A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can ....A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can be used by engineers in Australia and France to simulate transport phenomena in porous media, which have significant environmental impact. The research will lead to publications in scientific journals and communications at national/international conferences. Research training of postdocs and PhD students is another excellent outcome of the project.Read moreRead less
Next-Generation OFDM Communication Systems: Analysis and Design for the Physical Layer. Next-generation orthogonal frequency-division multiplexed (OFDM) systems represent the future of broadband wireless access technology. Such systems are vital to Australia's future infrastructure and growing economy by providing more bandwidth with greater flexibility for new broadband applications. The research outcomes from this project will help enable future OFDM systems, and thus directly benefit Austra ....Next-Generation OFDM Communication Systems: Analysis and Design for the Physical Layer. Next-generation orthogonal frequency-division multiplexed (OFDM) systems represent the future of broadband wireless access technology. Such systems are vital to Australia's future infrastructure and growing economy by providing more bandwidth with greater flexibility for new broadband applications. The research outcomes from this project will help enable future OFDM systems, and thus directly benefit Australia. Development of cutting-edge information technology know-how will enhance Australia's international ICT reputation. Valuable research training of highly-skilled Australian students is another important benefit.Read moreRead less
Venoms To Drugs: Characterizing The Molecular Interactions Between Venom Peptides And Ion Channels With A View To Rational Drug Design
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The conventional approach to drug development is reaching a state of crisis as it is producing fewer new drugs at increasing cost. A promising alternative is to harness the rich and diverse chemistry of venom peptides. This project aims to understand the mechanism by which venom peptides achieve their pharmacological activity. This knowledge is essential for venom-based drug design for treating diseases ranging from nervous systems disorders, stroke, chronic pain and psychiatric illnesses.
Cyclic-nucleotide-dependent Regulation Of Axon Guidance Sensitivity
Funder
National Health and Medical Research Council
Funding Amount
$527,338.00
Summary
Problems in wiring up the brain underlie several nervous system disorders. The goal of this project is to understand better how this wiring normally forms. This will ultimately lead to a better understanding of what can go wrong with brain wiring, and how to fix such problems. It will also lead to a better understanding of how to make axons regenerate after injury.
Biotransport design for engineering microenvironment in scaffolds. Tissue engineering signifies an exciting opportunity to solve shortage of transplantable tissues. This project targets a critical issue in engineering thick tissue and aims to introduce computational structural optimisation to biotransport problems. The optimal scaffold is expected to create a more desirable microenvironment for better tissue growth.
Colorectal cancer is a common malignancy in Australia and the mutation of one gene (Apc) is implicated in >80% of the cases. We aim to understand Apc biochemistry in normal and colon cancer cells by integrating mathematics with our experimental biology program. The main outcomes for this project will be a better understanding of the regulatory systems perturbed in colon cancer. We believe that the insights gained by our research will point the way to more effective treatments of colon cancer.
Perturbation and approximation methods for linear operators with applications to train control, water resource management and evolution of physical systems. Linear equations are used to solve practical problems. In realistic problems the equations and their solutions depend on parameters obtained by measurement of physical quantities and on data derived from observations and experiments. Changes to the values of the key parameters will lead to changes in the solutions. This project will devel ....Perturbation and approximation methods for linear operators with applications to train control, water resource management and evolution of physical systems. Linear equations are used to solve practical problems. In realistic problems the equations and their solutions depend on parameters obtained by measurement of physical quantities and on data derived from observations and experiments. Changes to the values of the key parameters will lead to changes in the solutions. This project will develop methods to better understand the relationships between the key parameters and the solutions and will apply the new insights to practical problems such as the minimization of fuel consumption in trains, optimal resource management in water supply systems and the evolution of physical systems.Read moreRead less
Innovative Methods for Very High Dimensional Problems. Real world problems tend to involve an enormous number of variables. This "curse of dimensionality" poses great difficulty in application areas such as statistics, finance, economics, and physics. These high dimensional problems are not confined to Australia, and there is great demand worldwide for effective and efficient methods to tackle these problems. The novel methods developed here will lead to improvements in prevailing computational ....Innovative Methods for Very High Dimensional Problems. Real world problems tend to involve an enormous number of variables. This "curse of dimensionality" poses great difficulty in application areas such as statistics, finance, economics, and physics. These high dimensional problems are not confined to Australia, and there is great demand worldwide for effective and efficient methods to tackle these problems. The novel methods developed here will lead to improvements in prevailing computational technologies, which will help to enhance Australia's reputation as a leading scientific innovator. The international collaborations will increase the research output of the country, build up the knowledge base in the discipline, draw international interest, and initiate linkages.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100550
Funder
Australian Research Council
Funding Amount
$358,248.00
Summary
Quantum refinement of DNA X-ray structures. DNA carries the genetic map of life and refinement of its x-ray structures is a key tool to understand its functions. Standard refinement, however, relies strongly on empirical geometry constraints, and it is known that these can induce unphysical features. Quantum mechanical (QM) methods have now evolved to a level that offers an intriguing way out of this dilemma. In this project, state-of-the-art QM methods will be applied to DNA x-ray structures, a ....Quantum refinement of DNA X-ray structures. DNA carries the genetic map of life and refinement of its x-ray structures is a key tool to understand its functions. Standard refinement, however, relies strongly on empirical geometry constraints, and it is known that these can induce unphysical features. Quantum mechanical (QM) methods have now evolved to a level that offers an intriguing way out of this dilemma. In this project, state-of-the-art QM methods will be applied to DNA x-ray structures, and a unique quantum refinement scheme will be developed. Such a scheme will provide crystallographers with a new tool to determine DNA structures with greater accuracy and it will offer benefits to many areas of the life sciences that depend on such accurate structures.Read moreRead less