ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Rare Event Simulation with Heavy Tails. The project provides a rigorous way to enhance our understanding of the mechanisms that bring about catastrophic rare events such as urban flooding, electricity shortages and financial bankrupcy. Australia is at the forefront of exciting recent developments in rare event simulation. The advancement of the knowledge in this area will generate a competitive advantage for various sections of the Australian industry, including the areas of industrial reliabili ....Rare Event Simulation with Heavy Tails. The project provides a rigorous way to enhance our understanding of the mechanisms that bring about catastrophic rare events such as urban flooding, electricity shortages and financial bankrupcy. Australia is at the forefront of exciting recent developments in rare event simulation. The advancement of the knowledge in this area will generate a competitive advantage for various sections of the Australian industry, including the areas of industrial reliability, finance and insurance, were accurate simulation techniques are becoming increasingly important.Read moreRead less
Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a com ....Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a competitive advantage for various sections of the Australian industry, including telecommunications, biotechnology and finance. The project will enable Australian researchers to continue to work at the forefront of this fast moving and exciting area of international research.Read moreRead less
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less
Computer simulation to study emergence of material texture in the Earth and Plate Tectonics. Plate tectonics has played a crucial role in the evolution and dynamics of the earth impacting on the diversity of life, mineralisation, and crustal dynamics. Despite its significance, how and under what conditions material texture and plate tectonics emerge from a proto-planet is not well understood. New computational methodologies to simulate the evolution of the plate-mantle system will be used to stu ....Computer simulation to study emergence of material texture in the Earth and Plate Tectonics. Plate tectonics has played a crucial role in the evolution and dynamics of the earth impacting on the diversity of life, mineralisation, and crustal dynamics. Despite its significance, how and under what conditions material texture and plate tectonics emerge from a proto-planet is not well understood. New computational methodologies to simulate the evolution of the plate-mantle system will be used to study how the upper mantle emerges as a thermo-mechanically distinct boundary layer, how this emergent structure relates to anisotropy in the upper mantle, and how it is affected by cross-scale effects controlling fault zone behaviour and crustal dynamics.Read moreRead less
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Quantum Information and Entanglement: a new framework for Science and Technology with quantum many-body systems. The expected outcome of the research program is a significant boost in the understanding of quantum many-body systems, which will reinforce Australia's competitiveness and international profile in aspects of breakthrough science and frontier technologies. By developing both the underpinning theory and innovative computational tools, and by applying them to problems of recognised impor ....Quantum Information and Entanglement: a new framework for Science and Technology with quantum many-body systems. The expected outcome of the research program is a significant boost in the understanding of quantum many-body systems, which will reinforce Australia's competitiveness and international profile in aspects of breakthrough science and frontier technologies. By developing both the underpinning theory and innovative computational tools, and by applying them to problems of recognised importance, this program will have direct implications in areas of condensed matter physics, quantum statistical mechanics, particle physics, complex systems, quantum information science and technology, quantum computation, engineered quantum systems and nanotechnology. Read moreRead less
Coarse Grained Parallel Algorithms. Various fields of research face barriers created by problems that are computationally hard and/or require processing of large amounts of data. For example, some computational biochemistry methods on protein or gene sequences can not be scaled up to data sets required for human health research because of performance problems. Parallel computing enables new research by increasing the size of solvable problems. In addition to fundamental parallel computing resear ....Coarse Grained Parallel Algorithms. Various fields of research face barriers created by problems that are computationally hard and/or require processing of large amounts of data. For example, some computational biochemistry methods on protein or gene sequences can not be scaled up to data sets required for human health research because of performance problems. Parallel computing enables new research by increasing the size of solvable problems. In addition to fundamental parallel computing research, this project studies parallel algorithms for structure-based drug design and protein-protein interaction prediction that will enable new biochemistry research, as well as parallel algorithms for data cubes that will help enable the next generation of very large data warehouses.Read moreRead less
Towards automated and intelligent processing of web-based information. The successful outcome of this project will enhance Australia's research reputation in an important, practical area of ICT, will contribute to emerging Web standards, will produce frontier technology that will eventually be of benefit to Australian industry, and will train several postgraduate students.
Rule-based reasoning systems for complex and dynamic ontologies. The successful outcome of this project will enhance Australia's research reputation in an important, practical area of ICT, will contribute to emerging Web technologies that will eventually be of benefit to Australian industry, and will train several postgraduate students.