Finding and exploiting interesting paths in multidimensional information spaces. This project will invent a new approach for searching within a large complex information space, finding interesting paths between points within the space, visualising the results, and supporting rich, human-centric user interaction with queries and results. This project will embody these techniques in a novel, internet-scale framework to support rapid development of large path search and visualisation applications. ....Finding and exploiting interesting paths in multidimensional information spaces. This project will invent a new approach for searching within a large complex information space, finding interesting paths between points within the space, visualising the results, and supporting rich, human-centric user interaction with queries and results. This project will embody these techniques in a novel, internet-scale framework to support rapid development of large path search and visualisation applications. Evaluation will be via development of several exemplar applications. The techniques and framework will be applicable to a broad range of economically important problems in areas as diverse as health, travel, scientific publication search, product marketing and software engineering.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775582
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
Data Grid -- Access Layer. Vast increases in computing power and the arrival of new scientific instruments are contributing to the so-called data deluge of the 21st century. Accessing and archiving these data is essential to research. While the underlying computing and network requirements are well resourced, data access has been relatively neglected in Australia. A continuing problem in Australian research communities is the absence of coordinated access to digital storage resources. In many ca ....Data Grid -- Access Layer. Vast increases in computing power and the arrival of new scientific instruments are contributing to the so-called data deluge of the 21st century. Accessing and archiving these data is essential to research. While the underlying computing and network requirements are well resourced, data access has been relatively neglected in Australia. A continuing problem in Australian research communities is the absence of coordinated access to digital storage resources. In many cases computational and experimental data are stored on ad-hoc resources, such as local university servers, PC disc drives, and are not generally accessible. The central goal of this proposal is to provide access to an integrated scientific data storage capacity for Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668445
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Data Grid Storage Infrastructure for e-Research. Vast increases in computing power and the arrival of new scientific instruments are contributing to the so-called data deluge of the 21st century. Archiving these data is essential to research. While the underlying computing and network requirements are well resourced, data storage capacity has been relatively neglected in Australia. A continuing problem in Australian research communities is the absence of coordinated digital storage resources. In ....Data Grid Storage Infrastructure for e-Research. Vast increases in computing power and the arrival of new scientific instruments are contributing to the so-called data deluge of the 21st century. Archiving these data is essential to research. While the underlying computing and network requirements are well resourced, data storage capacity has been relatively neglected in Australia. A continuing problem in Australian research communities is the absence of coordinated digital storage resources. In many cases computational and experimental data are stored on ad-hoc resources, such as local university servers, PC disc drives, CDs, or DVDs, and are not generally accessible. The central goal of this proposal is to provide a long-term, integrated scientific data storage capacity for Australia. Read moreRead less
Semantic Vectorisation: From Bitmaps to Intelligent Representations. The objective of this innovative project is to provide a solution to the open question of representing natural images by semantically rich vector graphics. The challenges are to identify key visual and temporal elements for images and videos, and efficiently decompose the visual data into semantic vector representations that are faithful to original data, compact and editable. The project aims to investigate new bitmap-to-vecto ....Semantic Vectorisation: From Bitmaps to Intelligent Representations. The objective of this innovative project is to provide a solution to the open question of representing natural images by semantically rich vector graphics. The challenges are to identify key visual and temporal elements for images and videos, and efficiently decompose the visual data into semantic vector representations that are faithful to original data, compact and editable. The project aims to investigate new bitmap-to-vector conversion methods. It is expected to develop a framework where semantic labels and hyperlinks can be embedded in visual data automatically. It hopes to pioneer the creation of a web of images where the links are on image/video regions. New image simplification, stylisation, and non-photorealistic rendering methods are expected to be provided.Read moreRead less
Curating Photography in the Age of Photo Sharing. This project aims to develop new curatorial models to enable Australian art galleries to respond effectively to changes in the medium of photography wrought by digital technologies. By conducting the first comprehensive analysis of nearly five decades of Australian photography curating and comparing it to curatorial approaches in related institutions locally and internationally, the project seeks to: identify the crucial role of photography exhib ....Curating Photography in the Age of Photo Sharing. This project aims to develop new curatorial models to enable Australian art galleries to respond effectively to changes in the medium of photography wrought by digital technologies. By conducting the first comprehensive analysis of nearly five decades of Australian photography curating and comparing it to curatorial approaches in related institutions locally and internationally, the project seeks to: identify the crucial role of photography exhibitions in the shaping of Australian visual culture; and develop opportunities for curators to better engage with the current proliferation of images, including new forms and practices of photography enabled by the Internet.Read moreRead less
Reducing The Greatest Uncertainty In Radiotherapy.
Funder
National Health and Medical Research Council
Funding Amount
$594,197.00
Summary
The weakest link in radiotherapy is defining treatment volumes (contouring). Lack of accuracy and consistency in clinical trial contouring has been shown to result in reduced patient outcomes. Manual review of contouring is resource intensive, expensive and for advanced treatments unachievable in a timely fashion. We will assess an automated approach to contouring assessment using 4 clinical trial datasets, changing practice for future studies and enabling consistent assessment in the clinic.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.