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The Relationship Between Non-Alcoholic Fatty Liver Disease And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
Non alcoholic Fatty Liver Disease (NAFLD) threatens to become a major public health problem. Its increasing prevalence is associated with parallel increases in obesity and diabetes. This study aims to understand the mechanisms involved in progression to liver failure and liver cancer in the setting of diabetes and the impact of NAFLD on blood sugar levels and diabetes complications (esp. cardiovascular). Using a recently developed animal model of type 2 diabetes and fatty liver, it will better d ....Non alcoholic Fatty Liver Disease (NAFLD) threatens to become a major public health problem. Its increasing prevalence is associated with parallel increases in obesity and diabetes. This study aims to understand the mechanisms involved in progression to liver failure and liver cancer in the setting of diabetes and the impact of NAFLD on blood sugar levels and diabetes complications (esp. cardiovascular). Using a recently developed animal model of type 2 diabetes and fatty liver, it will better define a novel therapeutic agent.Read moreRead less
There is a link between maternal lipids and newborn weight as well as other adverse pregnancy outcomes. Maternal lipids _ serum level, dietary intake and change in maternal lipids during pregnancy may be important in determining not only immediate pregnancy and newborn outcomes but also longer term problems for mother and child. As yet, we do not know whether altering maternal lipids will change outcomes or how to influence lipid levels in practice or how best to approach this.
Targeted Nanoparticle Delivery Of Agents To The Placenta To Treat Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Preeclampsia, one of the most serious complications of pregnancy, affects around 3-8% of all pregnancies. Sadly, there is no treatment. We have developed a new technique to deliver treatments only to the placenta, sparing the mother and baby from side effects. We will test whether this technique can treat the source of preeclampsia, the placenta, in mouse models and human tissue samples in the laboratory. This work may offer possibilities of new treatments to other pregnancy complications.
HtrA4-induced Endothelial Dysfunction In Early-onset Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$86,073.00
Summary
Preeclampsia (PE), a life-threatening disorder of pregnancy, is characterized by a sudden increase in blood pressure in association with wide-spread endothelial dysfunction. Placenta-derived factors are believed to cause PE development. Our recent studies have identified that HtrA4, a placenta-specific serine protease may contribute to endothelial dysfunction. This study will investigate the mechanisms of HtrA4-induced endothelial dysfunction.
Health Consequences For Mother And Baby Of Substantial Pre-conception Weight Loss In Obese Women
Funder
National Health and Medical Research Council
Funding Amount
$93,418.00
Summary
Obesity (BMI >30kg/m2) is now very common in women of child-bearing age.There is strong evidence that maternal obesity increases the rate of pregnancy complications, and affects the growth and well-being of the fetus in-utero. This project aims to determine how substantial pre-conception weight loss, achieved using a Very Low Energy Diet (VLED), impacts maternal and neonatal health outcomes.
Sharpening The Epidemiological Sword Against Ocular Trauma To Help Improve Management And Predict The Visual Outcomes, Contributing To The Development Of Prevention
Funder
National Health and Medical Research Council
Funding Amount
$59,168.00
Summary
Eye injury is the leading cause of monocular blindness internationally. Vision loss has devastating consequences, both financial and social. My research aims to develop a comprehensive international register for eye injury. Working with key international partners we will conduct a large-scale retrospective review to validate our data collection tool. Our aim is to revise outdated methods of scoring eye injury to better predict outcomes and improve management and treatment of eye injury.
Maternal Ophthalmic Artery Doppler Waveform Analysis In The Assessment And Management Of Pre-eclampsia
Funder
National Health and Medical Research Council
Funding Amount
$94,758.00
Summary
Pre-eclampsia is the commonest serious medical problem in pregnancy. Mothers who have this condition are at risk of seizures, stroke and other neurological problems, which can cause death or long-term morbidity. Treatments for pre-eclampsia aim to prevent these problems. Through ultrasound imaging of a blood vessel at the back of the eye, this study will provide new insights into how these treatments change the brain's blood supply in mothers with pre-eclampsia.
Up to 50% of patients having surgery take regular medications and almost half of these patients have their medications stopped at the time of surgery. The interruption of their regular medications during this period exposes patients to associated complications. The project aims to improve the management of patients’ regular medications at the time of surgery, especially when they are fasting or nil by mouth, via a bundle of interventions that include education, reminders and audit/feedback.
Epidemiological And Molecular Risk Factors For Diabetic Retinopathy Blindness.
Funder
National Health and Medical Research Council
Funding Amount
$61,988.00
Summary
Diabetic retinopathy (DR) is the leading cause of blindness in working age adults, affecting 30% of Australians with diabetes. Patients at most risk of blindness are the focus of this project. We aim to (1) investigate why some people are more likely to develop blinding DR by looking at genetic difference between diabetic patients with and without DR; and, (2) help to understand why Indigenous Australians are so over represented in this subset of diabetic patients going blind from DR.