Linking genes with the phenotype - creation of a genetic linkage map for the silver-lipped pearl oyster Pinctada maxima. R&D undertaken in this project will increase our fundamental understanding of the role genetics plays in production of a premium quality cultured South Sea pearl. When utilised in future selective breeding programs aimed at improving pearl quality traits the information generated will allow Australian pearling companies to be more productive and to maintain a competitive advan ....Linking genes with the phenotype - creation of a genetic linkage map for the silver-lipped pearl oyster Pinctada maxima. R&D undertaken in this project will increase our fundamental understanding of the role genetics plays in production of a premium quality cultured South Sea pearl. When utilised in future selective breeding programs aimed at improving pearl quality traits the information generated will allow Australian pearling companies to be more productive and to maintain a competitive advantage over their rivals. Many rural communities are dependent on pearling companies for their economic prosperity and community identity. Consequently, positive growth of the pearl industry as a result of the proposed R&D will greatly benefit the economic and social wealth of these rural populations.Read moreRead less
Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and p ....Protecting while they prosper? Organisational responses to whistleblowing. This project aims to examine the adequacy of organisational responses to whistleblowing (employee reporting of wrongdoing). So far, research into public-interest whistleblowing has revealed much about the incidence, significance and experience of whistleblowers. This project now extends the research to the other side of the issue — the organisations. By comparing employee and managerial experience in multiple public and private sector organisations in Australia and New Zealand, the project intends to identify the factors that influence good and bad responses across a range of institutions; provide a clearer basis for reform of policies, procedures and law; and set benchmarks for comparative research worldwide.Read moreRead less
Strabismus is the pathological misalignment of the eyes associated with loss of binocular vision and is one of the most common human ophthalmological disorders. Patients with comitant strabismus have full eye movements, whereas patients with incomitant strabismus have limited eye movements, which causes the angle of strabismus to vary with gaze direction. This project aims to define genetic contributors to comitant congenital strabismus.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Understanding specificity and flexibility in coral symbioses. This project aims to understand why some corals can switch algal partners while others remain faithful to a single strain. This is important because corals depend on their symbiotic algal partners for survival and because some algae provide greater resilience to environmental stress than others. This project will greatly enhance our understanding of the molecular and physiological factors governing flexibility and specificity in coral ....Understanding specificity and flexibility in coral symbioses. This project aims to understand why some corals can switch algal partners while others remain faithful to a single strain. This is important because corals depend on their symbiotic algal partners for survival and because some algae provide greater resilience to environmental stress than others. This project will greatly enhance our understanding of the molecular and physiological factors governing flexibility and specificity in coral-algal symbioses. It will provide much-needed knowledge required to identify associations most appropriate for specific conditions, prioritise populations for conservation, and assess the feasibility of new approaches to managing and restoring coral reefs.
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The politics of public administration reform: capacity development and ideological contestation in international state-building. Why do expensive international aid programs often fail to achieve public administration reform in fragile states? This study investigates how the beliefs of public servants about the nature of their role reflect societal conflicts and alliances. Understanding this offers aid practitioners a means of designing tactical responses to reform agendas.
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Fertility crisis: harnessing the genomic tension behind pollen fertility in sorghum. Hybrid sorghum varieties yield more grain than inbred varieties but the production seed for farmers can be difficult. This project will identify the genes responsible for a trait that makes hybrid seed production possible and this knowledge will help raise sorghum yields in Australian and in some of the world’s poorest countries.