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Researching Functioning, Disability And Rehabilitation: Translation Into Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$481,167.00
Summary
Appropriate support, including responsive health services, is a key to assisting people with disabilities. Disability is most common in older age but acquired disability, particularly following injury, is important in younger people. This research proposal investigates functioning, disability and rehabilitation across the adult lifespan and aims to translate research findings into policy and practice.
Translating New Therapeutics And Diagnostics For Major Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$481,156.00
Summary
My research is focussed on tackling major complications of pregnancy that are a threat to the lives of both mother’s and babies. We are developing new drug treatments for ectopic pregnancy (a dangerous condition where the pregnancy implants in the Fallopian tube), and preeclampsia (a condition where toxins leak out of the placenta into mum's blood, and can seriously injure many of mum's major organs). We are also generating a blood test that may help women avoid the tragedy of a stillbirth.
Optimization Of Glycaemic Control And Prevention Of Hypoglycaemia And Microvascular Complications In Children And Adolescents With Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$452,051.00
Summary
Type 1 diabetes is a complex life-long disease that has onset in the young and carries a significant burden. Good management is crucial as it helps prevent the serious long term complications of the disease such as blindness and kidney disease. Low blood glucose or hypoglycaemia is a common side effect of insulin treatment. This research aims to explore ways to treat the disease more effectively, prevent hypoglycaemia and other diabetes complications and in so doing improve the outcomes for youn ....Type 1 diabetes is a complex life-long disease that has onset in the young and carries a significant burden. Good management is crucial as it helps prevent the serious long term complications of the disease such as blindness and kidney disease. Low blood glucose or hypoglycaemia is a common side effect of insulin treatment. This research aims to explore ways to treat the disease more effectively, prevent hypoglycaemia and other diabetes complications and in so doing improve the outcomes for young people with diabetes.Read moreRead less
Improving Outcomes Of Diabetes And Related Conditions For Indigenous Australians: Causes, Intervention, System Change
Funder
National Health and Medical Research Council
Funding Amount
$274,218.00
Summary
My research program is focused on improving outcomes of diabetes and related conditions for Indigenous Australians through: (i) describing causal pathways; (ii) addressing health system change; and (iii) conducting clinical intervention studies.
Advances in anaesthesia and perioperative medicine have resulted in safer care and better quality outcomes for patients having major surgery. Such advances need to be based on good quality evidence, coming from large randomised clinical trials. This research program will study, publish and disseminate information from studies of new drugs and techniques that improve the care of patients undergoing surgery.
Improving Clinical Understanding And Management Of Tendinopathy
Funder
National Health and Medical Research Council
Funding Amount
$487,621.00
Summary
Painful tendons occur in people of all ages. Treatment outcomes are variable and many people are left with chronic pain and limited capacity to be active. This research will investigate the development of tendinopathy, the cause of tendon pain and examine imaging methods to improve management. This research expects to demonstrate that tendon injury develops during puberty, that the brain has a central role in tendon pain, and that regular monitoring of tendon structure can improve outcomes.
Mild traumatic brain injury (TBI) is a leading cause of death and disability in Australia, especially in young populations. Although many patients recover uneventfully following mild TBI, complications such as prolonged symptoms, depression and cognitive deterioration may occur. With considerable advancements in neuroimaging and cognitive assessment in recent years, newer techniques may provide a window to directly observe changes that accompany mild TBI.
Mild Traumatic Brain Injury And The Risk Of Long-term Neurodegenerative And Neurobehavioural Disease
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
Considerable media attention surrounds the potential for long-term problems in individuals with high exposure to head impacts such as seen in sporting, civilian and/or military contexts. This study examines the long-term effects of mild traumatic brain injury (mTBI) and helps close the current knowledge gap of the impact of this disorder on individuals. There are no long term trials to answer the critical question of whether mild TBI causes long term problems in the brain.
Improved Patient Outcomes By Early Intervention With Therapeutic Cooling For Patients With Severe Traumatic Brain Injury, And By Optimising Patient Blood Transfusion Practice In Critically Ill Patients.
Funder
National Health and Medical Research Council
Funding Amount
$380,450.00
Summary
First, a large multicentre trial (POLAR) will complement my previous successful trials in traumatic brain injury (TBI) patients and will establish whether active therapeutic cooling, commenced early after brain injury and continued in intensive care units, will achieve its promise of improving patient outcomes. Second, a national multicentre trial (TRANSFUSE) will establish whether transfusing blood units with a shorter than usual storage time will improve patient outcomes.
Modernizing The Knowledge Base For Reproductive Health Care: Individual Patient Data Meta-analysis As The New Standard For Evidence Synthesis In Reproductive Health.
Funder
National Health and Medical Research Council
Funding Amount
$575,662.00
Summary
Characteristics of sick persons differ, and criteria that have been used to include them in studies may not match the individual profile of individuals who typically present to the health system. I propose a step towards more personalised medicine, which is new in the field of reproductive health. In a global collaboration, we plan to collect individual participant data of studies, and develop clinical rules and guidelines that tailor the individual profile of the sick individual.