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Endoscopic Removal Of Lesions In The Gastrointestinal Tract
Funder
National Health and Medical Research Council
Funding Amount
$71,855.00
Summary
Barrett's oesophagus and flat colonic polyps are premalignant lesions with potential for progression to oesophageal and colorectal cancer, respectively. These cancers make up a signifiant portion of the burden of cancer disease in Australia. This research aims to improve outcomes of patients with Barrett's oesophagus and flat polyps by establishing the most appropriate treatment approach to Barrett's oesophagus, identifying risk factors that cause disease progression and by novel ways of enhanci ....Barrett's oesophagus and flat colonic polyps are premalignant lesions with potential for progression to oesophageal and colorectal cancer, respectively. These cancers make up a signifiant portion of the burden of cancer disease in Australia. This research aims to improve outcomes of patients with Barrett's oesophagus and flat polyps by establishing the most appropriate treatment approach to Barrett's oesophagus, identifying risk factors that cause disease progression and by novel ways of enhancing the technique of removal of polyps.Read moreRead less
Control Of Gastrointestinal Tumour Progression By Therapeutic Interference With Myeloid Derived Cells
Funder
National Health and Medical Research Council
Funding Amount
$758,678.00
Summary
Cancers of the stomach and the colon are a major health burden. Despite our increased molecular understanding of the mutation that cause these cancers our treatment options are very limited. Here we will use sophisticated and validated mouse models for these cancers to establish how blood-borne cells contribute to the growth and spreading of these cancer. We will use these models to establish highly effective treatment combinations of therapeutic agents that are already undergoing preclinical te ....Cancers of the stomach and the colon are a major health burden. Despite our increased molecular understanding of the mutation that cause these cancers our treatment options are very limited. Here we will use sophisticated and validated mouse models for these cancers to establish how blood-borne cells contribute to the growth and spreading of these cancer. We will use these models to establish highly effective treatment combinations of therapeutic agents that are already undergoing preclinical testing.Read moreRead less
Development Of Small Molecules For The Treament Of Colon Cancer
Funder
National Health and Medical Research Council
Funding Amount
$684,379.00
Summary
Colon cancer remains one of the leading causes of cancer related deaths in Australia and in the developed world. Despite improvements in prevention and therapies, there remains a considerable need for efficacious therapeutic options. We have identified a lead compound inhibiting the growth of cancer cells. We will progress this series further toward clinical trials and aim to provide patients with a new orally available molecule with potent activity against colon cancer.
Analysis Of APC And APC Protein Complexes In Colon Cancer
Funder
National Health and Medical Research Council
Funding Amount
$110,786.00
Summary
Colorectal cancer is one of the foremost causes of death in Australia. A defective form of a protein called APC has been shown to be present in more than 80% of colon tumours. How APC contributes to colon cancer is still not known. We aim to determine the function of the APC protein by studying the APC protein and proteins that interact with APC in normal and cancerous colon epithelial cells. We will use cells derived from normal colon epithelium as well as from colon carcinomas. Once we have id ....Colorectal cancer is one of the foremost causes of death in Australia. A defective form of a protein called APC has been shown to be present in more than 80% of colon tumours. How APC contributes to colon cancer is still not known. We aim to determine the function of the APC protein by studying the APC protein and proteins that interact with APC in normal and cancerous colon epithelial cells. We will use cells derived from normal colon epithelium as well as from colon carcinomas. Once we have identified proteins that interact with APC in normal colonic cells, we will have a more complete understanding of the function of APC and its role in the development of colonic tumours.Read moreRead less
The Roles Of EZH2 And FOXO1A In CNS-PNET Pathogenesis.
Funder
National Health and Medical Research Council
Funding Amount
$467,517.00
Summary
Although CNS-PNETs are the most common embryonal CNS tumours of childhood and cause significant mortality and morbidity, there is a very limited understanding of the pathogenesis of this aggressive disease. This situation is a major handicap to the development of more specific and effective therapies. While a better understanding of the fundamental pathology of CNS-PNETs will have immediate diagnostic implications, the elucidation of the biochemical pathways that are disrupted in these tumours w ....Although CNS-PNETs are the most common embryonal CNS tumours of childhood and cause significant mortality and morbidity, there is a very limited understanding of the pathogenesis of this aggressive disease. This situation is a major handicap to the development of more specific and effective therapies. While a better understanding of the fundamental pathology of CNS-PNETs will have immediate diagnostic implications, the elucidation of the biochemical pathways that are disrupted in these tumours will facilitate the design of new drugs that are specifically directed towards the critical proteins in these pathways. The identification of specific genes and-or pathways that are deregulated in CNS-PNET cells is essential for the development of safer, more directed, and more effective therapies that are urgently required for the treatment of those with this devastating disease.Read moreRead less
Rob Ramsay has had a long standing research commitment to understanding bowel and breast cancer using mouse models with defined genetic defects. These sophisticated models replicate various stages of cancer development and some have profound effects on normal tissue biology. He also uses molecular tools to investigate how genes are controlled. These approaches are providing direct input into the development of therapeutic agents for cancer treatment.
DOES BCL-G, A BH3-ONLY PROTEIN, PLAY A ROLE IN INFLAMMATION-ASSOCIATED COLON CANCER?
Funder
National Health and Medical Research Council
Funding Amount
$418,587.00
Summary
Deregulation of the function of several members of the Bcl-2 family has been shown to be an aggravating factor in autoimmune diseases and cancer. Bcl-G is a new and poorly characterized member of this family. We have produced essential tools to study the physiological function of Bcl-G, and discovered that it plays a role in inflammatory bowel disease. We now plan to investigate its possible role in inflammation-associated colon cancer.?
Sellar Masses, Pituitary Adenomas And Pathways Of Pituitary Tumourigenesis
Funder
National Health and Medical Research Council
Funding Amount
$90,917.00
Summary
Pituitary tumours encompass a number of pathologies. Their cause is not clearly established. Pituitary adenomas are one of the most frequent intracranial tumours. The genetics of sporadic tumours is unknown. Craniopharyngiomas are rare brain tumours arising in the pituitary stalk area that can have profound effects, presenting in childhood or later. To date there is limited knowledge on the cell signaling pathways causing these tumors, which can help to understand cancer in general.
Investigation Of DUSP5 As A Novel Tumour Suppressor Gene In Colon Cancer
Funder
National Health and Medical Research Council
Funding Amount
$578,268.00
Summary
Colon cancer is the second leading cause of cancer related death in Australia. Understanding the genetic causes of this disease are essential to developing new treatment strategies. The goal of this study is to understand the role of the DUSP5 gene in colon cancer. The findings of this study has the potential to further our understanding of how colon cancers arise and for identifying patients likely to respond to specific existing treatments.
Role Of The EHF Transcription Factor In Regulating The Differentiation Status Of Colon Cancers
Funder
National Health and Medical Research Council
Funding Amount
$621,950.00
Summary
New treatment strategies for colon cancer are urgently needed. This application will test a novel approach for treating colon cancer based on the re-induction of differentiation of colon cancer cells, by reactivating a gene called EHF. We expect this to reduce the propensity for colon cancer cells to spread to distant organs and to increase their sensitivity to chemotherpay. This has the potential to significantly benefit the clinical management of patients with this disease.