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Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels ....Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels, reducing material and manufacturing costs without compromise to safety and performance - an immense benefit for the myriad engineered products or structures that feature flow over a deformable surface. Read moreRead less
Taming turbulence: Hydrodynamic stability and flow-structure interaction using grid-free computation. Turbulence is characterized as seemingly disordered fluctuations that impede the progress of an object through a fluid by creating increased frictional or drag forces. Using a new type of fluid-flow simulation, this project will generate advanced understanding of turbulence in the flow over the surface of a vehicle, be it a ship, car, aircraft or within a pipe, with the technological objective o ....Taming turbulence: Hydrodynamic stability and flow-structure interaction using grid-free computation. Turbulence is characterized as seemingly disordered fluctuations that impede the progress of an object through a fluid by creating increased frictional or drag forces. Using a new type of fluid-flow simulation, this project will generate advanced understanding of turbulence in the flow over the surface of a vehicle, be it a ship, car, aircraft or within a pipe, with the technological objective of reducing drag by adhering a compliant skin to the surface. While the correct choice of compliance relies upon understanding very complex flow-structure dynamics, the resulting technology is simple, robust and has low capital and maintenance costs. Clearly, drag reduction reduces fuel costs and lower fuel consumption is environmentally beneficial. Read moreRead less
Assessing the determinants and consequences of safety climate in the maritime industry. This project will examine the predictors and outcomes of safety climate in the Australian maritime industry. Findings from this project will be used to improve safety policies, regulations and practices that aim to minimise the number of accidents and incidents in Australian waters.
DEVELOPMENT OF NEW NONLINEAR CONTROLLERS FOR TRAJECTORY TRACKING AND PATH-FOLLOWING OF UNDERACTUATED OCEAN VEHICLES. Trajectory tracking control and path-following of underactuated ocean vehicles are not only of theoretical challenging but also important practice. This project is firstly to develop methodologies to design full-state feedback controllers to force the underactuated ocean vehicles including surface ships and underwater vehicles with off-diagonal terms in their system matrices to tr ....DEVELOPMENT OF NEW NONLINEAR CONTROLLERS FOR TRAJECTORY TRACKING AND PATH-FOLLOWING OF UNDERACTUATED OCEAN VEHICLES. Trajectory tracking control and path-following of underactuated ocean vehicles are not only of theoretical challenging but also important practice. This project is firstly to develop methodologies to design full-state feedback controllers to force the underactuated ocean vehicles including surface ships and underwater vehicles with off-diagonal terms in their system matrices to track reference trajectories generated by virtual vehicles, and to follow a predefined path with a desired forward speed. Secondly, we develop methods to design observers to estimate the unmeasured states (velocities) of the vehicles and incorporate with the full-state feedback controllers to have output-feedback observer-based controllers. Lastly, the proposed control design methods are extended to a certain class of underactuated mechanical systems.Read moreRead less
In the Driver's seat: role of trace elements in enabling crustal fluid flow. This proposal aims to systematically investigate the role of trace elements in controlling the kinetics, product composition, and feed-back between fluid flow and the reaction interface, in fluid-driven mineral reactions. This project expects to provide a framework for the integration of activator trace elements in models of crustal fluid flow and their application in the recovery of base, precious, and critical metals, ....In the Driver's seat: role of trace elements in enabling crustal fluid flow. This proposal aims to systematically investigate the role of trace elements in controlling the kinetics, product composition, and feed-back between fluid flow and the reaction interface, in fluid-driven mineral reactions. This project expects to provide a framework for the integration of activator trace elements in models of crustal fluid flow and their application in the recovery of base, precious, and critical metals, using interdisciplinary approaches across geochemistry, mineral engineering and material sciences. Expected outcomes include improved prediction of the transport of metals and fluids in geo-systems. This should provide significant benefits towards integrating the mineral value chain from exploration to mining and metallurgy.Read moreRead less
Where to find giant porphyry and epithermal gold and copper deposits. This project will determine when and where giant gold or copper deposits should form, consolidating links with Indonesia, and using South East Asia as a vast natural laboratory in which to examine the effect of large-scale tectonic processes. The project will produce a four-dimensional virtual exploration toolkit to show how to apply the methods.
