Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries ....Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries designed to correct movement abnormalities in these patients. Realistic computer simulations of human movement can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Advanced control and estimation strategies for electromechanical brake-by-wire systems. The project aims to investigate the application of advanced control and estimation techniques (robust nonlinear and soft-computing approaches) to the problem of maximising the effectiveness of electromechanical brake-by-wire systems in emergency braking manoeuvres. The work will be conducted using state-of-the-art control design and hardware-in-the loop simulation facilities in the Research Centre for Advance ....Advanced control and estimation strategies for electromechanical brake-by-wire systems. The project aims to investigate the application of advanced control and estimation techniques (robust nonlinear and soft-computing approaches) to the problem of maximising the effectiveness of electromechanical brake-by-wire systems in emergency braking manoeuvres. The work will be conducted using state-of-the-art control design and hardware-in-the loop simulation facilities in the Research Centre for Advanced By-Wire Technologies (RABiT), which has been established to accelerate the development and commercialisation of by-wire technology in Australia. Expected outcomes are actuator and road friction control algorithms which have been demonstrated to be robust in the context of real-world actuator and vehicle dynamics.Read moreRead less
Analysis and design of control systems with saturation and time-delay. Control engineering is an enabling technology without which most modern engineering systems, such as aircrafts or Internet, can not operate properly. Actuator saturation and time-delays are undesirable phenomena that often arise in control systems leading to poor performance and sometimes instability. For example, both of these phenomena arise in control of modern telecommunication systems, such as Active Queue Management in ....Analysis and design of control systems with saturation and time-delay. Control engineering is an enabling technology without which most modern engineering systems, such as aircrafts or Internet, can not operate properly. Actuator saturation and time-delays are undesirable phenomena that often arise in control systems leading to poor performance and sometimes instability. For example, both of these phenomena arise in control of modern telecommunication systems, such as Active Queue Management in TCP networks. The project aims at tackling these phenomena by using recently developed techniques in antiwindup for saturating actuators and by revisiting some classical methods for Smith predictor design for time-delayed systems.Read moreRead less
Fractional dynamic models for MRI to probe tissue microstructure. This project aims to develop new mathematical tools for mapping tissue microstructural properties via the use of space-time fractional calculus methods. In magnetic resonance imaging, mathematical models and their parameters play a key role in associating information between images and biology, with the overall aim of producing spatially resolved maps of tissue property variations. However, models which can inform on changes in mi ....Fractional dynamic models for MRI to probe tissue microstructure. This project aims to develop new mathematical tools for mapping tissue microstructural properties via the use of space-time fractional calculus methods. In magnetic resonance imaging, mathematical models and their parameters play a key role in associating information between images and biology, with the overall aim of producing spatially resolved maps of tissue property variations. However, models which can inform on changes in microscale tissue properties are lacking. The tools developed by this project will be used to generate new magnetic resonance image based maps to convey information on tissue microstructure changes in the human brain. Additionally, the mathematical tools developed will be transferable to other applications where diffusion and transport in heterogeneous porous media play a role.Read moreRead less
Channel Assignment in Cellular Communication Systems and Optical Networks. Due to the rapid growth in mobile communications, efficient management of the scarce radio spectrum has emerged as an important issue. To avoid interference various conditions need to be satisfied by channels assigned to the transmitters in a cellular communication network. This project targets optimal assignments under such constraints, and similar problems for optical networks. Its implementation will have potential app ....Channel Assignment in Cellular Communication Systems and Optical Networks. Due to the rapid growth in mobile communications, efficient management of the scarce radio spectrum has emerged as an important issue. To avoid interference various conditions need to be satisfied by channels assigned to the transmitters in a cellular communication network. This project targets optimal assignments under such constraints, and similar problems for optical networks. Its implementation will have potential applications in computer and telecommunication industries, and advance significantly our knowledge on relevant subjects of mathematics and operations research. Read moreRead less
