Obesity and insulin resistance are an escalating health problem in Australian adolescents. Unmanaged, they are likely to progress to type 2 diabetes and early atherosclerosis and which may pose a major burden on health care resources. However, treatment strategies are currently limited because of the lack of evidence. This PhD research aims to identify, summarise and test an effective and evidence-based approach of dietary management for overweight/obese adolescents and older children with clini ....Obesity and insulin resistance are an escalating health problem in Australian adolescents. Unmanaged, they are likely to progress to type 2 diabetes and early atherosclerosis and which may pose a major burden on health care resources. However, treatment strategies are currently limited because of the lack of evidence. This PhD research aims to identify, summarise and test an effective and evidence-based approach of dietary management for overweight/obese adolescents and older children with clinical insulin resistance or prediabetes.Read moreRead less
Bisphosphonate Therapy With Zoledronate Or Tenofovir Switching To Improve Low Bone Mineral Density In HIV-Infected Adults: A Strategic, Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$716,300.00
Summary
Most HIV+ Australians receive tenofovir, a ‘preferred’ drug in all HIV treatment guidelines, and may do for decades, as HIV therapy is lifelong and because there are very few new HIV drugs. 40% of HIV+ adults have low bone density and HIV+ adults experience more fractures. Of all HIV drugs, tenofovir causes the most bone loss. This trial compares two approaches: a drug to improve bone density and switching tenofovir to another drug. This ‘treat versus switch’ approach is a world-first for HIV.
Cystic Fibrosis - Insulin Deficiency, Early Action (CF-IDEA)
Funder
National Health and Medical Research Council
Funding Amount
$185,485.00
Summary
Cystic Fibrosis (CF) is the most common life-threatening genetic condition affecting Australian children. As well as repeated lung infections, children with CF develop insulin deficiency and eventually diabetes. The CF-IDEA trial (Cystic Fibrosis – Insulin Deficiency, Early Action) will determine whether starting insulin treatment before the onset of diabetes (earlier than current practice) will improve the health of children with CF by improving body weight and lung function.