Developing a new tectonothermal and mineralization history for the Capricorn Orogen, Western Australia: Assisting mineral exploration in greenfields terrains. Successful exploration models rely on the development of a reliable geological framework through which to understand the specific processes responsible for the formation of economic ore deposits. A framework cannot be constructed without robust age data. This Project will apply advanced geochronology, combined with regional- and deposit-sc ....Developing a new tectonothermal and mineralization history for the Capricorn Orogen, Western Australia: Assisting mineral exploration in greenfields terrains. Successful exploration models rely on the development of a reliable geological framework through which to understand the specific processes responsible for the formation of economic ore deposits. A framework cannot be constructed without robust age data. This Project will apply advanced geochronology, combined with regional- and deposit-scale field mapping, to formulate a new and improved stratigraphic and tectonic framework for a prospective greenfields region in Western Australia. Outcomes from this Project will lead to more effective exploration models and thereby better exploration targeting. Reducing uncertainty and risk in exploration is key to the discovery and development of deep Earth resources. Read moreRead less
Experimental constraints on the genesis of gold-rich ore deposits. The project will provide a new set of tools to explore for gold-rich ore deposits in Australia and globally. By integrating geochemical studies with cutting-edge experiments carried out at three Australian universities in strategic partnership with industry, the outcomes of this project will provide much needed knowledge to predict the locations of large gold-rich deposits that are concealed beneath vast expanses of the Australia ....Experimental constraints on the genesis of gold-rich ore deposits. The project will provide a new set of tools to explore for gold-rich ore deposits in Australia and globally. By integrating geochemical studies with cutting-edge experiments carried out at three Australian universities in strategic partnership with industry, the outcomes of this project will provide much needed knowledge to predict the locations of large gold-rich deposits that are concealed beneath vast expanses of the Australian continent. The new results will translate into smarter exploration practice, significantly enhancing success in targeting ore deposits that are rich in high-value metal and display the smallest have a small environmental footprint, to underpin the sustainability of our nation into the future.
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Role Of Transition Metal Ions And Redox Activity In The Development Of Atherosclerotic Plaques
Funder
National Health and Medical Research Council
Funding Amount
$196,018.00
Summary
Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability ....Metal ions such as iron and copper have been reproted to be present in the lesions present in diseased human arteries and it has been suggested that these metal ions contribute to the development of atherosclerosis (hardening of the arteries) via their ability to catalyse the formation of highly reactive molecualr fragments called free radicals. Though metal ions are known to catalyse such reactions in test-tube experiments, both the presence of metal ions in diseased arteries and their ability to generate free radicals is controversial. This study will employ a novel, minimally-invasive, technique to assess the nature and quantity of metal ions present in well-defined human and animal lesions at different stages of lesion development. The ability of these metal ions to catalyse free radical formation from components present in the artery wall will also be assessed. The release of these metal ions from the artery wall to added organic molecules will be assessed as this might minimise their potential to cause damage, and provide a possible therapeutic strategy. These studies will therefore provide valuable information as to the significance and role of reactive metal ions in the development of human artery disease and the possible prevention, or minimisation, of such processes.Read moreRead less
IMPACTS OF TRANSIT LED DEVELOPMENT IN A NEW RAIL CORRIDOR. Impacts of transit-oriented development (TOD) in precincts adjoining the new Perth-Mandurah railway will be addressed by longitudinal survey. Results of a revealed preference questionnaire about actual trips will be combined with a stated choice questionnaire. Aims are to quantify the effects of TOD on rail and car use and on daily activities, new railway services on the travel behaviour of households near new station precincts, differin ....IMPACTS OF TRANSIT LED DEVELOPMENT IN A NEW RAIL CORRIDOR. Impacts of transit-oriented development (TOD) in precincts adjoining the new Perth-Mandurah railway will be addressed by longitudinal survey. Results of a revealed preference questionnaire about actual trips will be combined with a stated choice questionnaire. Aims are to quantify the effects of TOD on rail and car use and on daily activities, new railway services on the travel behaviour of households near new station precincts, differing accessibility of station precincts on household travel patterns, improved accessibility on economic activity and employment. Replacement of car-trips by walking and cycling, changes in shopping & leisure activities & the effect of trip-chaining on number of trips are of particular interest.Read moreRead less