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Hyperbaric Oxygen In Lower Limb Trauma: A Randomised Controlled Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$729,288.00
Summary
HOLLT is an international multi-centre randomised clinical trial aimed at assessing the impact of hyperbaric oxygen therapy (HBO) on acute complication rates and long term outcomes following severe musculoskeletal trauma. The study will enrol 250 patients with severe, open tibial fractures over a 2-3 year period. Enrolled subjects will be followed up for 2 years with radiological, clinical and quality of life measures.
Severe Malaria In Children In Papua New Guinea: A Longitudinal Study Of Pathophysiology, Management And Outcome
Funder
National Health and Medical Research Council
Funding Amount
$484,808.00
Summary
The features of severe infection in children living in tropical countries may not allow differentiation between malaria and bacterial-viral causes. This can create significant problems with deciding on appropriate management. In addition, the main complications of malaria such as coma, increased acid levels in the blood and anaemia are not well understood. We plan to characterise infections in Papua New Guinean children in detail and explore mechanisms behind important malarial complications.
Investigating The Mechanisms That Increase Nerve-evoked Vasoconstriction Following Spinal Cord Injury
Funder
National Health and Medical Research Council
Funding Amount
$372,547.00
Summary
People with spinal cord injury not only lose control of their arms and legs but also lose control of their bladder and bowel. They also have poor control of blood pressure and an overfull bladder or bowel can lead to dangerously high blood pressure. In this project, we are investigating how this abnormal high blood pressure is generated. The aim is to develop treatments which target the mechanisms which increase the blood pressure responses elicited by the bladder and bowel.
Development And Clinical Evaluation Of A Depth Of Anaesthesia Monitor
Funder
National Health and Medical Research Council
Funding Amount
$424,785.00
Summary
Waking up during surgery (awareness under anaesthesia) is a frightening reality for some patients. Although uncommon (occurring in about 1 in 1000 operations), it remains one of the main concerns of patients before their surgery. Recent studies (including our own) have demonstrated that processed EEG monitoring using bispectral index (BIS) can markedly reduce the risk of awareness. Other EEG monitors are being developed, but each have weaknesses. As approximately two million Australians have a g ....Waking up during surgery (awareness under anaesthesia) is a frightening reality for some patients. Although uncommon (occurring in about 1 in 1000 operations), it remains one of the main concerns of patients before their surgery. Recent studies (including our own) have demonstrated that processed EEG monitoring using bispectral index (BIS) can markedly reduce the risk of awareness. Other EEG monitors are being developed, but each have weaknesses. As approximately two million Australians have a general anaesthetic each year, about 2000 will suffer an episode of awareness. More than 60 million people around the world have an anaesthetic, and so the problem is substantial. This suggests the potential benefits (health outcomes, commercial gains) are very great. In 2000 less than 5% of US hospitals used BIS monitoring; the current figure in the US is about 69% of the best-rated hospitals (US News and World Report) and 78% of teaching hospitals. A similar rapid growth is occurring in Australia and Europe. We are working with a successful Australian Company (Compumedics Ltd) to develop a better awareness monitor. We plan studies in groups of patients have surgery.Read moreRead less
Development And Validation Of A Health Policy Simulation Model For Type 1 Diabetes.
Funder
National Health and Medical Research Council
Funding Amount
$409,199.00
Summary
This proposal brings together an international multi-disciplinary team to develop and validate a health economic computer simulation model for type 1 diabetes and its complications. It examines the impact of diabetes on costs as well as quality of life. Outcomes generated by the model will inform health policy decisions regarding allocation of resources for people with type 1 diabetes such as cost-effectiveness analysis of new treatments and technologies.
Development Of Novel Medical Therapies To Cure Ectopic Pregnancies
Funder
National Health and Medical Research Council
Funding Amount
$601,156.00
Summary
Ectopic pregnancies are conceptions implanting outside the womb, mainly the fallopian tube. They are pathological, and can erode straight through the tube into large blood vessels causing fatal bleeding and death. We plan to assess three medication based approaches to treat this condition that would avoid surgery entirely. If we succeed, and subsequently translate one or more of these treatments to the clinic, it would revolutionise management of this serious gynaecological emergency.
Quantifying The Burden, Understanding The Predictors, And Improving The Outcomes Of Non-fatal Injury
Funder
National Health and Medical Research Council
Funding Amount
$459,270.00
Summary
This Career Development Fellowship will use the analysis of existing (and continuing data collection), and key health data linkages to improve understanding of the outcomes of injury survivors and factors contributing to outcomes. The outcomes of this research program will be improved injury burden estimates, and better health outcomes for trauma survivors through informing evidence-based clinical guidelines and trauma care delivery.
DEVELOPMENT OF FOLDING IN THE FETAL CEREBRAL CORTEX – IDENTIFYING FUNDAMENTAL MECHANISMS AND THEIR SUSCEPTIBILITY TO DISRUPTION IN NORMAL AND ABNORMAL PREGNANCY
Funder
National Health and Medical Research Council
Funding Amount
$607,742.00
Summary
During pregnancy, the surface of the fetal brain gradually develops the ridges, valleys, and folds that are the characteristic feature of our highly developed brain. However, this process can be disturbed if birth occurs prematurely, the unborn baby suffers oxygen starvation in the uterus, or the mother consumes alcohol. In this project we are determining how cell migration results in the development of brain surface folding, and how hypoxia and maternal alcohol consumption affect these importan ....During pregnancy, the surface of the fetal brain gradually develops the ridges, valleys, and folds that are the characteristic feature of our highly developed brain. However, this process can be disturbed if birth occurs prematurely, the unborn baby suffers oxygen starvation in the uterus, or the mother consumes alcohol. In this project we are determining how cell migration results in the development of brain surface folding, and how hypoxia and maternal alcohol consumption affect these important processes.Read moreRead less
Molecular Genetic Risk Factors And Mechanisms In Blinding Eye Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This project aims to understand the genetic causes of blinding eye diseases. We have recently identified genetic variation that contributes to the risk of glaucoma and diabetic eye disease. We are exploring the mechanisms through which this leads to disease by looking at differences in the genes in patients with disease compared to unaffected individuals. We hope to be able to identify genes that could be the target of new therapies to prevent blindness and visual impairment in the community.