The origins, global spread and evolution of novel honey bee parasites. This project aims to study how emergent diseases arise, spread and evolve, studying varroa mites – a parasite of honey bees that will inevitably arrive in Australia and is expected to damage agriculture and the environment. As the mites have a well-characterised native range, independent host switches and a well-documented history of spread, they make good models. Mites have evolved after invasion, although without significan ....The origins, global spread and evolution of novel honey bee parasites. This project aims to study how emergent diseases arise, spread and evolve, studying varroa mites – a parasite of honey bees that will inevitably arrive in Australia and is expected to damage agriculture and the environment. As the mites have a well-characterised native range, independent host switches and a well-documented history of spread, they make good models. Mites have evolved after invasion, although without significant genetic differentiation at neutral markers. This project aims to identify genetic mechanisms associated with the host switches; reconstruct the pattern and demography of varroa’s global spread; and determine how selection acted on the mites after the host switch.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100685
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Historical pest genomes inform debate about how rapid evolution proceeds. This project plans to compare the genomes of archived and contemporary specimens to discover how two key Australian pest moths have adapted to insecticides, aiding prediction of how they may respond in the future. Agricultural pest species are often capable of rapid adaptation to insecticides, resulting in widespread genetic resistance. Does this resistance build on existing genetic variation, or are fresh mutations used t ....Historical pest genomes inform debate about how rapid evolution proceeds. This project plans to compare the genomes of archived and contemporary specimens to discover how two key Australian pest moths have adapted to insecticides, aiding prediction of how they may respond in the future. Agricultural pest species are often capable of rapid adaptation to insecticides, resulting in widespread genetic resistance. Does this resistance build on existing genetic variation, or are fresh mutations used to produce a fast adaptive response? How do adaptive strategies differ among key Australian pests? This project aims to answer these questions and advance understanding of mechanisms that underpin rapid evolution to improve approaches toward pest management and agricultural protection.Read moreRead less
Defining the evolution of pathogen virulence to enhance rabbit biocontrol. Rabbits impose a major economic and ecological burden on Australia. Biocontrols involving viruses are the best means to regulate rabbit populations, although they often have transient effectiveness. It is therefore essential to determine why some viruses retain the high virulence essential for effective biocontrol, while others are consistently benign. Through bioinformatic and experimental studies of two rabbit viruses w ....Defining the evolution of pathogen virulence to enhance rabbit biocontrol. Rabbits impose a major economic and ecological burden on Australia. Biocontrols involving viruses are the best means to regulate rabbit populations, although they often have transient effectiveness. It is therefore essential to determine why some viruses retain the high virulence essential for effective biocontrol, while others are consistently benign. Through bioinformatic and experimental studies of two rabbit viruses with markedly different virulence, Rabbit Haemorrhagic Disease virus (high virulence) and Australian rabbit calicivirus (low virulence), this project will determine the molecular mechanisms that control virulence and the factors that shape virulence evolution. Ultimately, this research will help improve rabbit biocontrol in Australia.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL100100183
Funder
Australian Research Council
Funding Amount
$2,168,370.00
Summary
Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virule ....Biological adaptation under natural and anthropogenic conditions. This project covers all four national priority areas. Nature abounds with conflicts between what is good for the individual or a larger entity (a population, a society, or a species). Researching them will explain why populations adapt or fail to adapt to novel conditions (e.g., climate change) and predict when interventions are beneficial. Similar rules govern the spread of invasive species. Even health problems, e.g., new virulent strains of human, animal or plant diseases, require such evolutionary thinking. Cutting-edge mathematical tools also prepare Australians for an era in the near future where genomic data are so cheap to acquire that training in complex mathematical and logical analysis becomes a factor limiting scientific progress.Read moreRead less