Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ....ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ultimately harness the Grid, enabling linkage into other national and international Grid systems. Encompassing physics, computer science, applied mathematics, chemistry and biochemistry, and catalysing interaction across these disciplines, the MMSN will impact all five National Research Priority 3 goals.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH120100021
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainabil ....Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainability and innovation in food value chains.Read moreRead less
Improving the diagnosticity of eyewitness memory choices. Eyewitness identification error is common and costly. This project aims to improve the quality of information provided by eyewitnesses, and the ability of police officers and triers of fact (e.g., juries, judges) to evaluate this information. Laboratory investigations will determine how best to test memory and confidence to achieve this aim. A new class of cognitive models will provide a unified account of response accuracy, response time ....Improving the diagnosticity of eyewitness memory choices. Eyewitness identification error is common and costly. This project aims to improve the quality of information provided by eyewitnesses, and the ability of police officers and triers of fact (e.g., juries, judges) to evaluate this information. Laboratory investigations will determine how best to test memory and confidence to achieve this aim. A new class of cognitive models will provide a unified account of response accuracy, response time, and confidence, suitable for application to computerized testing scenarios. The models and testing methods validated in the laboratory will be refined for application in eyewitness memory settings, facilitating better evaluation of identification evidence, and potentially reducing wrongful convictions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100211
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
The Big Australian Speech Corpus: An audio-visual speech corpus of Australian English. Contemporary speech science and technology are driven by the availability of large speech corpora. While audio databases exist for languages spoken in America, Europe and Japan, there is currently no large auditory-visual database of spoken language, and certainly not one for Australian English. Here we will establish the Big Australian Speech Corpus, which will support a speech science research and developmen ....The Big Australian Speech Corpus: An audio-visual speech corpus of Australian English. Contemporary speech science and technology are driven by the availability of large speech corpora. While audio databases exist for languages spoken in America, Europe and Japan, there is currently no large auditory-visual database of spoken language, and certainly not one for Australian English. Here we will establish the Big Australian Speech Corpus, which will support a speech science research and development using Australian English and facilitate the development of Australian speech technology applications from automatic speech recognition and text-to-speech synthesis used in taxi and other ordering services, to hearing prostheses and talking head aids for learning-impaired children, and a range of security and forensic applications.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH180100002
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. Thes ....ARC Research Hub for Driving Farming Productivity and Disease Prevention. The ARC Research Hub for Driving Farming Productivity and Disease Prevention aims to increase farm production and disease prevention through advancing and transferring new artificial intelligence technologies into industrial deployment. The Hub will combine machine vision, machine learning, software quality control, engineering, biology, and farming industries to develop technologies to build more intelligent systems. These dynamic systems will help determine what goal to achieve and the most efficient plan to achieve it. This Hub is expected to contribute to higher farming efficiency, lower production costs and fewer disease risks, giving the Australian industry new business opportunities and an international competitive advantage.Read moreRead less
Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed g ....Global Citizen Deliberation: Analysing a Deliberative Documentary. The project will enact and film the world’s first truly global citizens’ deliberation, a global citizens’ assembly (GCA) on genome editing, and proceed to analyse the impact of the ‘deliberative documentary’ film on public understanding of complex, fast-evolving science and technology. It will investigate the cross-cultural capacity of citizens to deliberate complex value-laden issues, and so ascertain prospects for an informed global public response to challenges posed by genome editing. Research will test the effects of the deliberative documentary on viewers, examining benefits of communicating complex issues via the work of the GCA. Other benefits include improving public trust in governance and advancing the Australian film industry.
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