Discovery Early Career Researcher Award - Grant ID: DE130100614
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Novel statistical algorithms and methods to quantify and partition pleiotropy between complex traits in populations. A fundamental question in biology is how common genetic effects are shared between traits or groups. For example, is cognition or human behaviour genetically identical across genders or across human population groups? This project will address these questions using multiple independent genome-wide association studies.
Enabling Molecular Plant Breeding for Drought Adaptation Using Genome-to-Phenome Modelling Technologies. Effective molecular plant breeding for improved water productivity of sorghum would generate significant economic and social benefits for rural communities in NE Australia. There is a significant opportunity to expand the sorghum industry in the region. Despite the global financial crisis, global demand for meat continues to increase, generating strong demand from intensive livestock industri ....Enabling Molecular Plant Breeding for Drought Adaptation Using Genome-to-Phenome Modelling Technologies. Effective molecular plant breeding for improved water productivity of sorghum would generate significant economic and social benefits for rural communities in NE Australia. There is a significant opportunity to expand the sorghum industry in the region. Despite the global financial crisis, global demand for meat continues to increase, generating strong demand from intensive livestock industries for feed grain. Price is projected to return to high levels given continuing use of major feed grains for biofuel. A 10% increase in sorghum production would add net value of $48M annually, much via employment. The scientific content of this project positions Australia at the leading edge globally in this emerging research field. Read moreRead less
Genome-wide Association Studies Of Biomedical Traits And Endophenotypes For Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$295,804.00
Summary
The burden of common complex diseases, such as cardiovascular disease is substantial to the health care system. These diseases are caused by genes and environments as well as their interactions. The proposed project will identify genes affecting the susceptibility of individuals to complex diseases. Discovery of such genes will be important for their diagnosis, prevention and treatment and may serve as an important resource for future personalized medicine.
Human interaction with context-aware computing systems. Context-aware systems can provide seamless support of IT applications in a variety of technologies and therefore can improve: (i) work performance and adoption of IT in many industries; and (ii) the quality of life through better support for health services, education, and everyday tasks. Currently proposed solutions for context-aware systems fail to deliver systems which are usable for non-IT professionals. The proposed project will show h ....Human interaction with context-aware computing systems. Context-aware systems can provide seamless support of IT applications in a variety of technologies and therefore can improve: (i) work performance and adoption of IT in many industries; and (ii) the quality of life through better support for health services, education, and everyday tasks. Currently proposed solutions for context-aware systems fail to deliver systems which are usable for non-IT professionals. The proposed project will show how to design context-aware systems that are usable and whose autonomic decisions can be trusted. Additional benefits include increased scientific competitiveness of Australia, strengthened collaboration with international research institutions, and high quality graduates (PhDs, Masters, Honours).Read moreRead less
Diagnosis of Reference Flow Control Alerts for the Identification of Malicious Event Sequences (DiagRF). There are a reported two billion computer attacks worldwide per year. Many of these attacks require a skilled human to decipher them and to develop the "signatures" by which they can be detected. The main outcome of this project will be fundamental knowledge regarding how information flows can be tracked and then forensically analysed in a distributed computer system or network in order to ....Diagnosis of Reference Flow Control Alerts for the Identification of Malicious Event Sequences (DiagRF). There are a reported two billion computer attacks worldwide per year. Many of these attacks require a skilled human to decipher them and to develop the "signatures" by which they can be detected. The main outcome of this project will be fundamental knowledge regarding how information flows can be tracked and then forensically analysed in a distributed computer system or network in order to enable the automatic characterization of certain classes of attacks. This new approach will enable the automatic development of attack signatures and thus the detection of such attacks. The project will lead to the development of a prototype which implements the automatic analysis and characterization of such attacks to provide proof of concept.Read moreRead less
Improving Global Tuberculosis Control With The AuTuMN Platform
Funder
National Health and Medical Research Council
Funding Amount
$655,059.00
Summary
Tuberculosis (TB) is the world’s leading infectious killer, with the failure of global control responsible for the vast majority of Australia’s cases. Using our robustly developed software platform, we have performed several country-level studies to predict the future burden of disease and compare the impact of alternative responses to controlling the epidemic. In this project, we will extend our platform to perform simulations at the global level and answer key questions in TB control.
