Biotransport design for engineering microenvironment in scaffolds. Tissue engineering signifies an exciting opportunity to solve shortage of transplantable tissues. This project targets a critical issue in engineering thick tissue and aims to introduce computational structural optimisation to biotransport problems. The optimal scaffold is expected to create a more desirable microenvironment for better tissue growth.
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less
Advanced Bayesian Inversion Algorithms for Wave Propagation. This project aims to improve algorithms for detecting hidden items by developing new computational mathematical techniques capable of reconstructing the shape and location of objects using electromagnetic waves. This project expects to generate new knowledge in the areas of Bayesian Inversion and computational wave propagation. Expected outcomes of this project are algorithms that can be developed for use in nonintrusive radio wave sec ....Advanced Bayesian Inversion Algorithms for Wave Propagation. This project aims to improve algorithms for detecting hidden items by developing new computational mathematical techniques capable of reconstructing the shape and location of objects using electromagnetic waves. This project expects to generate new knowledge in the areas of Bayesian Inversion and computational wave propagation. Expected outcomes of this project are algorithms that can be developed for use in nonintrusive radio wave security scanners. This should provide benefits such as the capability to scan a crowd without a checkpoint, which will have the potential to improve security in public places.Read moreRead less
Innovative Methods for Very High Dimensional Problems. Real world problems tend to involve an enormous number of variables. This "curse of dimensionality" poses great difficulty in application areas such as statistics, finance, economics, and physics. These high dimensional problems are not confined to Australia, and there is great demand worldwide for effective and efficient methods to tackle these problems. The novel methods developed here will lead to improvements in prevailing computational ....Innovative Methods for Very High Dimensional Problems. Real world problems tend to involve an enormous number of variables. This "curse of dimensionality" poses great difficulty in application areas such as statistics, finance, economics, and physics. These high dimensional problems are not confined to Australia, and there is great demand worldwide for effective and efficient methods to tackle these problems. The novel methods developed here will lead to improvements in prevailing computational technologies, which will help to enhance Australia's reputation as a leading scientific innovator. The international collaborations will increase the research output of the country, build up the knowledge base in the discipline, draw international interest, and initiate linkages.Read moreRead less
From Snowball Earth to Animals: the Influence of Mantle Dynamics. This project aims to investigate how solid Earth processes contributed to ‘Snowball Earth’ events around 700 million years ago and to the explosion of complex life 540 million years ago, which will shed light on our origin as a species. The approach consists of merging cutting-edge models of the plate-mantle system with the global rock record. The intended outcome is to understand relationships between mantle convection, the behav ....From Snowball Earth to Animals: the Influence of Mantle Dynamics. This project aims to investigate how solid Earth processes contributed to ‘Snowball Earth’ events around 700 million years ago and to the explosion of complex life 540 million years ago, which will shed light on our origin as a species. The approach consists of merging cutting-edge models of the plate-mantle system with the global rock record. The intended outcome is to understand relationships between mantle convection, the behaviour of the magnetic field, global sea levels, continental-scale topography, and the composition of the ocean and atmosphere. Expected significant benefits include building capacity in Earth Sciences and the development of new models that can be used to explore the mineral endowment of the Australian crust.Read moreRead less
Computational enzymology: exploring the free energy landscape of enzymatic catalysis. Most biochemical reactions depend on enzyme catalysis and understanding how enzymes work at the molecular level remains a central question. This project will develop a suite of computational models to study the mechanisms of enzyme-catalysed reactions and such knowledge holds promise for technological benefits in the form of new drugs and novel catalysts.
First Principles Design of Second-Generation Protein Stains. Proteomics is an emerging technology which has the potential to revolutionize modern biology and medicine. Extremely sensitive protein stains are a key proteomics technology, and in conjunction with gel electrophoresis, they facilitate the rapid and quantitative detection of all polypeptides in a cell. However, the tools of proteomics must rapidly advance (cheaper, greater sensitivity, more reliable, safer to handle) before the techn ....First Principles Design of Second-Generation Protein Stains. Proteomics is an emerging technology which has the potential to revolutionize modern biology and medicine. Extremely sensitive protein stains are a key proteomics technology, and in conjunction with gel electrophoresis, they facilitate the rapid and quantitative detection of all polypeptides in a cell. However, the tools of proteomics must rapidly advance (cheaper, greater sensitivity, more reliable, safer to handle) before the technology can mature to the stage where its full potential is realized. We will enable the evolution of proteomics by devising second generation fluorescent protein stains, using the environmentally-friendly natural product, epicocconone, as our design platform.Read moreRead less
Persistent Triplet Carbenes. Viable or Not? Triplet carbenes have significant potential real world applications, such as in modern electronics. However, they are highly reactive (lifetimes typically < 1 day), and this has stymied their development. Can I design so called persistent triplet-carbenes, which have significant lifetimes? I will try to using computer chemistry. In doing so, I will provide synthetic chemists with 'high-value' targets for preparation, hence saving tax dollars and minimi ....Persistent Triplet Carbenes. Viable or Not? Triplet carbenes have significant potential real world applications, such as in modern electronics. However, they are highly reactive (lifetimes typically < 1 day), and this has stymied their development. Can I design so called persistent triplet-carbenes, which have significant lifetimes? I will try to using computer chemistry. In doing so, I will provide synthetic chemists with 'high-value' targets for preparation, hence saving tax dollars and minimizing creation of environmentally damaging waste. Read moreRead less
Computational design for engineering micro/nanotopography. Micro/nanotopography and associated characteristics has major influences in several emerging areas of environmental, biomedical and energy engineering. This project will develop a new computational framework for topographical design and fabrication. It will create new research opportunities and technological innovation for the future development.