Finite-dimensional Sampled-data Control of Nonlinear Spatially Distributed Parameter Systems. Optical communication networks, smart materials and fluid flows, are all examples of systems whose behaviour can be significantly improved by automatic control. These are identified as some of the key technologies that will shape our future. This project will contribute to the fundamental science and engineering design of such diverse systems. Two postdoctoral fellows and one graduate student will be t ....Finite-dimensional Sampled-data Control of Nonlinear Spatially Distributed Parameter Systems. Optical communication networks, smart materials and fluid flows, are all examples of systems whose behaviour can be significantly improved by automatic control. These are identified as some of the key technologies that will shape our future. This project will contribute to the fundamental science and engineering design of such diverse systems. Two postdoctoral fellows and one graduate student will be trained in this important emerging field.Read moreRead less
Neurobiological computation using self organization. Despite their phenomenal power and speed there are many simple things that computers still cannot do, that humans, and indeed many animals, are able to perform effortlessly. The research outlined in this proposal aims to develop new, biologically inspired, computational approaches that attempt to bridge this gap. This research will help place Australia, despite its relatively small size, as a leading research community in the development of ....Neurobiological computation using self organization. Despite their phenomenal power and speed there are many simple things that computers still cannot do, that humans, and indeed many animals, are able to perform effortlessly. The research outlined in this proposal aims to develop new, biologically inspired, computational approaches that attempt to bridge this gap. This research will help place Australia, despite its relatively small size, as a leading research community in the development of the next wave of computing devices. The development of new and "more natural" approaches to computing will deliver large dividends to a range of social, economic and environmental problems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668549
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Major upgrade of the computing hardware and software for the widely used BioManager bioinformatic service. ANGIS has been an Australian national facility for bioinformatics since 1991, now with over 4000 users across 150 university schools or departments, government departments, hospitals and research institutes. The grant will provide the computer upgrade and software support needed to handle the enormous increases in database size and complexity and expand the service into new areas of bioinfo ....Major upgrade of the computing hardware and software for the widely used BioManager bioinformatic service. ANGIS has been an Australian national facility for bioinformatics since 1991, now with over 4000 users across 150 university schools or departments, government departments, hospitals and research institutes. The grant will provide the computer upgrade and software support needed to handle the enormous increases in database size and complexity and expand the service into new areas of bioinformatics. Bioinformatics is critical to much of modern biology, and the improvements will enhance research and data analysis in many areas of research, leveraging more value from the research being undertaken by users. Read moreRead less
Analysis and Design of Networked Control Systems. Drive-by-wire cars, fly-by-wire aircraft and sensor/actuator wireless networks in process and manufacturing industries are just a few examples of emerging networked control technologies that are currently reshaping our world. These technological advances have a vast potential to reduce the cost, weight and volume of engineered systems, simplify their maintenance and installation and their novel architectures and features may enable us to address ....Analysis and Design of Networked Control Systems. Drive-by-wire cars, fly-by-wire aircraft and sensor/actuator wireless networks in process and manufacturing industries are just a few examples of emerging networked control technologies that are currently reshaping our world. These technological advances have a vast potential to reduce the cost, weight and volume of engineered systems, simplify their maintenance and installation and their novel architectures and features may enable us to address significant environmental and socio-economic challenges, such as an increased demand for energy and other limited resources. This project will develop a systematic design methodology for networked control systems that will be essential in ensuring that its full potential is exploited.Read moreRead less
Phylodynamics for Single Cell Genomics . This project generates the mathematical framework required to look at single cell data in developmental systems and tissues. All cells in a multi-cellular organism derive from a single ancestral cell, generally the fertilised egg cell. Phylodynamics provides a framework to analyse and model this data, by connecting the shared ancestry of cells in an organism to the cell population and tissue dynamics. By developing the mathematical and statistical foundat ....Phylodynamics for Single Cell Genomics . This project generates the mathematical framework required to look at single cell data in developmental systems and tissues. All cells in a multi-cellular organism derive from a single ancestral cell, generally the fertilised egg cell. Phylodynamics provides a framework to analyse and model this data, by connecting the shared ancestry of cells in an organism to the cell population and tissue dynamics. By developing the mathematical and statistical foundations for the analysis of single cell data in a phylodynamic framework we will establish a powerful new computational tools for the analysis of tissues and developmental processes. Read moreRead less