Reducing the risks associated with developing large-scale, critical software-integrated systems. Industry, government and defence increasingly rely on large-scale, critical software-integrated systems. The scale and complexity of these systems means current methods of analysing, designing and assuring their dependability are struggling to provide the constructive support and assurance that is demanded. Consequently, there are significant risks of cost and schedule overruns and of system problems ....Reducing the risks associated with developing large-scale, critical software-integrated systems. Industry, government and defence increasingly rely on large-scale, critical software-integrated systems. The scale and complexity of these systems means current methods of analysing, designing and assuring their dependability are struggling to provide the constructive support and assurance that is demanded. Consequently, there are significant risks of cost and schedule overruns and of system problems and failures. This project builds on results from our current collaboration - a new method for modelling, analysis and defect detection for the requirements of large-scale systems. We will develop and scale-up to industry strength, simpler, more powerful, strategies for analysing, designing and providing the high level of assurance required.Read moreRead less
An Empirically Derived Experimentally Validated Framework for Interactions in Information Environments. This project will investigate and design ways of interacting with the information infrastructure that maintain natural social interactions, take advantage of physical space and utilise our extensive human abilities to recognise and manipulate physical objects.
Expected outcomes include:
? a theoretical framework that describes the range of possible interactions that mediate information b ....An Empirically Derived Experimentally Validated Framework for Interactions in Information Environments. This project will investigate and design ways of interacting with the information infrastructure that maintain natural social interactions, take advantage of physical space and utilise our extensive human abilities to recognise and manipulate physical objects.
Expected outcomes include:
? a theoretical framework that describes the range of possible interactions that mediate information between the physical and virtual worlds.
? a prototype instrumented information environment that demonstrates and validates naturalistic information transactions identified in the framework.
This research is highly innovative in its field. It will use an iterative cycle of video observation, interaction analysis, user-centred device design, deployment and evaluation.
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Defending AI based FinTech Systems against Model Extraction Attacks. This project aims to develop new methods for defending artificial intelligence (AI) based FinTech systems from highly potent and insidious model extraction attacks whereby an adversary can steal the AI model from the system to cause intellectual property (IP) violation, business advantage disruption, and financial loss. This can be achieved by examining various attack models, creating active and utility-preserving defences, and ....Defending AI based FinTech Systems against Model Extraction Attacks. This project aims to develop new methods for defending artificial intelligence (AI) based FinTech systems from highly potent and insidious model extraction attacks whereby an adversary can steal the AI model from the system to cause intellectual property (IP) violation, business advantage disruption, and financial loss. This can be achieved by examining various attack models, creating active and utility-preserving defences, and inventing non-removable watermarks on AI models. The outcomes are new tools for securing AI-based FinTech systems before deployment and tools for IP violation forensics post-deployment. Such capabilities are beneficial by improving the security and safety of FinTech systems and other nationally critical AI systems.Read moreRead less
Investigation of a Dynamic Collaborative Framework for Multi-Modal Devices. Modern business and society increasingly call for agility through the rapid formation of groups and collaboration of individuals. Mobile computing devices have the potential to enable this collaboration. However this is currently unrealised; software is not keeping up with hardware. This project aims to investigate techniques and software tools to provide an adaptive framework for multimedia-rich applications, which seam ....Investigation of a Dynamic Collaborative Framework for Multi-Modal Devices. Modern business and society increasingly call for agility through the rapid formation of groups and collaboration of individuals. Mobile computing devices have the potential to enable this collaboration. However this is currently unrealised; software is not keeping up with hardware. This project aims to investigate techniques and software tools to provide an adaptive framework for multimedia-rich applications, which seamlessly support collaboration through multi-modal communications between heterogenous mobile devices. This combination of multimedia, smart devices and advanced communications has the potential to revolutionise many key industries by making information available and manipulable in new and better ways.Read moreRead less