Impact Of Beta Adrenergic Antagonsim On Energy Metabolism And Body Composition
Funder
National Health and Medical Research Council
Funding Amount
$118,557.00
Summary
Beta-blockers are drugs commonly used to treat high blood pressure, anxiety, migraines and irregular heart rhythms. They work by blocking the action of chemical messengers called catecholamines which increase metabolic rate, fat utilisation and heart function. The aim is to determine whether ?-blockers impair metabolic function of the body which may lead to obesity and a loss of fitness. Judicious use of these medications and consideration of alternatives may lead to better health outcomes.
This project will test the proposal that rising follicle-stimulating hormone (FSH) levels in ageing females directly accelerate reproductive failure and bone loss , major public health issues due to delayed childbearing and our rising ageing population. We have developed a unique mouse model with elevated FSH levels that cause premature female infertility. We will now use this model to determine the direct effects of high FSH upon ovarian and uterine function, as well as bone loss with age.