Genetic variation of transcriptional control. Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction wi ....Genetic variation of transcriptional control. Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction with microarray techniques to analyse expression of thousands of genes simultaneously. These studies will be extended to humans and be significant to wide areas of biological and commercial activity.Read moreRead less
Target detection in visual clutter. The interdisciplinary nature of the project will offer a stimulating environment for training a postdoctoral worker in the hot topic of computational neuroscience. While computationally expensive solutions to moving target detection in clutter have been implemented using conventional engineering, this project will offer insight into the efficiency of the biological brain (with benefit of millions of years of evolution towards compact, economical and optimal so ....Target detection in visual clutter. The interdisciplinary nature of the project will offer a stimulating environment for training a postdoctoral worker in the hot topic of computational neuroscience. While computationally expensive solutions to moving target detection in clutter have been implemented using conventional engineering, this project will offer insight into the efficiency of the biological brain (with benefit of millions of years of evolution towards compact, economical and optimal solutions). The results will assist development of efficient artificial intelligence. It will also assist our ongoing collaborations with defence partners to develop and apply algorithms in artificial vision systems. Read moreRead less
Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed b ....Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed by academics. We hypothesise that current 3D relational visualization methods fail because they do not pay attention to the human perception of topology. In this project we will leverage mathematical topology to construct new methods for the 3D visualization of relational data.
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New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive f ....New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive feedback loop in the course of research into both topics.Read moreRead less
A genetic analysis of the role of an atypical hexokinase in gene regulation. This project addresses a question which is relevant to all living things-how do changes in the environment of a cell bring about a change in gene expression? The aim of this project is to investigate the role of hexokinases in gene regulation by studying the Aspergillus nidulans xprF gene, which encodes an an unusual hexokinase. Hexokinases are thought to be the glucose sensors in plants, animals and fungi, and play a ....A genetic analysis of the role of an atypical hexokinase in gene regulation. This project addresses a question which is relevant to all living things-how do changes in the environment of a cell bring about a change in gene expression? The aim of this project is to investigate the role of hexokinases in gene regulation by studying the Aspergillus nidulans xprF gene, which encodes an an unusual hexokinase. Hexokinases are thought to be the glucose sensors in plants, animals and fungi, and play a role in the development of diabetes in humans. In plants, sugars affect many processes including growth, flowering, photosynthesis, nitrogen metabolism, starch synthesis, pigmentation and response to pathogens.Read moreRead less
Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is ....Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is applicable in a range of areas, with applications in miniature unmanned vehicles and collision avoidance detectors in defence and civilian roles. Our project could also assist in the development of artificial intelligence and as a basis for designing implantable artificial eyes.Read moreRead less
Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identi ....Statistical Methods for Discovering Ribonucleic acids (RNAs) contributing to human diseases and phenotypes. Identifying the causative genetic factors involved in quantitative phenotypes and diseases is a major goal of biology in the 21st century and beyond. A crucial step towards this goal is identifying and classifying the functional non-protein-coding Ribonucleic acids (RNAs) encoded in the human genome. This project will make major contributions to international efforts in this area by identifying RNA molecules that contribute to quantitative phenotypes including susceptibility to disease. As such, it will directly benefit fundamental science via the discovery and classification of new molecules. Indirectly, it will lead to breakthroughs in biology, and consequently to major medical and pharmaceutical advances in the diagnosis and treatment of genetic disease.Read moreRead less
Statistical and Mathematical Analyses of Sequence and Array Data. Development of mathematical and statistical methods and tools in bioinformation science will ensure that Australia is at the cutting-edge of modern biology. This will enhance Australia's reputation for dealing with the exponentially growing body of genomic data emerging from life sciences laboratories throughout the world. The proposed project has a broad range of potential applications in biotechnology, particularly in the medic ....Statistical and Mathematical Analyses of Sequence and Array Data. Development of mathematical and statistical methods and tools in bioinformation science will ensure that Australia is at the cutting-edge of modern biology. This will enhance Australia's reputation for dealing with the exponentially growing body of genomic data emerging from life sciences laboratories throughout the world. The proposed project has a broad range of potential applications in biotechnology, particularly in the medical and agricultural industries. Examples include improvements to livestock, in plant breeding such as drought resistance, and better genetic disease diagnosis, including earlier cancer diagnosis, and personalised treatment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775587
Funder
Australian Research Council
Funding Amount
$532,000.00
Summary
Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions ....Correlating Genomics and Proteomics for Systems Biology: integrating the '-omics'. Acquisition of the infrastructure requested will maintain and extend the expertise developed by researchers in NSW and will allow retention and attraction of leading researchers who can contribute to understanding how genes and proteins interact in the development of the organism - the central focus of systems biology. The enhancement of the facility will allow a better understanding of biomolecular interactions in health and disease, providing both community and national benefits. The focus of this LIEF application is to provide infrastructure platforms for the study of the systems biology of organisms and additional capacity by the facility for the expected increased demand for this technology in this new area. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882382
Funder
Australian Research Council
Funding Amount
$245,000.00
Summary
Biophysical Characterisation Facility. The protein analysis facility will have substantial benefits for basic science and biotechnology. It will create capacity for South Australian researchers to study proteins at the biophysical level. The facility will support research projects within the designated national research priority areas of 'Frontier technologies for building and transforming Australian industries' and 'Promoting and maintaining good health