Discovery Early Career Researcher Award - Grant ID: DE150101637
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Plasmonic nanofocusing for super-resolution DNA imaging. Plasmonics (waves in a metal's electrons) can focus light to extreme concentrations that enable imaging techniques to resolve features well beyond the optical barrier known as the diffraction limit. This project aims to develop a routine methodology capable of extracting precise information from single DNA molecules by incorporating plasmonic components into a lab-on-a-chip device for use under conventional optical microscopes. The configu ....Plasmonic nanofocusing for super-resolution DNA imaging. Plasmonics (waves in a metal's electrons) can focus light to extreme concentrations that enable imaging techniques to resolve features well beyond the optical barrier known as the diffraction limit. This project aims to develop a routine methodology capable of extracting precise information from single DNA molecules by incorporating plasmonic components into a lab-on-a-chip device for use under conventional optical microscopes. The configuration would have the convenience and technological maturity associated with microscopes whilst being able to capture details of biomolecules with unprecedented detail. New DNA analyses will be made possible by the platform, such as studying the genomic diversity within a population of tumour cells.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100704
Funder
Australian Research Council
Funding Amount
$355,000.00
Summary
Development of Two-Dimensional MnO2 Nanosheets for a theranostic platform. This project aims to develop a novel diagnostic and therapeutic nanoplatform for cancer treatment that will improve cancer diagnosis and monitoring of treatment and reduce the side-effects of chemotherapy. The platform, based on biocompatible, ultrasmall and targeted two-dimensional manganese-oxide nanosheets, aims to combine simultaneous targeting, stimuli-responsive magnetic resonance imaging and drug release and delive ....Development of Two-Dimensional MnO2 Nanosheets for a theranostic platform. This project aims to develop a novel diagnostic and therapeutic nanoplatform for cancer treatment that will improve cancer diagnosis and monitoring of treatment and reduce the side-effects of chemotherapy. The platform, based on biocompatible, ultrasmall and targeted two-dimensional manganese-oxide nanosheets, aims to combine simultaneous targeting, stimuli-responsive magnetic resonance imaging and drug release and delivery. This should enable precise imaging of tumour tissues and enhanced drug delivery triggered by the physiological tumour microenvironment. The translation of this technology into clinical practice is likely to have significant benefits for the efficient treatment of cancer.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100146
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future re ....Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future research fields will benefit from the presence of this instrument, which will enhance Australia's competitiveness in nanotechnology research and development. Training of PhD and graduate students in this area is essential to exploit the potentiality of nanotechnology for the future benefit of Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100345
Funder
Australian Research Council
Funding Amount
$384,616.00
Summary
Harnessing nanotechnology to unravel extracellular vesicle heterogeneity. This project aims to develop a suite of innovative nanotechnologies to study extracellular vesicles with unprecedented depth of analysis and single particle resolution. This project expects to generate new knowledge in the emerging field of extracellular vesicle (EV) biology, as well as cell biology, using advanced nanofabrication and nanoscopic fluid flows to advance understanding of EV heterogeneity and how phenotypic va ....Harnessing nanotechnology to unravel extracellular vesicle heterogeneity. This project aims to develop a suite of innovative nanotechnologies to study extracellular vesicles with unprecedented depth of analysis and single particle resolution. This project expects to generate new knowledge in the emerging field of extracellular vesicle (EV) biology, as well as cell biology, using advanced nanofabrication and nanoscopic fluid flows to advance understanding of EV heterogeneity and how phenotypic variations affect their role in cellular processes. Expected outcomes include a universal technology platform to study extracellular vesicles and other bioparticles, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less