The ability to monitor one's cognitive performance deteriorates with normal ageing, and is particularly affected in a range of clinical conditions of older age, such as Parkinson's Disease, where it is a predictor of a poor prognostic outcome. This project aims to clarify the effects of age on cognitive and neural processes underlying performance monitoring, as an important first step to improving interventions for age-related impairments, including those accompanying neurodegenerative diseases.
Neurocognitive Studies Of Reward Sensitivity In Opiate Addiction And Its Influence On Addiction-related Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$258,275.00
Summary
Drug abuse is the greatest single preventable risk factor for physical illness and death in Australians . Our understanding of the neural and cognitive mechanisms that contribute to the transition from drug use to addiction is not yet complete. The current proposal investigates cognitive control dysfunction, most notably the impulsivity for reward seen in drug addiction that is known to predict the transition from drug use to addiction and relapse during treatment.
Discovery Early Career Researcher Award - Grant ID: DE170100915
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Uncovering the dynamics of object selection from movement trajectories. This project aims to establish the dynamic properties of selection for perception and action, and develop a computational model of object selection across perception and action. Everyday actions depend on isolating the relevant object (perceptual selection) and appropriate grasp (action selection). It was long thought that distinct and sequential stages of processing carried out perceptual and action selection, but recent fi ....Uncovering the dynamics of object selection from movement trajectories. This project aims to establish the dynamic properties of selection for perception and action, and develop a computational model of object selection across perception and action. Everyday actions depend on isolating the relevant object (perceptual selection) and appropriate grasp (action selection). It was long thought that distinct and sequential stages of processing carried out perceptual and action selection, but recent findings suggested that a single mechanism may subserve both. Through a two-pronged approach including rigorous empirical work and computational modelling, this project aims to study this fundamental aspect of human cognition.Read moreRead less
Tracking the Flow of Perceptual Information Through Decision Networks. The choices we make define our lives. Despite exciting progress in neuroscience, we still don’t know how the inner workings of the brain give rise to simple decisions. This project brings together experts from diverse domains of computational neuroscience to investigate how our brains turn perceptual information into action. Together, we will develop new methods to track information flow through the brain during the decision ....Tracking the Flow of Perceptual Information Through Decision Networks. The choices we make define our lives. Despite exciting progress in neuroscience, we still don’t know how the inner workings of the brain give rise to simple decisions. This project brings together experts from diverse domains of computational neuroscience to investigate how our brains turn perceptual information into action. Together, we will develop new methods to track information flow through the brain during the decision making process. By doing so, we will develop a world-leading model of how the brain makes decisions, and also provide the broader scientific community with a set of exciting new tools for studying information processing in the brain.Read moreRead less
Spatial Learning And Memory In Huntington's Disease
Funder
National Health and Medical Research Council
Funding Amount
$475,969.00
Summary
This project will develop a spatial learning and memory test battery sensitive to dementia in Huntington’s disease, relate the task to atrophy in key brain regions, and then apply the test in a clinical trial aimed at developing a regeneration of damaged brain regions in Huntington’s disease. The overarching goal is to develop a cognitive test that is closely aligned to brain pathology in dementia as a tool for more precise, mechanism-based investigations in the dementia clinical trial setting.
A computational and experimental investigation into the organisation of letters in reading. In alphabetical languages, people need to learn to organise individual letters into groups so that they can read efficiently. This project will develop a model of this process, which will allow great insight into this key aspect of reading in terms of what the most efficient way of doing this is and what may go wrong and cause reading problems.
Mechanisms of learning at the interface between perception and action. Using the latest in brain imaging and simulator technology, this project will advance understanding of how experience shapes the visual centres of our brain. It will also support partnerships with construction, mining and health services by developing real and virtual machine interfaces and tools to enhance the outcome of simulator-based training.
Decoding the neural representation of objects in the human brain. Humans can effortlessly recognise thousands of objects in a fraction of a second. This essential capacity is an integral part of our daily lives that allows us to recognise our keys, our car, our friends and family. This project will elucidate how humans recognise objects by investigating the neural representation of objects in the brain.
Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This ....Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This project aims to build on recent discoveries of new stimuli to implement objective tests with which to study structure vision with the Partner Organisation. The project aims to also expand on realistic models of how Structure Vision may be computed by just a few coupled cortical pyramidal cells.Read moreRead less
Cortical regulation of attentional capture. The proposed experiments examine how brain mechanisms interact to determine whether a stimulus will capture our attention, distracting us from the task at hand. The experiments test competing theories of attentional control and have implications for clinical populations (for example, stroke) that have difficulty avoiding distraction.