Periodontal Disease And Chronic Kidney Disease Among Aboriginal Adults; An RCT
Funder
National Health and Medical Research Council
Funding Amount
$1,035,550.00
Summary
Chronic Kidney Disease is a growing public health concern in Australia, especially among Aboriginal populations. It is associated with progression to end stage kidney disease requiring dialysis, cardiovascular disease burden and high mortality. This study will use a randomised controlled trial design to determine if comprehensive periodontal therapy reduces progression of kidney disease among Aboriginal adults with chronic kidney disease residing in Central Australia.
Treatment Of Invasively Ventilated Adults With Early Activity And Mobilisation
Funder
National Health and Medical Research Council
Funding Amount
$1,467,137.00
Summary
The sickest patients in intensive care units (ICUs) receive prolonged, invasive support for their breathing. This is currently managed with complete bed rest, and results in severe muscle weakness, increased duration of hospital stay and poor recovery. We have found that early activity and mobilisation during invasive breathing support is safe and may improve survival and recovery. We will test early activity and mobilisation in a large randomised controlled trial of 750 ICU patients.
The N-ICE Trial: A Randomised Controlled Trial Of The Safety And Efficacy Of N-Acetyl Cysteine (NAC) As A Pharmacotherapy For Methamphetamine (“ice”) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,551,368.00
Summary
Crystalline methamphetamine (aka ‘ice’) is a significant public health concern in Australia and globally. Currently there are no approved medications to treat methamphetamine dependence. We will trial tN-acetyl-cysteine (NAC) as a medications for methamphetamine dependence.
A Randomised Trial Of A Clinical Prediction Tool For Targeting Depression Care (Target-D)
Funder
National Health and Medical Research Council
Funding Amount
$944,774.00
Summary
The Target-D Study uses a novel clinical prediction tool to test a new approach to depression care in general practice based upon sub-grouping patients into low, medium and high risk of ongoing depression. Participants will be randomly allocated to targeted treatments based upon their risk profile or to usual general practice care. We will measure whether the new approach results in greater improvements in depressive symptoms, quality of life and functioning and whether there are cost benefits.
A Randomised Controlled Trial To Improve Depression In Family Carers Through A Physical Activity Intervention
Funder
National Health and Medical Research Council
Funding Amount
$727,745.00
Summary
This RCT of a physical activity intervention for carers and care recipients aims to determine whether physical activity (designed for carer and care recipient to do together) can reduce depression in older carers. The intervention includes a physiotherapist assessment, Otago and Otago-Plus exercise programs in carer/care recipient’s home over six-months. An economic evaluation will be undertaken. If successful, the intervention could be broadly applied within the carer support service system.
A Randomised Controlled Trial Of Cognitive Bias Modification Training During Early Recovery From Alcohol Dependence
Funder
National Health and Medical Research Council
Funding Amount
$531,685.00
Summary
Relapse to alcohol dependence often occurs within days of detoxification, partly because alcohol-dependent people are easily triggered to approach alcohol-related cues. Computerised “brain-training” programs may reduce this “approach bias”, reducing risk of relapse. We aim to conduct a multi-site trial testing the effects of this training on alcohol relapse, and to estimate the savings to the health care system that could be achieved by conducting this treatment during inpatient detoxification.
Venesection Or Expectant Management For Moderate Iron Overload In HFE Related Hereditary Haemochromatosis
Funder
National Health and Medical Research Council
Funding Amount
$853,109.00
Summary
Haemochromatosis is a preventable genetic iron overload disorder. Untreated, it can shorten life due mainly to liver cirrhosis and cancer. It can be prevented by blood donation to maintain normal iron levels. It is unclear, however, whether treatment is necessary when individuals have moderate elevation of iron in the body. This research project will study the effects of treatment in this group by assessing a number of scans, questionnaires and blood tests in treated and untreated individuals.
Ketamine Therapy Among Patients With Treatment-resistant Depression: A Randomised, Double-blind, Placebo-controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,069,382.00
Summary
In the last decade, there have been reports of powerful antidepressant effects after a single injection of anaesthetic ketamine, with dramatic (though shortlasting) effects within 24 hours. This will be the first controlled study to test whether a course of repeated ketamine treatments, given over 4 weeks, is effective and safe in treating depression.
The Arthroplasty Surgical Antibiotic Prophylaxis (ASAP) Study
Funder
National Health and Medical Research Council
Funding Amount
$3,509,985.00
Summary
The demand for total joint replacement surgery will double over the next decade. Infection involving the surgical wound is a devastating complication of this surgery. Half of all infections are due to methicillin resistant Staphylococcus (such as MRSA) and Enterococcus. This multicentre randomised controlled trial aims to investigate whether the addition of vancomycin at the time of surgery reduces the incidence of surgical wound infections; is safe and is cost-effective.
Stroke is a medical emergency. Admission to a stroke unit; administration of clot busting therapy to eligible patients; and treatment of fever, raised blood sugar and swallowing difficulties are therapies with demonstrated evidence to reduce death and disability. Our study will rigorously evaluate an organisational intervention to deliver these initiatives in Emergency Departments. We hypothesise this will deliver further significant improvements in 90-day health outcomes and patient recovery.