A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can ....A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can be used by engineers in Australia and France to simulate transport phenomena in porous media, which have significant environmental impact. The research will lead to publications in scientific journals and communications at national/international conferences. Research training of postdocs and PhD students is another excellent outcome of the project.Read moreRead less
Innovative Methods for Very High Dimensional Problems. Real world problems tend to involve an enormous number of variables. This "curse of dimensionality" poses great difficulty in application areas such as statistics, finance, economics, and physics. These high dimensional problems are not confined to Australia, and there is great demand worldwide for effective and efficient methods to tackle these problems. The novel methods developed here will lead to improvements in prevailing computational ....Innovative Methods for Very High Dimensional Problems. Real world problems tend to involve an enormous number of variables. This "curse of dimensionality" poses great difficulty in application areas such as statistics, finance, economics, and physics. These high dimensional problems are not confined to Australia, and there is great demand worldwide for effective and efficient methods to tackle these problems. The novel methods developed here will lead to improvements in prevailing computational technologies, which will help to enhance Australia's reputation as a leading scientific innovator. The international collaborations will increase the research output of the country, build up the knowledge base in the discipline, draw international interest, and initiate linkages.Read moreRead less
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
Advanced computational algorithms for three-dimensional systems. This project deals with the development, analysis and implementation of efficient computer algorithms for a range of complex three dimensional systems. Major areas of focus are forward and inverse acoustic and electromagnetic scattering; dynamical and evolution processes in water waves and tumour growth; and the solution of mathematical models on spheres (earth). Potential application areas of the project include defence science ....Advanced computational algorithms for three-dimensional systems. This project deals with the development, analysis and implementation of efficient computer algorithms for a range of complex three dimensional systems. Major areas of focus are forward and inverse acoustic and electromagnetic scattering; dynamical and evolution processes in water waves and tumour growth; and the solution of mathematical models on spheres (earth). Potential application areas of the project include defence science; ocean engineering; medical research; meteorology and global environmental sciences.Read moreRead less
Lifting the curse of dimensionality - bringing together the quasi Monte Carlo and sparse grid methods. This project is expected to lead to improved methods for handling high-dimensional problems (i.e. problems with many variables) that arise in finance, statistics, commerce, physics, and many other fields. In turn this could lead to significant economic benefit, especially to high-value service industries such as the finance industry. By strengthening international collaboration, it will also ....Lifting the curse of dimensionality - bringing together the quasi Monte Carlo and sparse grid methods. This project is expected to lead to improved methods for handling high-dimensional problems (i.e. problems with many variables) that arise in finance, statistics, commerce, physics, and many other fields. In turn this could lead to significant economic benefit, especially to high-value service industries such as the finance industry. By strengthening international collaboration, it will also help to maintain Australia's strong position in international research in the mathematical sciences.Read moreRead less
Novel Mathematical Technologies for Financial Valuation and Risk. The finance industry is a key industry sector in Australia, with a highly qualified and well-paid work force. The profitability and stability of financial institutions rests in part on their ability to accurately and rapidly value innovative financial products and to quantify risk, yet many contemporary financial products are difficult to value quickly and accurately. This project will bring innovative mathematical technologies ....Novel Mathematical Technologies for Financial Valuation and Risk. The finance industry is a key industry sector in Australia, with a highly qualified and well-paid work force. The profitability and stability of financial institutions rests in part on their ability to accurately and rapidly value innovative financial products and to quantify risk, yet many contemporary financial products are difficult to value quickly and accurately. This project will bring innovative mathematical technologies to bear on complex financial problems. It has the potential to improve both the profitability and stability of Australian financial institutions, and to enhance their role regionally and internationally.Read moreRead less
Constrained and Stable Solutions of Nonlinear and Semismooth Equations. In this project, comprehensive models for designing safe power system parameters will be proposed, efficient algorthms for solving these models will be constructed. The new models and algorithms in this project will provide efficient tools to prevent catastrophic events in power systems, which is related with national security. This project will also strengthen collaboration of Australian applied
mathematians with inter ....Constrained and Stable Solutions of Nonlinear and Semismooth Equations. In this project, comprehensive models for designing safe power system parameters will be proposed, efficient algorthms for solving these models will be constructed. The new models and algorithms in this project will provide efficient tools to prevent catastrophic events in power systems, which is related with national security. This project will also strengthen collaboration of Australian applied
mathematians with international researchers and engineering scientists. This is important for the advance of science and technology in
Australia.Read moreRead less
Approximation, Cubature and Point Designs on Spheres. The sphere is important in fields ranging from geophysics to global climate modelling to chemistry to codes for modern communications. This project aims to strengthen and unify key areas of mathematics on the sphere and at the same time provide methods and constructiions of practical significance. The areas of focus are constructive approximation of functions on the sphere, numerical integration on the sphere, and well distributed sets of poi ....Approximation, Cubature and Point Designs on Spheres. The sphere is important in fields ranging from geophysics to global climate modelling to chemistry to codes for modern communications. This project aims to strengthen and unify key areas of mathematics on the sphere and at the same time provide methods and constructiions of practical significance. The areas of focus are constructive approximation of functions on the sphere, numerical integration on the sphere, and well distributed sets of points on the sphere, including spherical designs.Read moreRead less
Nonsmooth Optimization in Constrained Spline Interpolation. Traditional methods based on standard calculus may not work for optimization problems with constraints; however, such problems can be reformulated as nonsmooth problems that need special treatment. The project aims to approach several important problems in constrained spline interpolation and approximation, from the perspective of nonsmooth optimization. The research, which builds upon a recent breakthrough in the approach to the convex ....Nonsmooth Optimization in Constrained Spline Interpolation. Traditional methods based on standard calculus may not work for optimization problems with constraints; however, such problems can be reformulated as nonsmooth problems that need special treatment. The project aims to approach several important problems in constrained spline interpolation and approximation, from the perspective of nonsmooth optimization. The research, which builds upon a recent breakthrough in the approach to the convex best interpolation by the applicant and his collaborators, is expected to provide fundamental theory for Newton-type methods being used for these problems with a vast number of applications in data fitting and curve and surface design.Read moreRead less