deficiency has been associated with an increased burden of cardiovascular disease and mortality in these patients. Vitamin D also has been shown to have a significant role in modulating our immune system. This study aims to assess the potential of vitamin D therapy to reduce the burden of cardiovascular disease and its effects on the immune function of renal transplant recipients in the laboratory and clinical setting.