Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in ....Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in fear learning will enhance our ability to develop better therapeutic approaches for treating anxiety and preventing relapse, potentially through a gender-specific approach. The studies outlined in this proposal will have implications for promoting and maintaining good health.Read moreRead less
Electrophysiological correlates of verbal and visuospatial working memory. Successful interaction with the world is dependent on "working memory". This memory system holds things in mind, while relating them to the past and planning for the future. A carefully controlled task, presented on a computer screen, systematically increases the number of items to be kept in mind. Accuracy and speed of matching the items are measured. The results will contribute to a theory of what processes are used ....Electrophysiological correlates of verbal and visuospatial working memory. Successful interaction with the world is dependent on "working memory". This memory system holds things in mind, while relating them to the past and planning for the future. A carefully controlled task, presented on a computer screen, systematically increases the number of items to be kept in mind. Accuracy and speed of matching the items are measured. The results will contribute to a theory of what processes are used in working memory and how the human brain manages these processes.Read moreRead less
Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. T ....Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. The available tests provide information relevant to the later-stage of clinical depression only. In this regard, non-invasive and objective markers are urgently required to limit the burden of depression. In Australia, $3.3 billion in productivity and 12 million working days are lost each year as a result of depression.Read moreRead less
Gene-brain pathways in emotional brain stability and instability. Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combin ....Gene-brain pathways in emotional brain stability and instability. Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combination of gene-brain-behaviour markers which best capture emotional instability versus resilience. This evidence base will be crucial to developing new tools and strategies for early intervention, and ultimately prevention, for these conditions of mental health.Read moreRead less
The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
Dehumanization: Understanding the attribution of lesser humanness to others. The proposed research will contribute to an improved understanding of the subtle ways in which humanness is denied to members of some social groups. These processes contribute to intergroup antagonism and intolerance, and to a failure to take adequate moral account of other people's suffering. Understanding dehumanization can enhance our ability to recognize and overcome its manifestations in public life and the communi ....Dehumanization: Understanding the attribution of lesser humanness to others. The proposed research will contribute to an improved understanding of the subtle ways in which humanness is denied to members of some social groups. These processes contribute to intergroup antagonism and intolerance, and to a failure to take adequate moral account of other people's suffering. Understanding dehumanization can enhance our ability to recognize and overcome its manifestations in public life and the community. Scientifically, the proposed work will contribute to the nation's reputation as a world leader in the psychological study of intergroup relations.Read moreRead less
A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of ....A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of considerable benefits for the community as improved theories of the nature and causes of delusions generate strategies for earlier detection or even prevention of the development of delusions, new methods of therapy for patients, and better understanding for families.Read moreRead less
Exploring the link between group processes and outcomes of group psychotherapy. In Australia an estimated 20% of people suffer from mental disorders for which group psychotherapy is a treatment of choice. This project has the potential to deliver direct benefits to these patients by optimizing the way group psychotherapy is structured and delivered, thus reducing emotional suffering as well as reducing the cost of treatment. As a result, it would have tremendous implications for the treatment of ....Exploring the link between group processes and outcomes of group psychotherapy. In Australia an estimated 20% of people suffer from mental disorders for which group psychotherapy is a treatment of choice. This project has the potential to deliver direct benefits to these patients by optimizing the way group psychotherapy is structured and delivered, thus reducing emotional suffering as well as reducing the cost of treatment. As a result, it would have tremendous implications for the treatment of mental health problems nationally and internationally.Read moreRead less
Acquiring Social Fears in Infancy: Underlying Mechanisms and Implications for Behavioural Intervention. Social fears are wide-spread in the community and crippling for those affected. This study aims to (i) isolate parental behaviours and practices that result in elevated and persistent infant fear within social interactions, and (ii) establish the psychological mechanisms (e.g., observational learning) and temperamental features that underpin the transmission of social fears from mother to infa ....Acquiring Social Fears in Infancy: Underlying Mechanisms and Implications for Behavioural Intervention. Social fears are wide-spread in the community and crippling for those affected. This study aims to (i) isolate parental behaviours and practices that result in elevated and persistent infant fear within social interactions, and (ii) establish the psychological mechanisms (e.g., observational learning) and temperamental features that underpin the transmission of social fears from mother to infant. By elucidating the processes involved in the transmission of social fears, this investigation will enrich theories of emotional development in infancy, contribute to our understanding of serious conditions such as childhood shyness and Social Phobia, and provide an empirical basis for the development of effective methods of early intervention.Read moreRead less
Sleep and circadian influences on mood and Autonomic Nervous System control of the heart. Most biological and behavioural processes have a 24-hour oscillation in activity. A critical question is whether this oscillation is a consequence of the sleep-wake cycle or the circadian system (our internal biological clock). This project will investigate circadian influence over two biological systems that have important influences over behaviour, the Autonomic Nervous System (ANS) and the Behavioural Fa ....Sleep and circadian influences on mood and Autonomic Nervous System control of the heart. Most biological and behavioural processes have a 24-hour oscillation in activity. A critical question is whether this oscillation is a consequence of the sleep-wake cycle or the circadian system (our internal biological clock). This project will investigate circadian influence over two biological systems that have important influences over behaviour, the Autonomic Nervous System (ANS) and the Behavioural Facilitation System (BFS). Specifically, we will investigate the relationship between circadian control of the heart and the induction and quality of sleep, and the circadian influence on aspects of personality (neuroticism) and mood (Positive Affect) that are related to the BFS.Read moreRead less