Shannon Entropy Mapping - AF Ablation From First Principles
Funder
National Health and Medical Research Council
Funding Amount
$439,589.00
Summary
Atrial fibrillation (AF) is the most common heart rhythm disorder in humans, and a rapidly growing epidemic in Australia. AF occurs because electrical circuits called rotors take over the top chambers of the heart. Until now, ablation procedures to target AF have not been able to specifically target rotors, which has meant operations are often long and arduous. This project uses new mathematical techniques we have developed to localise rotors driving AF, aiming to develop a faster safer and more ....Atrial fibrillation (AF) is the most common heart rhythm disorder in humans, and a rapidly growing epidemic in Australia. AF occurs because electrical circuits called rotors take over the top chambers of the heart. Until now, ablation procedures to target AF have not been able to specifically target rotors, which has meant operations are often long and arduous. This project uses new mathematical techniques we have developed to localise rotors driving AF, aiming to develop a faster safer and more effective AF ablation.Read moreRead less
Identification Of Parkinson's Disease Genes In Queensland Families Showing Patterns Of Mendelian Inheritance.
Funder
National Health and Medical Research Council
Funding Amount
$466,759.00
Summary
In rare cases, Parkinson's disease can be inherited through the generations of a family and it is possible to identify genetic changes that lead to this type of disease. This project aims to use new genetic sequencing technologies in several Australian families with inherited PD to find new genes that cause disease. This research will not only help these families but will teach us more about the reasons brain cells degenerate in this condition and other similar age-related brain diseases.
Expanding The Power Of Genetic Analysis Of Complex Traits In Multiply Phenotyped Twin Sibships
Funder
National Health and Medical Research Council
Funding Amount
$541,556.00
Summary
Our aim is to identify genes influencing common diseases including melanoma, asthma and cardiovascular disease. We measure adolescent twins for moliness, skin, hair and eye colour and a variety of blood traits. We have already found new genes for mole count, eye colour, skin damage, and several different blood cell types. For each of these disease traits there are many more genes to be found and these will inform new treatments. We plan to genotype 600 new families (2000 individuals) to help ach ....Our aim is to identify genes influencing common diseases including melanoma, asthma and cardiovascular disease. We measure adolescent twins for moliness, skin, hair and eye colour and a variety of blood traits. We have already found new genes for mole count, eye colour, skin damage, and several different blood cell types. For each of these disease traits there are many more genes to be found and these will inform new treatments. We plan to genotype 600 new families (2000 individuals) to help achieve this.Read moreRead less
We have previously made the most widely used animal brain atlas in the world. This atlas based on stained histological sections of the rat brain. In recent years, advances in MRI have made it possible to generate images of the rat brain at very high resolution. We have obtained a very high quality MRI image set from colleagues in Duke University in the USA, and we have begun to map these images in great detail, using our histological atlas as a guide.
Genetic And Environmental Determinants Of Brain Networks In Ageing
Funder
National Health and Medical Research Council
Summary
Is brain ageing genetically or environmentally determined, or an interaction of both? We will explore the influence of genes and the environment on brain connectivity during ageing by studying how the brain network relates to cognitive functions.
Genetics Of Complex Traits In Multiply Phenotyped Twin Sibships: The Brisbane Longitudinal Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$1,019,887.00
Summary
Our aim is to identify genes influencing common diseases including melanoma, asthma and cardiovascular disease. We measure adolescent twins for moliness, skin, hair and eye colour and a variety of blood traits. We have already found new genes for mole count, eye colour, skin damage, and several different blood cell types. For each of these disease traits there are many more genes to be found and these will inform new treatments. We plan to keep expanding our sample size achieve this.
Caress The Detail: A Comprehensive MRI Atlas Of The In Vivo Human Brain
Funder
National Health and Medical Research Council
Funding Amount
$461,978.00
Summary
This project will construct a detailed MRI atlas of the living human brain. The atlas will be online and compatible with tablet computers to provide a convenient, powerful reference tool for researchers and clinicians. It is a collaboration between George Paxinos, a leader in brain cartography, and Mark Schira, an emerging scientist in MRI technology. They will use high resolution in vivo MR images obtained at the University of Queensland Centre for Advanced Imaging.
Unravelling The Genetic Causes Of Bipolar Disorder: Lessons From Rare But Highly Penetrant Variants In Very Heritable Forms Of Illness
Funder
National Health and Medical Research Council
Funding Amount
$705,834.00
Summary
Bipolar disorder is a severe mood disorder affecting over 350,000 Australians, for which the causes remain largely unknown. This project will apply a powerful new technology, exome sequencing, to rare families with highly heritable forms of bipolar disorder to identify specific genetic factors which increase disease risk. A greater understanding of the genetic causes of this illness may eventually lead to improvements in diagnosis, treatment and quality of life of people suffering with this debi ....Bipolar disorder is a severe mood disorder affecting over 350,000 Australians, for which the causes remain largely unknown. This project will apply a powerful new technology, exome sequencing, to rare families with highly heritable forms of bipolar disorder to identify specific genetic factors which increase disease risk. A greater understanding of the genetic causes of this illness may eventually lead to improvements in diagnosis, treatment and quality of life of people suffering with this debilitating mental illness.Read moreRead less
Identification Of Novel Common Genetic Risk Factors For Endometriosis
Funder
National Health and Medical Research Council
Funding Amount
$593,783.00
Summary
Multiple genetic factors underlie susceptibility to endometriosis—a common gynaecological disease associated with severe pelvic pain and sub-fertility. Through the identification of novel genetic risk factors and pathway-based analyses, this project will increase our understanding of the underlying genetic architecture and complex molecular pathways of endometriosis and lead to the development of diagnostic tests and rational treatment strategies.
CAGE: Consortium For The Architecture Of Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$501,080.00
Summary
This research project is about understanding why some people are most susceptible to disease than others, by identifying genetic factors that influence the expression of genes that are important in disease. We will work with leaders in the field in Europe and the USA in an international research consortium to find genetic variants with an effect on gene expression and to link those genetic factors to disease. The project will provide new understanding about the biological basis of common disease ....This research project is about understanding why some people are most susceptible to disease than others, by identifying genetic factors that influence the expression of genes that are important in disease. We will work with leaders in the field in Europe and the USA in an international research consortium to find genetic variants with an effect on gene expression and to link those genetic factors to disease. The project will provide new understanding about the biological basis of common diseases.Read moreRead less