New phylogenetic approaches for understanding evolution at the genome scale. This project aims to use genome data to improve our understanding of the evolutionary process, including the forces that shape evolution on a whole-genome scale. The project plans to create a curated database of genome sequences and a comprehensive framework for evolutionary analyses of genomes. The new approach is designed to be used to analyse patterns of evolutionary rate variation to identify the key features of gen ....New phylogenetic approaches for understanding evolution at the genome scale. This project aims to use genome data to improve our understanding of the evolutionary process, including the forces that shape evolution on a whole-genome scale. The project plans to create a curated database of genome sequences and a comprehensive framework for evolutionary analyses of genomes. The new approach is designed to be used to analyse patterns of evolutionary rate variation to identify the key features of genome evolution. In addition, the development of a genome-scale approach to molecular dating will improve estimates of the timescale of the Tree of Life. This project is expected to yield useful insights into molecular evolution and to provide a valuable guide for future evolutionary analyses of genomes.Read moreRead less
Directed evolution of ancestral bacterial flagellar motors. This project aims to produce new knowledge concerning the adaptation of bacterial species to wide environmental changes. The bacterial flagellar motor (BFM) is a motor 40 nanometers in diameter that builds itself into bacterial membranes, rotates five times faster than a Formula One engine, and switches directions in milliseconds. . This project will combine ancestral reconstruction of ancient motor components with protein engineering t ....Directed evolution of ancestral bacterial flagellar motors. This project aims to produce new knowledge concerning the adaptation of bacterial species to wide environmental changes. The bacterial flagellar motor (BFM) is a motor 40 nanometers in diameter that builds itself into bacterial membranes, rotates five times faster than a Formula One engine, and switches directions in milliseconds. . This project will combine ancestral reconstruction of ancient motor components with protein engineering to understand how the different ion channels that power the BFM in different species are selective for different positive ions. It will inspire and inform future manufacturing in bionanotechnology.Read moreRead less
Estimating evolutionary time-scales using genomic sequence data: exploiting opportunities and meeting challenges. Genomic data are being produced at a phenomenal rate, enabling detailed investigations of various biological questions. This project will exploit the new opportunities for improving the estimation of evolutionary time-scales, and develop methods and software to address the new challenges that have surfaced.
Improving access to phylogenomic resources for under-resourced species: a new look at existing tools. This project will have an impact on our understanding of how to most effectively use existing genomic resources to benefit a wider range of species and to better design new genomic resources. By doing so, improved access to genomic resources will be provided to species that currently have few options.
Rerunning the evolution of an ancient bacterial propeller. This project aims to measure how the propeller which drives bacterial swimming originated and then evolved. This project expects to generate new knowledge in molecular evolution using interdisciplinary techniques in synthetic biology and biophysics to resurrect ancient proteins and test how they can be directed to evolve in a contemporary host. Expected outcomes include the development of new types of flagellar motor for applied uses in ....Rerunning the evolution of an ancient bacterial propeller. This project aims to measure how the propeller which drives bacterial swimming originated and then evolved. This project expects to generate new knowledge in molecular evolution using interdisciplinary techniques in synthetic biology and biophysics to resurrect ancient proteins and test how they can be directed to evolve in a contemporary host. Expected outcomes include the development of new types of flagellar motor for applied uses in synbio and microfluidics, and new methods to resurrect ancient proteins and evolve their function for purpose. This should provide significant benefits by delivering a de novo molecular motor for custom applications and galvanise public interest in how this iconic molecular complex originated and evolved.Read moreRead less
Genetic mechanisms of metabolic control and thermal sensing during thermoregulation. This research will significantly advance understanding of how animals can respond to climate change, and the results will benefit wildlife management processes. The proposed research will lead to collaboration with Prof. Ken Storey an ISI highly cited author and expert in microarray analysis. The cDNA microarray for Crocodylus porosus which I will construct in the proposed research will be a valuable resource ....Genetic mechanisms of metabolic control and thermal sensing during thermoregulation. This research will significantly advance understanding of how animals can respond to climate change, and the results will benefit wildlife management processes. The proposed research will lead to collaboration with Prof. Ken Storey an ISI highly cited author and expert in microarray analysis. The cDNA microarray for Crocodylus porosus which I will construct in the proposed research will be a valuable resource for Australia by increasing collaborations, and it will help find the cause of problems prevalent in the crocodile industry such as runt animals that significantly decrease production efficiency.Read moreRead less
1989 and the rule of law revolution. This project explores three elements of the post-1989 worldwide rule of law revolution: constitutionalism, 'dealing with the past', and rule of law promotion. Australia increasingly seeks to promote the rule of law internationally, but these efforts draw on an inadequate base of knowledge and theory. This project work will expand that base.
Bridling Autocrats: Limiting Executive Power in Authoritarian Polities. This project will analyse the dynamics of elite politics in authoritarian polities, focusing in particular upon how members of the elite try to constrain would-be dictators. By showing the different patterns of elite politics in different types of authoritarian systems, the project will interrogate one of the most curious aspects of contemporary international politics, why so many authoritarian regimes have been able to stab ....Bridling Autocrats: Limiting Executive Power in Authoritarian Polities. This project will analyse the dynamics of elite politics in authoritarian polities, focusing in particular upon how members of the elite try to constrain would-be dictators. By showing the different patterns of elite politics in different types of authoritarian systems, the project will interrogate one of the most curious aspects of contemporary international politics, why so many authoritarian regimes have been able to stabilise themselves in an era commonly seen as being one of democratic advance. Understanding authoritarian elite politics and their implications for regime survival is of significant policy interest.Read moreRead less
Strategies for the stabilisation of authoritarian rule: Russia in comparative perspective. This project will explore why authoritarian rule has been consolidated in post-Soviet Russia. By analysing this in a comparative context, the project will also explore why so many countries are characterised by non-democratic political systems in this so-called age of democracy.
Responses of reptiles to fluctuating thermal environments: behaviour or biochemistry? I propose a conceptual shift in the way thermal physiology of reptiles is interpreted, questioning the predominant role of behaviour in reptilian thermoregulation. I will test the hypothesis that changes in cellular biochemistry are an important mechanism by which reptiles respond to environmental fluctuations. I will determine the relationship between metabolic enzyme activity and performance functions, and ....Responses of reptiles to fluctuating thermal environments: behaviour or biochemistry? I propose a conceptual shift in the way thermal physiology of reptiles is interpreted, questioning the predominant role of behaviour in reptilian thermoregulation. I will test the hypothesis that changes in cellular biochemistry are an important mechanism by which reptiles respond to environmental fluctuations. I will determine the relationship between metabolic enzyme activity and performance functions, and the results may call for a re-assessment of current concepts such as the notion that reptiles must achieve "preferred" body temperatures to maintain performance.Read moreRead less