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Rob Ramsay has had a long standing research commitment to understanding bowel and breast cancer using mouse models with defined genetic defects. These sophisticated models replicate various stages of cancer development and some have profound effects on normal tissue biology. He also uses molecular tools to investigate how genes are controlled. These approaches are providing direct input into the development of therapeutic agents for cancer treatment.
Strategies For Enhancing The Treatment Of Colon Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$590,785.00
Summary
Colorectal cancer is the third leading cause of cancer related death in Australia. Strategies to improve outcomes for these patients are urgently needed. This NHMRC SRF Fellowship will seek to identify new molecules in cancer cells which can be targeted to treat this disease, and to discover genes which can be used to improve patient response to treatment.
Identification Of Novel Treatment Strategies For Human Cancers Through Integrative Phosphoproteomics And Kinomics.
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
This proposal aims to use new cutting-edge techniques to characterize, at a global level, changes in growth regulatory signals in cancer cells. This will identify proteins critical for cancer growth that represent potential targets for therapy. In addition it will highlight ways to select the most effective treatments for individual patients. The ultimate outcome of this work will be improved treatment strategies for cancer patients, and hence reduced morbidity and mortality.
The Population-health Science Of Sedentary Behaviour: An Integrated Approach To Understanding Environments, Prolonged Sitting And Adverse Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$1,009,478.00
Summary
Australians are ‘sitters’ -- at home, at work and in the car. Most do not do exercise, nor participate in sports. This leads to weight gain and risk of disease: notably type 2 diabetes, heart disease, breast and colon cancer. Professor Owen will identify why prolonged sitting can be so unhealthy; how our neighbourhoods, homes, work and cars make us sit too much; why some people are more susceptible to ‘couch potato’ lifestyles; and, the associated social and environmental impacts
Cancer is linked to mutations in a large variety of genes but how these changes impact on cell behaviour is often unknown. We are using functional genomics in zebrafish to identify genes that are essential for rapid rates of proliferation by intestinal epithelial cells. Seven genes have been cloned so far and our next task is to analyse, using mouse models and human cancer transcriptome analysis, whether any are indispensable for cancer growth and thereby present suitable targets for therapy.
Multiscale Analysis Of Plasma Membrane Microdomains In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$863,413.00
Summary
The cell surface encloses the cell in a protective barrier but it must also respond to signals coming from outside the cell. To accomplish this, the cell surface is made up of numerous regions each with a specialised role. This proposal aims to examine how lipids and proteins work together to make these specialised regions and aims to understand what goes wrong in diseases such as muscular dystrophy.
Malaria is a devastating disease of global significance. With mounting resistance to current drugs and no licensed malaria vaccine, there is a pressing need to search for new strategies to reduce the global burden of malaria. My research program aims to understand how the parasites that cause malaria extensively renovate the cells in which they reside and subvert their host so that they can thrive and survive, with a view to identifying new pathways that can be targeted by drugs or vaccines.
Structural Studies Of The Molecular Machinery Regulating Cell Death
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
Our bodies use a process called Programmed Cell Death to remove unwanted or dangerous cells. This work aims to understand the machinery that regulates this process at the molecular level. These insights will inform the development of drugs aimed at either initiating cell death when required, for example in cancer, or at inhibiting it when excessive cell death causes disease.
Manipulating Oncogenic-signalling Pathways In The Genesis And Treatment Of Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$601,484.00
Summary
Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The use of small molecule inhibitors is the most promising strategy for treating melanoma. In this project, we will examine the mechanisms of resistance to this class of drugs and define new drug targets by examining the molecular-circuitry is damaged in melanomas. This work will greatly accelerate the development of new therapi ....Melanoma is a major Australian health problem. It is the third most common cancer in men and women and has a disproportionately heavy impact on productive years of life. The use of small molecule inhibitors is the most promising strategy for treating melanoma. In this project, we will examine the mechanisms of resistance to this class of drugs and define new drug targets by examining the molecular-circuitry is damaged in melanomas. This work will greatly accelerate the development of new therapies.Read moreRead less