Studying Coronary Physiology Within Human Coronary Arteries Using Computational Fluid Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$383,834.00
Summary
The aim of this project is to combine the recent technological advances within the individual fields of coronary physiology, three-dimensional coronary angiography, and computational fluid dynamics to develop a novel method to calculate realistic coronary blood flow. This technique will provide a simple and clinically applicable method to measure physiological parameters such as microcirculatory resistance and shear stress within _live� human coronary arteries.
Advancing The Epidemiology Of Coronary Heart Disease: Reliable Monitoring, Secondary Prevention And Future Projections
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Coronary heart disease imposes a significant health care burden in Australia, and there have been major changes to the way in which this disease is diagnosed and treated. This project will develop a new method for accurate monitoring of the burden of coronary heart disease nationally, will assess the effectiveness of current drug treatments for people with coronary heart disease and estimate future rates of coronary heart disease in the whole population.
Evaluating Coronary Stents Using High-resolution Optical Coherence Tomography Imaging In Patients With Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
A stent is a device made of metal that is placed inside an artery to prop it. Recently, the applicant introduced into Australia a novel technology to examine these stents once inside the body. This information may help make stents safer for patients
Plasma Metabolomic Profiling Of Patients With Serial Coronary Atheroma Progression For Predicting Myocardial Infarction And Death
Funder
National Health and Medical Research Council
Funding Amount
$373,114.00
Summary
Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new ag ....Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new agent that dramatically lowers cholesterol.Read moreRead less
Improving Early Recognition And Response To Symptoms In Acute Cardiovascular Events.
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
An important challenge facing cardiovascular public health is to improve access to treatment for acute events, like heart attacks and stroke, by improving public recognition and the initial response to symptoms. This research aims to extend the current understanding and to evaluate existing and test new interventions in this area. Outcomes from this research will inform the development of future campaigns and interventions aiming to improve symptom recognition and reduce delays in presenting to ....An important challenge facing cardiovascular public health is to improve access to treatment for acute events, like heart attacks and stroke, by improving public recognition and the initial response to symptoms. This research aims to extend the current understanding and to evaluate existing and test new interventions in this area. Outcomes from this research will inform the development of future campaigns and interventions aiming to improve symptom recognition and reduce delays in presenting to hospital for acute cardiovascular events.Read moreRead less
The Role Of New Generation Multidetector Row CT For Identification And Management Of Vulnerable Plaque At Risk Of Acute Coronary Syndrome : A Prospective Observational And Interventional Study
Funder
National Health and Medical Research Council
Funding Amount
$189,326.00
Summary
Heart attack remains one of the major cause of death. This is usually due to rupture of a plaque (due to cholesterol buildup) in the major heart arteries. Studies using invasive ultrasound have identified some features of plaque that are at high risk of rupture. These plaques are referred to as "vulnerable plaque". Recent developments in the computed tomography (CT) technology which is a non-invasive technique has enabled us to also identify these features. However thus far, no prospective large