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Microvascular Function And Outcome In Patients With Acute Coronary Syndromes
Funder
National Health and Medical Research Council
Funding Amount
$79,514.00
Summary
Damage to the small vessels of the heart is a hallmark of heart attacks. Furthermore, small vessel dysfunction (MVD) is associated with a worse prognosis even in the presence of an unblocked major coronary artery following a heart attack. Using novel invasive assessments, we aim to analyse the prevalence and clinical predictors of MVD, assess the impact of MVD on short and long-term outcome after heart attack and address the impact of new treatments on MVD and heart muscle recovery.
The Access Project - Assessment Of Coronary Artery Disease Using CT Effectively For Stable Symptoms
Funder
National Health and Medical Research Council
Funding Amount
$754,369.00
Summary
Invasive Coronary Angiography (ICA) provides x-ray visualisation of coronary disease (CAD) that is essential for coronary surgery/balloon angioplasty. However many patients undergo this procedure without requiring these therapies despite the associated severe complications. The ACCESS Project screens patients scheduled for ICA, identifying those unlikely to have CAD and referring them for non-invasive CT angiography. This strategy reduces procedure complications and result in major cost savings.
Studying Coronary Physiology Within Human Coronary Arteries Using Computational Fluid Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$383,834.00
Summary
The aim of this project is to combine the recent technological advances within the individual fields of coronary physiology, three-dimensional coronary angiography, and computational fluid dynamics to develop a novel method to calculate realistic coronary blood flow. This technique will provide a simple and clinically applicable method to measure physiological parameters such as microcirculatory resistance and shear stress within _live� human coronary arteries.
This study is testing two drugs in people having heart surgery, to see whether either can reduce serious complications such as heart attack, stroke or death. Aspirin thins the blood and can reduce these risks but it increases bleeding during surgery. Another drug can reduce bleeding, but it may counteract the benefits of aspirin. The study is being done at more than 20 hospitals in Australia and around the world.
Examining GWAS-identified Loci Of Interest In Predicting Coronary Events In Subjects With Known Coronary Heart Disease: The LIPID Genetic Study
Funder
National Health and Medical Research Council
Funding Amount
$649,940.00
Summary
Can modern genetic analysis identify the genes which predict future heart attacks? We will follow up 4337 patients who have already suffered a heart attack and use the findings from the exciting new technique of GWAS (Gene wide association studies) to study their whole genetic map, select gene markers from thousands of possibilities to identify those at highest risk. This will develop a genetic markers of risk and shed light on previously unsuspected mechanisms of heart disease.
Evaluating Coronary Stents Using High-resolution Optical Coherence Tomography Imaging In Patients With Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
A stent is a device made of metal that is placed inside an artery to prop it. Recently, the applicant introduced into Australia a novel technology to examine these stents once inside the body. This information may help make stents safer for patients
Heart Failure And Its Antecedents: Pathophysiology, Prevention And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$9,061,084.00
Summary
Heart failure is mainly a result of coronary artery disease. It is a major cause of disability and mortality in Australia and is projected to increase markedly over the next two decades. This program brings together clinical and basic science expertise to address aspects of the prevention and control of coronary disease and heart failure. The outcomes that will arise will provide a better understanding of the mechanisms involved in the progression from stable heart disease to failure.
In Vivo Evaluation Of Coronary Atheroma Burden And Its Association With Focal Coronary Endothelial Function
Funder
National Health and Medical Research Council
Funding Amount
$123,736.00
Summary
Heart attacks remain the leading cause of death in the western world. It has been recently identified that the burden of plaque buildup in the coronary arteries is a major predictor of future heart attacks. Furthermore, it also known that impaired relaxation within the coronary arteries also increases the future risk of heart attacks. The dynamic relationship between these two critical factors remains unknown and an understanding of this is important for predicting future heart attacks.