Metabolic And Molecular Basis Of Embryo Signalling
Funder
National Health and Medical Research Council
Funding Amount
$409,836.00
Summary
Cells in the body are powered by mitochondria that essentially generate the energy required for development. This grant will determine how the environment affects the mitochondria in the developing embryo and determine the impacts to the embryo and pregnancy if a mitochondria is partially shut down.
Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
Clinical Review Of A Cohort Aged 22-33 Years Conceived Using Assisted Reproductive Technologies
Funder
National Health and Medical Research Council
Funding Amount
$946,454.00
Summary
In a recent study, using telephone-interviews, we compared the health and wellbeing of 547 singleton young adults born following assisted reproductive technologies (ART), with 549 matched controls. Reviewing their health when they are 22-33 years is possible because of their ongoing interest. We have a protocol in place to measure their cardiac and respiratory function and other aspects of growth and development. Our findings will fill a major knowledge gap about the longer term safety of ART.
Effective software vulnerability detection for web services. This project aims to design and implement new and better methods to find vulnerabilities in software services delivered over the web or through the cloud, as well as methods for proving the absence of certain types of vulnerability. So-called injection attacks are pervasive and generally considered the most important security threat on today's Internet. The programming languages used for software services tend to use strings as a unive ....Effective software vulnerability detection for web services. This project aims to design and implement new and better methods to find vulnerabilities in software services delivered over the web or through the cloud, as well as methods for proving the absence of certain types of vulnerability. So-called injection attacks are pervasive and generally considered the most important security threat on today's Internet. The programming languages used for software services tend to use strings as a universal data structure, which unfortunately makes it hard to separate trusted code from untrusted user-provided data. This project intends to develop novel program analysis tools and string constraint solvers, and employ these tools to support sophisticated automated reasoning about string manipulating software.Read moreRead less
Domain-specific visual languages for big data analytics applications. This project aims to invent domain-specific visual languages and support model-driven engineering based infrastructure so domain experts can specify, generate and apply complex data analytics and visualisation techniques. Many domains, including intelligent transport, business intelligence, and population health, need more effective “big data” analytics and visualisation. A challenge is to combine detailed domain knowledge – w ....Domain-specific visual languages for big data analytics applications. This project aims to invent domain-specific visual languages and support model-driven engineering based infrastructure so domain experts can specify, generate and apply complex data analytics and visualisation techniques. Many domains, including intelligent transport, business intelligence, and population health, need more effective “big data” analytics and visualisation. A challenge is to combine detailed domain knowledge – what the data means and what it can be used for – with sophisticated, scalable computational techniques to mine and present information from the huge volumes of raw data. This project is expected to improve productivity and quality of big data analytics and visualisation in critical domains.Read moreRead less
Metamorphic slices and their applications in fault localization. The main purpose of this project is to enhance the quality of software. The expected outcomes include the delivery of new cost-effective methods to debug software, and the extension of current debugging methods to be applicable in wider contexts.
Self Discovery, Self Configuration and Self Healing of Enterprise Grids. Firstly, the project will assist the elevation of grid computing into mainstream computing, and by this provide a direct response to some problems identified by the working party on the Australia's ICT research and research training. Secondly, our country is an excellent consumer of IT technology. But, it needs software artifacts that could be sold. A set of proposed services will be a saleable commodity of great commercial ....Self Discovery, Self Configuration and Self Healing of Enterprise Grids. Firstly, the project will assist the elevation of grid computing into mainstream computing, and by this provide a direct response to some problems identified by the working party on the Australia's ICT research and research training. Secondly, our country is an excellent consumer of IT technology. But, it needs software artifacts that could be sold. A set of proposed services will be a saleable commodity of great commercial value. A software company that will develop its commercial version could be set up. Thirdly, the project will help Early Career Researchers in gaining an experience necessary to carry out independent research and assist in training new researchers: Postdocs, PhDs and Masters.Read moreRead less
Integration of Metamorphic Testing and Model Checking. This project proposes an innovative approach of integrating metamorphic testing and model checking. Its main outcome will be to deliver a comprehensive testing method that will help to reduce errors and costs in software development and consequently to improve the quality of software systems. Since software is pervasive and ubiquitous, our results will improve the nation's software productivity and quality. Thus, our results will help in ra ....Integration of Metamorphic Testing and Model Checking. This project proposes an innovative approach of integrating metamorphic testing and model checking. Its main outcome will be to deliver a comprehensive testing method that will help to reduce errors and costs in software development and consequently to improve the quality of software systems. Since software is pervasive and ubiquitous, our results will improve the nation's software productivity and quality. Thus, our results will help in raising our nation's competitive advantage towards the goal of becoming a leading nation in the software industry among Asia-Pacific countries. Furthermore, this collaboration will help young Australian researchers to link to the Chinese Academy of Sciences, a leading-edge international research institute.Read moreRead less
Metamorphic Testing: An In-Depth Study to Enhance the Failure-Detection Capability of Software Testing Without an Oracle. Nowadays, software is pervasive and ubiquitous. It plays a significant role in the daily lives of all kinds of people. The Australian software industry has bloomed in recent years. Our research results will improve the cost-effectiveness of software development, thereby upgrading the nation's software productivity and quality. These factors are conducive to the export of soft ....Metamorphic Testing: An In-Depth Study to Enhance the Failure-Detection Capability of Software Testing Without an Oracle. Nowadays, software is pervasive and ubiquitous. It plays a significant role in the daily lives of all kinds of people. The Australian software industry has bloomed in recent years. Our research results will improve the cost-effectiveness of software development, thereby upgrading the nation's software productivity and quality. These factors are conducive to the export of software produced by Australians and helpful in raising our nation's competitive advantage towards the goal of becoming a leading nation in the software industry among Asia-Pacific countries.Read moreRead less