Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Genealogy and Topology: A Constellational Comparison of Nietzsche and Heidegger. This research is fundamental in character addressing basic questions about the nature and history of philosophy. It will have direct academic benefits in advancing disciplinary knowledge, in enhancing the reputation of Australian philosophy in Germany and internationally, and in promoting contact between Australian and German philosophers, but is also likely to have longer term benefits in furthering our understandi ....Genealogy and Topology: A Constellational Comparison of Nietzsche and Heidegger. This research is fundamental in character addressing basic questions about the nature and history of philosophy. It will have direct academic benefits in advancing disciplinary knowledge, in enhancing the reputation of Australian philosophy in Germany and internationally, and in promoting contact between Australian and German philosophers, but is also likely to have longer term benefits in furthering our understanding of the nature of concepts, and of conceptual creativity.Read moreRead less
Neo-liberalism and the Decline of Democratic Governance: A Problem of Institutional Design? How well Australia's democracy is working is critical both for national policy making and for citizenship. Many scholars argue that populism is in the ascendant, political parties have weakened and that public confidence in political leaders has diminished. This project will provide an authoritative test of these propositions. If they are established, it will identify the ways democratic governance can be ....Neo-liberalism and the Decline of Democratic Governance: A Problem of Institutional Design? How well Australia's democracy is working is critical both for national policy making and for citizenship. Many scholars argue that populism is in the ascendant, political parties have weakened and that public confidence in political leaders has diminished. This project will provide an authoritative test of these propositions. If they are established, it will identify the ways democratic governance can be renewed.Read moreRead less
How do Changes in Institutional Memory Affect Public Policy Processes? . This project will analyse how changes in institutional memory inside government impact on the effectiveness of public policy processes. Institutional memory changes as ministers, public servants and public agencies come and go, but we don’t know what effect these changes have over the quality of public policy. This project will therefore analyse how changes to institutional memory have influenced public services and polici ....How do Changes in Institutional Memory Affect Public Policy Processes? . This project will analyse how changes in institutional memory inside government impact on the effectiveness of public policy processes. Institutional memory changes as ministers, public servants and public agencies come and go, but we don’t know what effect these changes have over the quality of public policy. This project will therefore analyse how changes to institutional memory have influenced public services and policies in Australia and the UK. Expected outcomes include best practice recommendations for government - about how to address memory loss to improve public policy - and novel academic findings about how institutional memory influences the character of public service delivery, lesson-learning and long-term reform.Read moreRead less
Time and Politics: A Rapprochement of Analytic Political Philosophy and Post-structuralism. The most obvious benefits of this project will be academic, in that it will enrich contemporary political philosophy and advance theoretical work on the post-structuralism of Derrida and Deleuze. I will also be consulting with philosophers across Australia of both analytic and 'European' persuasion, and encouraging such a dialogue contributes to what is an emerging movement to break down the oppositional ....Time and Politics: A Rapprochement of Analytic Political Philosophy and Post-structuralism. The most obvious benefits of this project will be academic, in that it will enrich contemporary political philosophy and advance theoretical work on the post-structuralism of Derrida and Deleuze. I will also be consulting with philosophers across Australia of both analytic and 'European' persuasion, and encouraging such a dialogue contributes to what is an emerging movement to break down the oppositional thinking that has pervaded the Australian philosophical community. Finally, the findings of this project will also be used to instigate new ways of thinking regarding political issues afflicting Australians and the world, particularly in regard to refugees and reconciliation.
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Democratization and conflict management in Eastern Indonesia. The proposed project directly addresses the priority goal of understanding our region and the world to safeguard Australia. Indonesia is not only Australia's closest northern neighbour and the world's most populous Muslim nation, but also the third-largest democracy and the strategically most important country in Southeast Asia. The project will greatly enhance our understanding of some of the least known areas of Indonesia and is int ....Democratization and conflict management in Eastern Indonesia. The proposed project directly addresses the priority goal of understanding our region and the world to safeguard Australia. Indonesia is not only Australia's closest northern neighbour and the world's most populous Muslim nation, but also the third-largest democracy and the strategically most important country in Southeast Asia. The project will greatly enhance our understanding of some of the least known areas of Indonesia and is intended to prescribe concrete recommendations for the Australian government and aid organizations to assist them in their endeavours to promote democratization and help prevent and/or resolve communal conflict.Read moreRead less
Diatom lipids to reveal sea-ice history in remote Antarctic regions. This project aims to understand seasonal Antarctic sea-ice extent using molecular, geochemical, elemental and genomic characteristics of specific marine phytoplankton (diatoms). Little is known of the seasonal sea-ice variation and the position of the summer sea-ice extent a million years before satellite records, but this information is critical to determining air-sea gas exchange and ecosystem food web regulation. This projec ....Diatom lipids to reveal sea-ice history in remote Antarctic regions. This project aims to understand seasonal Antarctic sea-ice extent using molecular, geochemical, elemental and genomic characteristics of specific marine phytoplankton (diatoms). Little is known of the seasonal sea-ice variation and the position of the summer sea-ice extent a million years before satellite records, but this information is critical to determining air-sea gas exchange and ecosystem food web regulation. This project will unite geochemical and biological approaches to provide the data to improve past Antarctic ecosystem and climate models where sea-ice data is missing. Studying diatom biomarkers in deep sea cores from Australia’s Southern Ocean will redefine knowledge of Antarctic climate and provide data necessary to improve global ecosystem and climate models.Read moreRead less
A Buddhist Debate and Its Contemporary Relevance. The aim of this project is to engage with one of the central debates in Tibetan philosophy concerning truth, realism and epistemic justification. It plans to explore the implications of this debate for subsequent Tibetan thought and for contemporary Western analytic philosophy. The project plans to analyse previously unstudied texts and demonstrate the fecundity of a traditional method of collaborative cross-cultural philosophy today in which Tib ....A Buddhist Debate and Its Contemporary Relevance. The aim of this project is to engage with one of the central debates in Tibetan philosophy concerning truth, realism and epistemic justification. It plans to explore the implications of this debate for subsequent Tibetan thought and for contemporary Western analytic philosophy. The project plans to analyse previously unstudied texts and demonstrate the fecundity of a traditional method of collaborative cross-cultural philosophy today in which Tibetan and Western scholars work together to develop joint analyses. It may also demonstrate that the metaphysical and epistemological ideas and arguments developed in these debates can contribute to Western philosophy.Read moreRead less