The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Congestion control in complex networks with higher-order interactions. Traffic congestion significantly costs the Australian economy and environment. This project aims to develop ground-breaking network models of urban traffic systems to build a new congestion control framework. The purpose of network modelling is to capture the interdependence between different parts of traffic systems, which facilitates studying congestion cascade within the network. The project expects to generate next genera ....Congestion control in complex networks with higher-order interactions. Traffic congestion significantly costs the Australian economy and environment. This project aims to develop ground-breaking network models of urban traffic systems to build a new congestion control framework. The purpose of network modelling is to capture the interdependence between different parts of traffic systems, which facilitates studying congestion cascade within the network. The project expects to generate next generation of network models for more effective congestion control. Expected outcomes include novel congestion control technologies that adjust traffic signals in real-time to optimally utilise the available road space. This should provide significant economic and environmental benefits to Australians by easing traffic jams.Read moreRead less
Symmetries in real and complex geometry. This project concerns an important area of abstract modern geometry. The results and techniques of the project will lead to significant progress in this area. It will benefit the national scientific reputation, strengthen the research profile of the home institutions, and provide training to young researchers.
Optimising Heart Disease Prevention And Management
Funder
National Health and Medical Research Council
Funding Amount
$4,647,175.00
Summary
As we become older and risk factors such as obesity become more common, our biggest contributor to death and disability, cardiovascular disease (including heart disease), will continue to exert an enormous burden on our health care system and society. We will extend our ground-breaking research on multidisciplinary teams to create new and innovative health care programs to optimise the prevention and management of new heart disease and chronic forms of heart disease.
Cultural change in its environmental context: exploring, interpreting, and managing archaeologically rich, large-scale cultural landscapes in the Mediterranean Basin. (1) Production of a Holocene climate history and evaluation of long-term human response to environmental change in Mediterranean to continental climate zones. (2) Development of relationships with international researchers, including leading scholars from Italy, Bulgaria, the United States, and the Netherlands. (3) Extension of Aus ....Cultural change in its environmental context: exploring, interpreting, and managing archaeologically rich, large-scale cultural landscapes in the Mediterranean Basin. (1) Production of a Holocene climate history and evaluation of long-term human response to environmental change in Mediterranean to continental climate zones. (2) Development of relationships with international researchers, including leading scholars from Italy, Bulgaria, the United States, and the Netherlands. (3) Extension of Australia's leadership in Mediterranean archaeology to the Balkans through building institutional relationships and initiating a presence in Bulgaria (arguably the most promising country in its region for archaeological research). (4) Development of innovative remote sensing methods for archaeological reconnaissance with wide applicability, including in Australian contexts and by other Australian research projects.Read moreRead less
Periodontal Disease And Chronic Kidney Disease Among Aboriginal Adults; An RCT
Funder
National Health and Medical Research Council
Funding Amount
$1,035,550.00
Summary
Chronic Kidney Disease is a growing public health concern in Australia, especially among Aboriginal populations. It is associated with progression to end stage kidney disease requiring dialysis, cardiovascular disease burden and high mortality. This study will use a randomised controlled trial design to determine if comprehensive periodontal therapy reduces progression of kidney disease among Aboriginal adults with chronic kidney disease residing in Central Australia.
Defining Epigenetic Predictors Of Long-term Outcomes Of Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$409,408.00
Summary
On average, those born premature do worse health-wise than those born at term. However, some do worse than others. Our aim is to identify these people at birth to better help doctors and parents to closely monitor their health. For this, we will be “reading the diary of pregnancy” in the molecules added to chromosomes in blood during pregnancy in young adults with will characterised states of health. We will analyse DNA from blood that we will extract from stored heel prick spots.
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less
Can One Health Strategies Be More Effectively Implemented Through Prior Identification Of Public Values?
Funder
National Health and Medical Research Council
Funding Amount
$585,331.00
Summary
Emerging infectious diseases (EIDs) are a significant risk to our region. One Health approaches to EIDs emphasize connections between human,animal and ecological health, enhancing capacity for disease prediction and intervention. This project will examine existing EID legislation,identify social and ethical barriers to effective EID risk governance and create a comprehensive statement of values to ensure the acceptability of One Health approaches to EID control to the Australian community.
Developing A New Strategy For Treating Demyelinating Peripheral Diseases
Funder
National Health and Medical Research Council
Funding Amount
$496,250.00
Summary
Incomplete remyelination is a significant component of the persistent clinical disability of peripheral demyelinating neuropathy, contributing to conduction deficits and the secondary axonal damage. A crucial therapeutic challenge is to identify ways to promote remyelination. This project aims to develop a new strategy and a novel clinically relevant target for treating peripheral demyelinating neuropathy.