Response of Proteins to External Non-Ionising Radiation: an Experimental and Computer Modelling Investigation. The expanding use of digital technologies such as mobile phones has led to major health concerns about the effects of non-ionising pulsed radiation exposure which has been shown to produce instantaneous temperature rises undetectable by normal thermometry. The health implications of exposure are not understandable without establishing molecular mechanisms by which pulsed microwaves can ....Response of Proteins to External Non-Ionising Radiation: an Experimental and Computer Modelling Investigation. The expanding use of digital technologies such as mobile phones has led to major health concerns about the effects of non-ionising pulsed radiation exposure which has been shown to produce instantaneous temperature rises undetectable by normal thermometry. The health implications of exposure are not understandable without establishing molecular mechanisms by which pulsed microwaves can cause biological effects. We aim to establish methods for studying the molecular mechanisms of protein structural and energetic changes occurring due to non-ionising radiation. The results will help our industry partner to design specific drugs as well as formulate a scientifically based standard for microwave utilisation.Read moreRead less
Robust and Scalable Autonomous Landing for Drones. The aim of this project is to develop a transformative robust and scalable autonomous landing system for drones. This is the critical missing technology needed to unleash exponential growth in a potentially enormous drone delivery industry by enabling a multitude of applications to deliver goods and supplies via drones to a wide range of destinations in Australia and the world in a timely, flexible and accurate manner. Such an autonomous landi ....Robust and Scalable Autonomous Landing for Drones. The aim of this project is to develop a transformative robust and scalable autonomous landing system for drones. This is the critical missing technology needed to unleash exponential growth in a potentially enormous drone delivery industry by enabling a multitude of applications to deliver goods and supplies via drones to a wide range of destinations in Australia and the world in a timely, flexible and accurate manner. Such an autonomous landing solution would revolutionise drone technology, and propel Australia to the forefront of technology innovation. This project would benefit not only large scale delivery by drone in urban and suburban areas of Australia but also long distance delivery via drone to remote areas of Australia.Read moreRead less
Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
An extensible framework for analysis of Java language-based security conformance. Java is a programming language and platform running on 3 billion devices. While Java provides a sandbox-based security architecture within the Java Class Library to protect systems from untrusted code downloaded from Internet, it cannot defend against implementation bugs that occur in the Java Class Library. The goal of this project is to provide a formal model of the Java security architecture, which can be used b ....An extensible framework for analysis of Java language-based security conformance. Java is a programming language and platform running on 3 billion devices. While Java provides a sandbox-based security architecture within the Java Class Library to protect systems from untrusted code downloaded from Internet, it cannot defend against implementation bugs that occur in the Java Class Library. The goal of this project is to provide a formal model of the Java security architecture, which can be used by program analysers to identify faulty or insufficient security checks in the Java Class Library that may lead to the sandbox being bypassed.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Optimising experimental design for robust product development: a case study for high-efficiency energy generation. This project tackles key mathematical challenges to provide a powerful new methodology and tool for optimal product design, making smarter use of limited information, minimising costly trials, shortening the product cycle, and boosting the competitiveness of both the Australian manufacturing and alternative energy production industries.
A fundamental study of milk ultrafiltration. The Dairy Industry is one of Australia's largest domestic and export industries. The fundamental knowledge and models developed in this project will be used to optimise dairy membrane processing. This will reduce water and energy use to improve the global competitiveness and reduce the environmental impact of the Australian Dairy Industry.
Talking about place: tapping human knowledge to enrich national spatial data sets. Place descriptions are a common way for people to describe a location, but no current tools are smart enough to understand them. Emergency call centres are risking lives, users of navigation or web services are frustrated and addressing these problems costs billions of dollars per year. This project comes with a novel, interdisciplinary approach to automatically interpret human place descriptions and will develop ....Talking about place: tapping human knowledge to enrich national spatial data sets. Place descriptions are a common way for people to describe a location, but no current tools are smart enough to understand them. Emergency call centres are risking lives, users of navigation or web services are frustrated and addressing these problems costs billions of dollars per year. This project comes with a novel, interdisciplinary approach to automatically interpret human place descriptions and will develop novel methods to capture placenames with their meaning for smarter databases and automatic interpretation procedures. This acquired knowledge will be an important step forward for Australia's data custodians and users. Australia's location information industry will gain a significant advantage on a highly competitive global market.Read moreRead less