Discovery Early Career Researcher Award - Grant ID: DE140101071
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Does obesity alter the associations to food related cues, contexts and responses? Obesity is increasing dramatically in the developed world. The reasons for this are unclear, however the abundance of cheap, palatable food is clearly a contributing factor. Studies suggest differences arise in the processing of food rewards between overweight and lean individuals and the way they respond to food associated cues. This indicates that food associated cues may be more likely to evoke feeding behaviour ....Does obesity alter the associations to food related cues, contexts and responses? Obesity is increasing dramatically in the developed world. The reasons for this are unclear, however the abundance of cheap, palatable food is clearly a contributing factor. Studies suggest differences arise in the processing of food rewards between overweight and lean individuals and the way they respond to food associated cues. This indicates that food associated cues may be more likely to evoke feeding behaviours in absence of metabolic needs, therefore contributing to over eating that leads to obesity. This project will determine how rats, exposed to a model of our obesogenic western diet, process distinct cues and contexts associated with food rewards and control value driven responses to gain food rewards.Read moreRead less
Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as pred ....Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.Read moreRead less
Neural Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3
Funder
National Health and Medical Research Council
Funding Amount
$600,771.00
Summary
Dementia and mental illness are significant social and economic burdens worldwide and knowledge of underlying causes and more effective therapies are required. Our research is using preclinical models to characterize a little studied neural network in the control of arousal states, rhythmic brain activity, and learning and memory. Our findings could advance the development of improved treatments for cognitive deficits in degenerative, age-related and psychiatric disorders.
The impact of female sex hormones on neurodevelopment. This project aims to characterise the contribution of sex hormones to the development of emotional brain circuits in female adolescents. Puberty is associated with profound changes in emotional behaviours in females, but we know little about the underlying brain mechanisms. In particular, research has neglected to consider the role of the sex hormones for which changes are a defining feature of female puberty (eg, oestradiol). This work will ....The impact of female sex hormones on neurodevelopment. This project aims to characterise the contribution of sex hormones to the development of emotional brain circuits in female adolescents. Puberty is associated with profound changes in emotional behaviours in females, but we know little about the underlying brain mechanisms. In particular, research has neglected to consider the role of the sex hormones for which changes are a defining feature of female puberty (eg, oestradiol). This work will be the first to comprehensively advance our understanding of the unique role of sex hormones in shaping the adolescent female brain. It will provide critical understanding of how individual differences in hormonal factors increase risk for emotional problems in females, and inform treatment strategies.Read moreRead less
Ascending Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3 Transmission
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Mental illness and dementia are significant social and economic burdens worldwide and knowledge of their underlying causes and more effective therapies are required. Our research aims to use pre-clinical models to characterize a little studied neuronal network implicated in control of brain theta rhythm activity, which could lead to improved treatment of neuropsychiatric diseases such as anxiety and depression, and degenerative cognitive decline.
Relaxin-3/RXFP3 Signalling And Regulation Of Affective Behaviour _ Studies In Normal/transgenic Mice
Funder
National Health and Medical Research Council
Funding Amount
$578,268.00
Summary
Mental illness is a significant social and economic burden worldwide and knowledge of the underlying causes and more effective therapies are required. Our research aims to use pre-clinical animal models to characterize a little studied brain neuronal network implicated in control of arousal and stress, which could lead to improved treatment of psychiatric disorders such as depression.
The cognitive control of saccades: identifying neuroanatomical and neurophysiological substrates. This project will use imaging techniques to provide a greater understanding of neural processes underpinning the cognitive control of eye movement. As eye movements are often used as a measure cognition, understanding the functional organisation of the eye movement network, and the differences that predict how well a person performs, is crucial.
The advantage of being magnocellular: the role of the dorsal visual stream in object identification. The primary benefit of this project is to basic science and tertiary teaching globally. Visual processing and how it activates attention and operates to guide actions and cognitive behaviour is fundamental to our understanding of life and brain evolution. In particular this new knowledge will further understanding of many cognitive symptoms associated with neurodevelopmental disorders and in the ....The advantage of being magnocellular: the role of the dorsal visual stream in object identification. The primary benefit of this project is to basic science and tertiary teaching globally. Visual processing and how it activates attention and operates to guide actions and cognitive behaviour is fundamental to our understanding of life and brain evolution. In particular this new knowledge will further understanding of many cognitive symptoms associated with neurodevelopmental disorders and in the future should lead to design of better educational technologies for such children. Similarly understanding of temporal sequencing of vision has commercial implications for design of bionic eyes and robotic vision processing.Read moreRead less
Complexity in a mesoscopic model of brain dynamics. Research into how the brain work remains at the frontier of human knowledge. We possess only the vaguest idea how the brain is able to generate memories, perceptions and behaviour. This research proposal concerns new approaches aimed at bridging this gap in our understanding by developing and studying detailed theories of the brain's electrical activity. The outcomes of this work will not only suggest improved diagnostic methods and treatments ....Complexity in a mesoscopic model of brain dynamics. Research into how the brain work remains at the frontier of human knowledge. We possess only the vaguest idea how the brain is able to generate memories, perceptions and behaviour. This research proposal concerns new approaches aimed at bridging this gap in our understanding by developing and studying detailed theories of the brain's electrical activity. The outcomes of this work will not only suggest improved diagnostic methods and treatments but contribute vital knowledge about how to control and predict the behaviour of complex systems.Read moreRead less
An inability to resist a temptation or repeated failures of self-regulation can lead to 'impulsive' and 'compulsive' behaviours that relate to a host of personal and social problems (eg., excessive eating, gambling, and substance use). Despite this, very little research has studied the neural and psychological underpinnings of these behaviours. My research will take advantage of recent innovations and approaches to fill this void and have implications for diagnosis and treatment.