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Investigating The Relationship Between Depression, Anxiety And Nausea And Vomiting During Pregnancy: Causation Or Shared Liability?
Funder
National Health and Medical Research Council
Funding Amount
$600,874.00
Summary
Recent studies showing women who experience severe Nausea and vomiting during pregnancy (NVP) have higher rates of Anxiety and Depression prior to pregnancy have revived earlier hypotheses that NVP may have a psychogenic component. We hypothesize that Anxiety and Depression do not play a causal role in NVP but rather, the relationship is due to shared risk from genetic effects that influence both traits. We will test this hypothesis using genetic and epidemiological approaches.
Functional Contribution Of Fetal Microchimeric Cells In Transgenic Models Of Maternal Tissue Repair In And After Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$542,462.00
Summary
Fetal stem cells cross into the mother during pregnancy and persist lifelong in her tissues. To determine whether helpful or harmful, we will study how these cells contribute to healing both after acute injury and in chronic genetic models like brittle-bone disease and muscular dystrophy. This research will inform long-term consequences of pregnancy, important for women's health and longevity, and help develop a promising form of stem cell therapy.
Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
STudy Of Risk Assessment To Reduce Complications In Patients Following Noncardiac SurgerY (STRATIFY)
Funder
National Health and Medical Research Council
Funding Amount
$436,000.00
Summary
Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduce ....Cardiac problems account for many complications in patients undergoing major non-cardiac surgery, and even apparently minor cardiac damage is a marker of high risk for subsequent adverse events. Unfortunately, while money and effort is expended on identifying patients at risk, the appropriate response to this risk is quite unclear. The performance of bypass surgery or balloon angioplasty in order to treat the underlying coronary disease of at-risk patients is used in other situations, and reduces longterm risk. However, in many patients undergoing major noncardiac surgery, this approach may be inappropriately aggressive, as these patients are often elderly, have other diseases that make heart operations more difficult and risky than usual, and in any case may have a reduced life expectancy from the disease necessitating the operation. As the most critical issue is to ensure that patients undergo their surgery uneventfully, an alternative is the use of intensive medical therapy to protect the heart. This multicentre study, based at Brisbane hospitals that perform large numbers of major operations, will follow up patients for complications, and outcome (including quality of life) will be assessed six months after the operation. We will address two important questions about the efficacy and cost of risk reduction strategies. First, in patients at higher levels of risk and with a positive stress test, could a combination of medical therapy designed to protect the heart be as effective as current approaches, which include the performance of bypass surgery or coronary balloon angioplasty? Second, in patients identified as being at some risk - but low risk - are drugs sufficiently effective to avoid the need for further testing to quantify risk? As the population continues to age, the numbers of at risk patients undergoing major surgery will increase, and answers to these questions will provide important information to guide their management.Read moreRead less
Developmental Pathways to Intimate Partner Homicide: Understanding Individual and Situational Dimensions. Intimate partner homicide is a serious public health and safety issue. This project will have several benefits. The findings will extend understanding of pathways leading to partner homicide. The findings will contribute to improved decision-making models by police and social welfare agencies. With more valid information about the changing characteristics leading to partner homicide, the fin ....Developmental Pathways to Intimate Partner Homicide: Understanding Individual and Situational Dimensions. Intimate partner homicide is a serious public health and safety issue. This project will have several benefits. The findings will extend understanding of pathways leading to partner homicide. The findings will contribute to improved decision-making models by police and social welfare agencies. With more valid information about the changing characteristics leading to partner homicide, the findings will foster more effective and efficient responses. Additionally, the findings will inform victims of partner violence of risks related to escalation toward fatal outcomes and should facilitate help seeking behaviour. Collectively, project findings should expand understanding, improve service delivery and save lives.
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The social determinants of childhood injury. Child hood injury is a preventable problem of major importance. This project will provide a comprehensive, research-based policy solution that will minimise death and disability among children zero to three years of age.
Physiotherapist Led Stress Inoculation Intervention Integrated With Exercise For Acute Whiplash Injury
Funder
National Health and Medical Research Council
Funding Amount
$518,960.00
Summary
Physical and mental health outcomes following whiplash injury due to a road traffic crash are poor. Early stress system responses are associated with poor recovery. This study will investigate the effectiveness of a physiotherapist led stress inoculation intervention integrated with currently recommended exercise rehabilitation to improve health outcomes after whiplash injury.
Comparison Of Cognitive-behavioural Treatments For Children With PTSD Following An Accidental Injury: A Multi-site RCT.
Funder
National Health and Medical Research Council
Funding Amount
$359,111.00
Summary
Children who experience a traumatic event are at increased risk of developing Post traumatic stress disorder (PTSD). Despite the significant consequences, and the poor prognosis of this disorder, few evaluations of interventions for PTSD in children exist. This project will compare two active treatments (child vs. family-focused cognitive behaviour therapy) for children experiencing PTSD following an accidental injury (the most common category of traumatic events experienced by children).
Stem Cell Treatment For Neonatal Hypoxic Ischaemic Encephalopathy
Funder
National Health and Medical Research Council
Funding Amount
$954,195.00
Summary
Hypoxic-ischaemic encephalopathy occurs when the fetus receives inadequate oxygen in labour and many babies die or have brain damage. Stem cell therapy might save these babies from brain damage but there are many unknowns, such as which stem cells to use and how many. Through our skills in stem cells and measuring the rescued brain following injury, we will determine the necessary details for the most effective stem cell therapy to be ready to immediately test the treatment in a RCT in babies.