Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100110
Funder
Australian Research Council
Funding Amount
$3,021,288.00
Summary
New Approaches to Understand How Form and Function Shape Complex Systems. As biology and medicine transform into quantitative sciences, existing mathematical methods are often inadequate to explain the data they generate. This project aims to unlock the potential of such biomedical data through the development of new mathematical approaches that combine concepts from pure and applied mathematics, statistics and data science, and then to investigate their ability to generate mechanistic insight i ....New Approaches to Understand How Form and Function Shape Complex Systems. As biology and medicine transform into quantitative sciences, existing mathematical methods are often inadequate to explain the data they generate. This project aims to unlock the potential of such biomedical data through the development of new mathematical approaches that combine concepts from pure and applied mathematics, statistics and data science, and then to investigate their ability to generate mechanistic insight into fundamental biomedical processes. In this way, the project expects to affect a paradigm shift in mathematical biology while strengthening Australia’s reputation as a world-leader in mathematical biology. An outcome from this project could be new mathematical models that guide decision making in the clinic.Read moreRead less
Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This resear ....Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This research program will develop the complex signal processing and system methodology needed to create a suitable tool set.Read moreRead less
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less
Modelling and estimation techniques for the transmission and control of Tuberculosis with new and existing vaccines. Most Tuberculosis in Australia is seen in foreign-born people. Australia has an important role in providing leadership in the Asia-Pacific region in Tuberculosis control, which will have flow-on benefits to TB control in this country. Using mathematical models, this project will assess the use of vaccines for Tuberculosis in the developing world. Rising levels of extremely drug r ....Modelling and estimation techniques for the transmission and control of Tuberculosis with new and existing vaccines. Most Tuberculosis in Australia is seen in foreign-born people. Australia has an important role in providing leadership in the Asia-Pacific region in Tuberculosis control, which will have flow-on benefits to TB control in this country. Using mathematical models, this project will assess the use of vaccines for Tuberculosis in the developing world. Rising levels of extremely drug resistant infections make this a timely and important study with significant policy implications, both externally and in the Australian context. Read moreRead less
A Bayesian framework for frequency domain identification. The national and social benefits of the project will be reflected
through the application recognition of the research work in the various industry and research community; and also through our international collaboration. The national and social benefits are also delivered by producing specialized researchers and engineers in systems and control engineering. These people include the research students who will participate in and learn f ....A Bayesian framework for frequency domain identification. The national and social benefits of the project will be reflected
through the application recognition of the research work in the various industry and research community; and also through our international collaboration. The national and social benefits are also delivered by producing specialized researchers and engineers in systems and control engineering. These people include the research students who will participate in and learn from the proposed project.Read moreRead less
Optimal Control of Stochastic Partial Differential Equations. The problem to control a stochastic process so as to minimize a certain cost functional arises in many areas of Applied Sciences, Engineering and Mathematical Finance. An important practical question is to find, for a given cost functional, the optimizing control in a feedback form. We propose new tools to construct such optimal controls for a class of stochastic processes which are solutions to stochastic partial differential equati ....Optimal Control of Stochastic Partial Differential Equations. The problem to control a stochastic process so as to minimize a certain cost functional arises in many areas of Applied Sciences, Engineering and Mathematical Finance. An important practical question is to find, for a given cost functional, the optimizing control in a feedback form. We propose new tools to construct such optimal controls for a class of stochastic processes which are solutions to stochastic partial differential equations. As an outcome of this project we will obtain methods to determine the optimal control policies for a large variety of cost functionals and degenerated stochastic partial differential equations, in particular those arising in modelling of volatility in Finance.Read moreRead less
A probabilistic and geometric understanding of transport and metastability in mathematical geophysical flows. Complicated fluid flow is at the heart of physical oceanography and atmospheric science. This project will develop new mathematical technologies to reveal hidden transport barriers around which complicated fluid flow is organised. This project will lead to more accurate circulation predictions from ocean and atmosphere models.
Discovery and tracking of coherent structures in geophysical flows. Coherent structures in geophysical flows play fundamental roles by organising fluid flow and obstructing transport. For example, ocean eddies strongly influence the transportation of heat, nutrients, phytoplankton, and fish larvae, in both the horizontal and vertical direction. Many coherent structures are very difficult to detect and track by direct measurement (for example satellite observations), and current mathematical tech ....Discovery and tracking of coherent structures in geophysical flows. Coherent structures in geophysical flows play fundamental roles by organising fluid flow and obstructing transport. For example, ocean eddies strongly influence the transportation of heat, nutrients, phytoplankton, and fish larvae, in both the horizontal and vertical direction. Many coherent structures are very difficult to detect and track by direct measurement (for example satellite observations), and current mathematical techniques cannot provide an adequate global description. This project aims to create innovative new mathematical theory and numerical methods to discover and track coherent structures over time frames of physical importance, contributing significantly to our understanding of their role in the oceans' biosphere and climate.Read moreRead less
Innovative mathematics using transfer operators to reveal hidden ordered structures in geophysical flows. Complicated fluid flow is at the heart of physical oceanography and atmospheric science. This research will develop new mathematical technologies to reveal hidden ordered structures around which complicated fluid flow is organised. This new analytical approach will lead to more accurate circulation predictions from ocean and atmosphere models.