Discovery Early Career Researcher Award - Grant ID: DE160100227
Funder
Australian Research Council
Funding Amount
$355,481.00
Summary
Experimentally validated multiphase mathematical models of leg ulcers. The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the forma ....Experimentally validated multiphase mathematical models of leg ulcers. The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the formation and healing of a leg ulcer – biological processes which are currently poorly understood. The mathematical models are expected to provide new insight into the underlying biological mechanisms of leg ulcers and may ultimately improve management of chronic wounds.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries ....Patient-specific Computational Tools for Diagnosing and Treating Gait Disorders in Children with Cerebral Palsy. This proposal addresses one of the most fundamental and difficult questions related to the treatment of children with cerebral palsy: Why do these children walk in a crouched position, with excessively bent hips and knees? High-fidelity, patient-specific computer simulations of walking can help to answer this question and, in so doing, can improve the outcomes of orthopaedic surgeries designed to correct movement abnormalities in these patients. Realistic computer simulations of human movement can play a pivotal role in healthcare through patient rehabilitation; in sports, through the development of personalized training programs for elite athletes; and in entertainment, through the creation of video games and animated films.Read moreRead less
Performance evaluation and characterisation for filtering in multi-object system. The project falls within the National Research Priority of 'Safeguarding Australia' and associated research priority goal of 'Transforming Defence Technology'. The project outcomes will provide cutting edge technology in surveillance, and monitoring of potential threat in our air, sea, and land space. Fast, reliable information enable our personnel to make timely, intelligent judgements, and appropriate responses i ....Performance evaluation and characterisation for filtering in multi-object system. The project falls within the National Research Priority of 'Safeguarding Australia' and associated research priority goal of 'Transforming Defence Technology'. The project outcomes will provide cutting edge technology in surveillance, and monitoring of potential threat in our air, sea, and land space. Fast, reliable information enable our personnel to make timely, intelligent judgements, and appropriate responses in the event of a threat, thereby maintaining Australia's operational advantage. Other application areas that benefits from our research include radar, sonar, guidance, navigation, air traffic control, image processing, oceanography, autonomous vehicles and robotics, remote sensing, and biomedical research.
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Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and bi ....Optimal Control of Multi-Object System. Better understanding of multi-object systems developed from this research, in particular, optimal control algorithms for multi-object systems have several significant socio-economic benefits. Application areas that benefits from our research include aerospace applications such as radar, sonar, guidance, navigation, and air traffic control and non-aerospace areas such as image processing, oceanography autonomous vehicles and robotics, remote sensing, and biomedical research. The sensor network discipline also stand to benefit from the understanding of multi-object system and control framework. Read moreRead less
Advanced control and estimation strategies for electromechanical brake-by-wire systems. The project aims to investigate the application of advanced control and estimation techniques (robust nonlinear and soft-computing approaches) to the problem of maximising the effectiveness of electromechanical brake-by-wire systems in emergency braking manoeuvres. The work will be conducted using state-of-the-art control design and hardware-in-the loop simulation facilities in the Research Centre for Advance ....Advanced control and estimation strategies for electromechanical brake-by-wire systems. The project aims to investigate the application of advanced control and estimation techniques (robust nonlinear and soft-computing approaches) to the problem of maximising the effectiveness of electromechanical brake-by-wire systems in emergency braking manoeuvres. The work will be conducted using state-of-the-art control design and hardware-in-the loop simulation facilities in the Research Centre for Advanced By-Wire Technologies (RABiT), which has been established to accelerate the development and commercialisation of by-wire technology in Australia. Expected outcomes are actuator and road friction control algorithms which have been demonstrated to be robust in the context of real-world actuator and vehicle dynamics.Read moreRead less
Using Mathematics to Maximize the Value of Open-Pit Mines. Mineral resources are one of Australia's greatest assets. Their effective management will bring substantial long-term benefits to the Australian economy. Planning the exploitation of a mineral resource is a highly complex task. Current methods are approximate, and do not fully consider two critical issues: (1) ore mined at different times must be blended to achieve saleable product and (2) resource markets may not evolve as predicted ....Using Mathematics to Maximize the Value of Open-Pit Mines. Mineral resources are one of Australia's greatest assets. Their effective management will bring substantial long-term benefits to the Australian economy. Planning the exploitation of a mineral resource is a highly complex task. Current methods are approximate, and do not fully consider two critical issues: (1) ore mined at different times must be blended to achieve saleable product and (2) resource markets may not evolve as predicted. In this project we shall develop creative mathematical solutions to maximise the expected net present value of mines with far greater accuracy, taking into account blending and the uncertain nature of future demand.Read moreRead less
Modelling large urban transport networks using stochastic cellular automata. Urban traffic congestion is a major social, economic and environmental problem, and to overcome it we need reliable and flexible mathematical models of traffic flow. This project will introduce and study new mathematical traffic models, and use them to study innovative traffic signal systems for our arterial roads, freeways, and tram routes.
Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowle ....Multi-scale modelling of cell migration in developmental biology. Interpretative and predictive tools are needed for the comprehensive understanding of directed cell migration in the medical sciences. Mathematical models and modelling methodologies developed in this project will make a significant contribution to the investigation of cell migration and the testing and generation of hypotheses. Such models are needed to understand observed cellular patterns. This project will contribute to knowledge of normal and abnormal developmental processes, especially in embryonic growth. Understanding these processes should lead to prediction and treatment of congenital disorders and contribute to a healthy start to life.Read moreRead less
Multiscale models in immuno-epidemiology. The spread of a pathogen (for example, a virus or bacteria) through a population is a multi-scale phenomena, influenced by factors acting at both the population and within-host scales. At the population scale, transmission is influenced by how infectious an infected host is. Infectiousness in turn depends on the balance between pathogen replication within the host and immune/drug control mechanisms. This project aims to develop new mathematical framework ....Multiscale models in immuno-epidemiology. The spread of a pathogen (for example, a virus or bacteria) through a population is a multi-scale phenomena, influenced by factors acting at both the population and within-host scales. At the population scale, transmission is influenced by how infectious an infected host is. Infectiousness in turn depends on the balance between pathogen replication within the host and immune/drug control mechanisms. This project aims to develop new mathematical frameworks for simultaneously modelling these two scales. This will provide a platform for the rigorous study of complex biological interactions - such as the emergence and combat of drug-resistance - that shape society's ability to control infectious diseases in human, animal and plant systems.Read moreRead less