Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply ....Real-time phylogenetics for food-borne outbreak surveillance. The project aims to introduce, for the first time, real-time evolutionary analysis of agricultural pathogens so that outbreaks affecting crops and the food supply can be managed precisely and rapidly. An expert team will implement a large-scale data analytics framework in user-friendly software that integrates Australian infectious disease genomics data with global data. Underpinning this work are new theory and algorithms that apply Sequential Monte Carlo to update phylogenetic analyses continuously as new data arrives. Expected outcomes include new knowledge of statistical algorithms for evolutionary analysis, relevant to biological disciplines beyond infectious disease; and enhanced capacity for infectious disease analysis. Read moreRead less
Asgard archaea: the first eukaryotic cells? . This project aims to uncover the role of unique microorganisms (Asgard archaea) in the origin of eukaryotes. These archaea may represent a ‘missing-link’ in eukaryotic evolution and are in abundance in the stromatolites in Shark Bay, Western Australia. Employing an innovative and interdisciplinary approach of cutting-edge molecular biology and high-resolution microscopy, this project expects to generate insights into fundamental aspects of evolution ....Asgard archaea: the first eukaryotic cells? . This project aims to uncover the role of unique microorganisms (Asgard archaea) in the origin of eukaryotes. These archaea may represent a ‘missing-link’ in eukaryotic evolution and are in abundance in the stromatolites in Shark Bay, Western Australia. Employing an innovative and interdisciplinary approach of cutting-edge molecular biology and high-resolution microscopy, this project expects to generate insights into fundamental aspects of evolution and cell biology. Expected outcomes include the discovery of unique branches of life and the proposal of new models for the emergence of eukaryotes. This research should allow for benefits across a spectrum of environmental and social gains, including improved ties with Indigenous communities.Read moreRead less
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
The role of proxy and governance advisers in corporate governance. This project analyses the role of proxy and governance advisers in corporate governance in Australia and the USA. Its outcomes will clarify the nature and extent of proxy and governance adviser influence over the conduct of institutional investors and listed companies, thus allowing for a more informed debate on the need for regulation.
The Politics of Transition in China, 1972-1982. The project provides a new interpretation of the elite politics behind one of the most remarkable transformations within a continuing political system in the late 20th century?the crucial period of transition between the radical late Mao era and the reform program of the 1980s. It thus examines several of the least researched, in any sustained in-depth sense, and, as a consequence, poorly understood periods of elite politics in the People's Republi ....The Politics of Transition in China, 1972-1982. The project provides a new interpretation of the elite politics behind one of the most remarkable transformations within a continuing political system in the late 20th century?the crucial period of transition between the radical late Mao era and the reform program of the 1980s. It thus examines several of the least researched, in any sustained in-depth sense, and, as a consequence, poorly understood periods of elite politics in the People's Republic of China.Read moreRead less
World Crime Fiction: Making Sense of a Global Genre. This project aims to generate new knowledge about the worldwide popularity of crime fiction by analysing the genre’s engagement with the major global challenges of our time, from climate change to the crisis of democracy. Using data from scholars and fans across all continents, and employing an innovative comparative methodology, it seeks to produce a new framework for analysing the global practice of crime fiction. Outcomes include a deeper u ....World Crime Fiction: Making Sense of a Global Genre. This project aims to generate new knowledge about the worldwide popularity of crime fiction by analysing the genre’s engagement with the major global challenges of our time, from climate change to the crisis of democracy. Using data from scholars and fans across all continents, and employing an innovative comparative methodology, it seeks to produce a new framework for analysing the global practice of crime fiction. Outcomes include a deeper understanding of the capacities of crime fiction to explore the complex relationship between crime, law and justice in various settings. The project will benefit Australia by creating new insights into the unique contribution of Australian, including Indigenous, crime writers to this truly global genre.Read moreRead less
One Day, We'll All Invest This Way! Regulating Online Investment. This project will provide policy recommendations to promote national research priority 3: particularly goals 4 & 5. It will do this by using good regulation to increase the safety of online investing services. It will bring to Australia international expertise not available here, crucial to good regulation of online investing. If investors trust this mostly beneficial technology it will further Australians' prosperity through in ....One Day, We'll All Invest This Way! Regulating Online Investment. This project will provide policy recommendations to promote national research priority 3: particularly goals 4 & 5. It will do this by using good regulation to increase the safety of online investing services. It will bring to Australia international expertise not available here, crucial to good regulation of online investing. If investors trust this mostly beneficial technology it will further Australians' prosperity through investment e.g. for retirement. Competitive advantage through good regulation will bring overseas investors to Australia through the Internet. It will consolidate its role as a financial centre. With 51% of adults owning shares, this research could save Australians more than $1.6 billion per annum! Read moreRead less
Shaping International Law in Global Transformations: Australian Experiences. This project aims to examine how Australia influences the development of international law in times of global transformation. The project proposes to develop a new analytical framework to understand how and why Australia has succeeded (or failed) in shaping the development of international law in four key periods of global transformation. Expected outcomes include empirical studies evaluating how, why and to what extent ....Shaping International Law in Global Transformations: Australian Experiences. This project aims to examine how Australia influences the development of international law in times of global transformation. The project proposes to develop a new analytical framework to understand how and why Australia has succeeded (or failed) in shaping the development of international law in four key periods of global transformation. Expected outcomes include empirical studies evaluating how, why and to what extent Australians managed to shape international law during these periods. These outcomes should provide benefits in the form of evidence-based proposals to enhance Australia's capacity to influence the development of international law in times of global transformation. Read moreRead less