Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optim ....Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optimisation of Complex Systems.Read moreRead less
Derivative free algorithms for large scale nonsmooth and global optimization and their applications. The outcomes expected from this research fall broadly into two categories: 1) the development of a new class of effective readily implementable derivative free techniques for large scale non-smooth and global optimisation and 2) the development of new algorithms based on derivative free optimization techniques for solving data mining, resource allocation problems and some problems in bioinformati ....Derivative free algorithms for large scale nonsmooth and global optimization and their applications. The outcomes expected from this research fall broadly into two categories: 1) the development of a new class of effective readily implementable derivative free techniques for large scale non-smooth and global optimisation and 2) the development of new algorithms based on derivative free optimization techniques for solving data mining, resource allocation problems and some problems in bioinformatics. In particular, the application of these techniques to molecular biology and cluster analysis will be very important for the development of competitive technologies for Australia.
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Approximate bundle methods in nonsmooth optimisation and their applications in some complex systems. Non-smooth and non-convex optimisation has many applications in industry and science. One of the powerful methods in non-smooth optimisation is a bundle method. This project will develop new versions of the bundle method by using continuous approximations to the sub-differential and extend this method for solving non-convex (smooth and non-smooth) optimisation problems by using max-min of linear ....Approximate bundle methods in nonsmooth optimisation and their applications in some complex systems. Non-smooth and non-convex optimisation has many applications in industry and science. One of the powerful methods in non-smooth optimisation is a bundle method. This project will develop new versions of the bundle method by using continuous approximations to the sub-differential and extend this method for solving non-convex (smooth and non-smooth) optimisation problems by using max-min of linear functions for the approximation of the functions involved. The outcome will be a new class of effective readily implementable algorithms for the minimization of non-smooth and non-convex functions, whose usefulness will be demonstrated by applications in cluster analysis, biochemistry and robotics.
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Filled function methods for global optimization and their applications. Many real problems in science, commerce and industry are restricted in the way that they are modelled and solved by the known inability to deal with global optimization problems. The development of computational efficient global optimization methods in this project will allow new more complete approaches to these problems, especially in new areas of bio-informatics, data mining, economic modelling, supply chain management, ....Filled function methods for global optimization and their applications. Many real problems in science, commerce and industry are restricted in the way that they are modelled and solved by the known inability to deal with global optimization problems. The development of computational efficient global optimization methods in this project will allow new more complete approaches to these problems, especially in new areas of bio-informatics, data mining, economic modelling, supply chain management, air traffic management, biochemical engineering and automotive industry, consequently helping Australia advance in these various areas. It will also enhance the understanding of global optimization from both theoretical and numerical viewpoints, particularly boosting optimization research in Australia.Read moreRead less
Information Geometry and Compressive Sensing for Radar and Communications. Australia's vast distances, thin population and extensive sea approaches force us to place heavy reliance on telecommunications and the remote sensing that radar and other modalities can provide. This project will enchance capabilities in sensing to provide more reliable, robust and cost effective communications and surveillance over a wide area.
GEOMETRIC NUMERICAL INTEGRATION. Many scientific phenomena in physics, astronomy, and chemistry, are modelled by ordinary differential equations (ODEs). Often these equations have no solution in closed form, and one relies on numerical integration. Traditionally this is done using Runge-Kutta methods or linear multistep methods. In the last decade, however, we (and others) have discovered novel classes of so-called "geometric" numerical integration methods that preserve qualititative featur ....GEOMETRIC NUMERICAL INTEGRATION. Many scientific phenomena in physics, astronomy, and chemistry, are modelled by ordinary differential equations (ODEs). Often these equations have no solution in closed form, and one relies on numerical integration. Traditionally this is done using Runge-Kutta methods or linear multistep methods. In the last decade, however, we (and others) have discovered novel classes of so-called "geometric" numerical integration methods that preserve qualititative features of certain ODE's exactly (in contrast to traditional methods), leading to crucial stability improvements. Extending concepts from dynamical systems theory and traditional numerical ODEs, this project will improve, extend and systematize this new field of geometric integration.Read moreRead less
Geometric Integration. This project gives an important boost to Australia's strength in the niche area of geometric numerical integration,in the face of strong international competition. It gathers 7 world experts from 5 countries to create new computer programs to improve calculations in dynamics, with applications ranging from astronomy, physics, chemistry, biology, and meteorology to finance. It strengthens Australia's links with the mathematical software industry, and will lead to world-clas ....Geometric Integration. This project gives an important boost to Australia's strength in the niche area of geometric numerical integration,in the face of strong international competition. It gathers 7 world experts from 5 countries to create new computer programs to improve calculations in dynamics, with applications ranging from astronomy, physics, chemistry, biology, and meteorology to finance. It strengthens Australia's links with the mathematical software industry, and will lead to world-class graduates and research training.Read moreRead less
Geometric numerical integration of differential equations. Differential equations (DEs) play a central role in modelling scientific phenomena in physics, biology, chemistry, astronomy, meteorology, and geoscience. We have developed new ways of solving DEs, using geometric integration, which have significant advantages over traditional methods because of the crucial nonlinear stability they provide.
This project, combining 7 world experts from 6 countries and 1 early career researcher, will pl ....Geometric numerical integration of differential equations. Differential equations (DEs) play a central role in modelling scientific phenomena in physics, biology, chemistry, astronomy, meteorology, and geoscience. We have developed new ways of solving DEs, using geometric integration, which have significant advantages over traditional methods because of the crucial nonlinear stability they provide.
This project, combining 7 world experts from 6 countries and 1 early career researcher, will place Australia at the forefront of this intensive international activity.
It will significantly strengthen Australia's links with the mathematical software industry (e.g. Wolfram Research, Inc), and will lead to world class graduates and research training.
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Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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The estimation of genotype-phenotype relationships from family data and of animal abundance from capture-recapture data with frequent capture occasions: A semiparametric approach. Semiparametric statistical methods allow researchers to only model those features of their data that are of interest, but still allow standard statistical inferences to be made about these features. The aim here is to develop non standard applications of semiparametric statistical methods in the estimation of genotype ....The estimation of genotype-phenotype relationships from family data and of animal abundance from capture-recapture data with frequent capture occasions: A semiparametric approach. Semiparametric statistical methods allow researchers to only model those features of their data that are of interest, but still allow standard statistical inferences to be made about these features. The aim here is to develop non standard applications of semiparametric statistical methods in the estimation of genotype-phenotype relationships from family data and the estimation of animal abundance from capture-recapture data. The methods will be applied to real data and their theoretical properties developed. The practical significance of the project is the flexible new statistical methods that will become available to researchers. The theoretical significance will be the insights into semiparametric methods gained by developing these nonstandard applications. The expected outcomes are the new statistical procedures and the resulting theoretical insights into semiparametric statistics.Read moreRead less