New phylogenetic approaches for understanding evolution at the genome scale. This project aims to use genome data to improve our understanding of the evolutionary process, including the forces that shape evolution on a whole-genome scale. The project plans to create a curated database of genome sequences and a comprehensive framework for evolutionary analyses of genomes. The new approach is designed to be used to analyse patterns of evolutionary rate variation to identify the key features of gen ....New phylogenetic approaches for understanding evolution at the genome scale. This project aims to use genome data to improve our understanding of the evolutionary process, including the forces that shape evolution on a whole-genome scale. The project plans to create a curated database of genome sequences and a comprehensive framework for evolutionary analyses of genomes. The new approach is designed to be used to analyse patterns of evolutionary rate variation to identify the key features of genome evolution. In addition, the development of a genome-scale approach to molecular dating will improve estimates of the timescale of the Tree of Life. This project is expected to yield useful insights into molecular evolution and to provide a valuable guide for future evolutionary analyses of genomes.Read moreRead less
Directed evolution of ancestral bacterial flagellar motors. This project aims to produce new knowledge concerning the adaptation of bacterial species to wide environmental changes. The bacterial flagellar motor (BFM) is a motor 40 nanometers in diameter that builds itself into bacterial membranes, rotates five times faster than a Formula One engine, and switches directions in milliseconds. . This project will combine ancestral reconstruction of ancient motor components with protein engineering t ....Directed evolution of ancestral bacterial flagellar motors. This project aims to produce new knowledge concerning the adaptation of bacterial species to wide environmental changes. The bacterial flagellar motor (BFM) is a motor 40 nanometers in diameter that builds itself into bacterial membranes, rotates five times faster than a Formula One engine, and switches directions in milliseconds. . This project will combine ancestral reconstruction of ancient motor components with protein engineering to understand how the different ion channels that power the BFM in different species are selective for different positive ions. It will inspire and inform future manufacturing in bionanotechnology.Read moreRead less
The evolution of colour vision in vertebrates. Colour vision plays a crucial role in the lives of many animals including vertebrates. However, very little is known about the origins of colour vision and we aim to fill this gap. Photoreceptors (cone cells) with sensitivities to different colours mediate colour vision (humans possess blue, green and red cones). This study will examine the structure, physiological responses and molecular biology of these cells in the closest living relatives of the ....The evolution of colour vision in vertebrates. Colour vision plays a crucial role in the lives of many animals including vertebrates. However, very little is known about the origins of colour vision and we aim to fill this gap. Photoreceptors (cone cells) with sensitivities to different colours mediate colour vision (humans possess blue, green and red cones). This study will examine the structure, physiological responses and molecular biology of these cells in the closest living relatives of the early vertebrates. The underlying mechanisms for spectral tuning, the genetic rate of evolutionary change and the importance of colour in visual ecology will also be examined.Read moreRead less
Estimating evolutionary time-scales using genomic sequence data: exploiting opportunities and meeting challenges. Genomic data are being produced at a phenomenal rate, enabling detailed investigations of various biological questions. This project will exploit the new opportunities for improving the estimation of evolutionary time-scales, and develop methods and software to address the new challenges that have surfaced.
Improving access to phylogenomic resources for under-resourced species: a new look at existing tools. This project will have an impact on our understanding of how to most effectively use existing genomic resources to benefit a wider range of species and to better design new genomic resources. By doing so, improved access to genomic resources will be provided to species that currently have few options.
Australian Laureate Fellowships - Grant ID: FL170100008
Funder
Australian Research Council
Funding Amount
$3,248,822.00
Summary
Genes, reproduction and inheritance in a microbe. The project aims to particularly explore sexual gene inheritance in Plasmodium, a representative of a large group of human and animal parasites. Plasmodium must have a sexual exchange of genes in the mosquito for the transfer of disease to a new host. This project will investigate the fate and behaviour of Plasmodium genes during reproduction; the differing chromosome states resulting from sexual genetic processes and the asymmetrical inheritance ....Genes, reproduction and inheritance in a microbe. The project aims to particularly explore sexual gene inheritance in Plasmodium, a representative of a large group of human and animal parasites. Plasmodium must have a sexual exchange of genes in the mosquito for the transfer of disease to a new host. This project will investigate the fate and behaviour of Plasmodium genes during reproduction; the differing chromosome states resulting from sexual genetic processes and the asymmetrical inheritance of some Plasmodium genes. The project is expected to advance Australia’s ability to understand the reproduction and survival of these parasites in their mosquito vector and develop cutting-edge genetic tools that will advance the microbial genetics discipline globally. This may ultimately lead to biotechnology and biomedical outcomes.Read moreRead less
Refining the timescale of human evolution and dispersal using ancient DNA. Understanding the timescale of human evolution and migration is a key goal of genetic analysis. It provides the foundation for studying our evolutionary and demographic history, our relationships to other hominids and our impact on the natural world. This project aims to use ancient DNA data to improve estimates of our evolutionary timescale.
Further Genetic and Molecular studies of an Important Prokaryotic Regulator Protein TyrR. Genomes encode many functions whose expression varies dramatically depending on particular cellular environments. Special proteins called Regulator Proteins act as sensors to detect subtle changes in the environment and, in response, to influence the expression of certain genes either dampening them down or stimulating their activity. We are working with the TyrR regulator protein of the simple bacterium E ....Further Genetic and Molecular studies of an Important Prokaryotic Regulator Protein TyrR. Genomes encode many functions whose expression varies dramatically depending on particular cellular environments. Special proteins called Regulator Proteins act as sensors to detect subtle changes in the environment and, in response, to influence the expression of certain genes either dampening them down or stimulating their activity. We are working with the TyrR regulator protein of the simple bacterium Escherichia coli to elucidate the molecular strategies used in these controls. Because this protein controls the expression of a number of genes with diverse functions, evolution has selected equally diverse mechanisms to achieve appropriate transcriptional responses. The detailed knowledge of the E.coli genome and of the various genes regulated by TyrR make it an excellent system for such fundamental studies.Read moreRead less
Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management a ....Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management and conservation. This project links to large international initiatives currently underway for high-density mapping and sequencing of the eucalypt genome, to enhance the flow of information gained back to Australia for scientific, economic and environmental benefit.Read moreRead less
Testing links between genomic and morphological evolutionary rates. This project aims to identify, understand, and characterise patterns of evolutionary rates across different levels of biological variation. The project expects to generate knowledge about the tempo and mode of evolution by using a phylogenetic approach to test fundamental models of evolutionary rates, including the link between rates of genomic and morphological evolution. Expected outcomes of this project include detailed insig ....Testing links between genomic and morphological evolutionary rates. This project aims to identify, understand, and characterise patterns of evolutionary rates across different levels of biological variation. The project expects to generate knowledge about the tempo and mode of evolution by using a phylogenetic approach to test fundamental models of evolutionary rates, including the link between rates of genomic and morphological evolution. Expected outcomes of this project include detailed insights into the tempo and mode of macroevolution, better modelling of genomic and phenotypic evolution, and improved design of studies in evolutionary genomics. Benefits of the project include greater understanding of the evolutionary processes that have generated the diversity of the Australian biota.Read moreRead less