Treatment for skin cancer costs the Australian healthcare system >$1 billion annually. Early detection and accurate diagnosis of melanoma improves survival, however a standardised approach to diagnosis does not currently exist. This study will prospectively recruit 15,000 patients to develop and validate a risk stratified image-based approach to melanoma prevention, early detection and surveillance which will incorporate cutting edge technologies to standardise diagnosis and optimise care.
Shannon Entropy Mapping -AF Ablation From First Principles
Funder
National Health and Medical Research Council
Funding Amount
$263,503.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disorder in humans, and a rapidly growing epidemic in Australia. AF occurs because electrical circuits called rotors take over the top chambers of the heart. Until now, ablation procedures to target AF have not been able to specifically target rotors, which has meant operations are often long and arduous. This project uses new mathematical techniques we have developed to localise rotors driving AF, aiming to develop a faster safer and more ....Atrial fibrillation (AF) is the most common heart rhythm disorder in humans, and a rapidly growing epidemic in Australia. AF occurs because electrical circuits called rotors take over the top chambers of the heart. Until now, ablation procedures to target AF have not been able to specifically target rotors, which has meant operations are often long and arduous. This project uses new mathematical techniques we have developed to localise rotors driving AF, aiming to develop a faster safer and more effective AF ablation.Read moreRead less
Shannon Entropy Mapping - AF Ablation From First Principles
Funder
National Health and Medical Research Council
Funding Amount
$439,589.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disorder in humans, and a rapidly growing epidemic in Australia. AF occurs because electrical circuits called rotors take over the top chambers of the heart. Until now, ablation procedures to target AF have not been able to specifically target rotors, which has meant operations are often long and arduous. This project uses new mathematical techniques we have developed to localise rotors driving AF, aiming to develop a faster safer and more ....Atrial fibrillation (AF) is the most common heart rhythm disorder in humans, and a rapidly growing epidemic in Australia. AF occurs because electrical circuits called rotors take over the top chambers of the heart. Until now, ablation procedures to target AF have not been able to specifically target rotors, which has meant operations are often long and arduous. This project uses new mathematical techniques we have developed to localise rotors driving AF, aiming to develop a faster safer and more effective AF ablation.Read moreRead less
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Novel Bioinformatics Methods For Prioritizing Disease-causing INDELs
Funder
National Health and Medical Research Council
Funding Amount
$351,664.00
Summary
This project will build a bioinformatics diagnostic tool for the detection of small insertions and deletions (INDELs) in the human genome, which are the second most abundant class of human genetic variations. INDELs are implicated in many human diseases. Thus, the assessment of INDELs is critical for understanding disease etiology, disease susceptibility, and for interpreting personal genome sequencing data. The goal is to improve disease diagnosis and prevention.
Infrared Spectroscopic Imaging In The Diagnosis Of Cervical Cancer
Funder
National Health and Medical Research Council
Funding Amount
$291,600.00
Summary
In Victoria alone around 500000 Pap smears a year are examined for evidence of cancer of the cervix or conditions that may lead to cancer. This is a time consuming, labour intensive and costly process with a relatively high failure rate. A number of alternative techniques have been explored in the last decade with a view to providing a diagnostic technique that is free of human error, more reliable than the Pap method and easily used. An alternative technique based on using infrared light to pro ....In Victoria alone around 500000 Pap smears a year are examined for evidence of cancer of the cervix or conditions that may lead to cancer. This is a time consuming, labour intensive and costly process with a relatively high failure rate. A number of alternative techniques have been explored in the last decade with a view to providing a diagnostic technique that is free of human error, more reliable than the Pap method and easily used. An alternative technique based on using infrared light to probe smears shows promise in providing such an easily automated reliable method. We, and others have spent a number of years exploring this technique and have solved a number of the problems associated with it. Based on our work in the field and the work of others we now wish to develop a methodology using an infrared micro-imaging spectrometer combined with multivariate statistics that can be used to diagnose cervical cancer and the conditions that lead to cervical cancer.Read moreRead less
There are new genetic technologies on the horizon that will influence decision-making about testing in pregnancy for fetal abnormality and also create a greater need for communication of important genetic information in families. Two areas of my research will focus on these issues. I will also examine how the interaction between genes and the environment during pregnancy, specifically in relation to alcohol use and assisted reproduction, impacts on offspring health and development