Systems For Control And Tracking Of Infectious Diseases In A Globalised World
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
Infectious disease informatics now at the forefront of translational research due to the recent rapid growth of microbial genomics, significant advances in molecular diagnostics and increasing demands for real-time biosurveillance. This program of multidisciplinary research will redefine existing paradigms, develop novel systems for surveillance of biothreats and offer new insights into transmission dynamics of pathogens with epidemic potential in Australia.
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Methodological Research In Meta-analysis And Evidence Synthesis: An Evidence-based Methods Approach
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Systematic reviews synthesize available research to determine whether policy, health service delivery, public health, and clinical interventions are effective. Statistical methods underpin the validity of the findings in systematic reviews. This research will evaluate and develop statistical methods for systematic reviews with the aim of improving the quality of reviews and ensuring healthcare decisions are based on reliable research syntheses.
Therapeutics For Repair And Regeneration Of The Cornea
Funder
National Health and Medical Research Council
Funding Amount
$166,087.00
Summary
Corneal disease is the commonest cause of irreversible blindness and of the 50 million people world-wide who are bilaterally blind, 10 million are blind from corneal involvement. This proposal will address corneal disease by 1. innovative translational research for corneal repair and regeneration; 2. developing evidence-based management guidelines for corneal disease, and 3. by optimising health service delivery.
Preventing Suicide In Young People: A Public Health Approach
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Suicide is the leading cause of death in young Australians. This fellowship aims to lower risk for suicide by testing: a) whether improving the connectedness of adolescents in schools can improve help-seeking, b) whether parents can learn to recognise risk in their children, and c) whether school screening is an appropriate and effective strategy to reduce risk. Practical outcomes will be new programs for youth, new strategies for parents and a better integrated approach for Australian schools.
International Strategies To Reduce Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Effective, sustainable and scalable strategies to reduce salt are needed so countries can achieve the global target to reduce salt by 30% by 2025. This research program will support the optimal development of such strategies through trials and intervention research projects, supplemented through a series of systematic reviews and feasibility and cost-effectiveness assessments. The main outcome will be new evidence on the effectiveness of different interventions to support translation globally.
Development Of Endogenous Granulocyte Colony Stimulating Factor (G-CSF) Antagonism As A New Therapeutic Approach To Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$401,561.00
Summary
Neutrophils play a pivotal role in inflammatory diseases including rheumatoid arthritis (RA). G-CSF is a growth factor that is important to neutrophil survival and function. We have shown that in the absence of G-CSF the incidence and severity of experimental autoimmune arthritis are reduced. We will investigate the mechanisms by which this occurs as well as studying the effects of G-CSF blockade on function and survival of human neutrophils from healthy donors and RA patients.