The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.
Goal pursuit decisions under environmental and social uncertainty. This project aims to develop an integrative computational model that explains how people prioritise the allocation of resources to different goals in the face of uncertainty. The project seeks to test a new theory through a series of experiments in which participants pursue goals by themselves in unpredictable environments, or in competition against an opponent. Expected outcomes include an integrated theory that accounts for the ....Goal pursuit decisions under environmental and social uncertainty. This project aims to develop an integrative computational model that explains how people prioritise the allocation of resources to different goals in the face of uncertainty. The project seeks to test a new theory through a series of experiments in which participants pursue goals by themselves in unpredictable environments, or in competition against an opponent. Expected outcomes include an integrated theory that accounts for the effects of both environmental and social uncertainty in the pursuit of multiple goals. Intended benefits include the development of computational models that can simulate human decision making in complex environments, analyse new concepts of operation, redesign work roles, and identify factors that reduce risk in decision-making.Read moreRead less
Using diagnostic tests in science as formative assessment to enhance teaching and learning. The success and continuation of science programs in upper secondary school and university is dependent on foundational improvements in science education in lower secondary schools. This proposal is designed to address this national concern by fostering talent in science and encouraging more students to study and enjoy science in a meaningful way. Through planned formative assessment, teachers will enable ....Using diagnostic tests in science as formative assessment to enhance teaching and learning. The success and continuation of science programs in upper secondary school and university is dependent on foundational improvements in science education in lower secondary schools. This proposal is designed to address this national concern by fostering talent in science and encouraging more students to study and enjoy science in a meaningful way. Through planned formative assessment, teachers will enable students in Years 8-10 to think about the science concepts and consider alternative explanations rather than memorise basic facts for a test or examination which are then forgotten. Practical benefits are a large range of valid and reliable tests and a range of teaching approaches for diagnosing student learning difficulties.Read moreRead less
Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demand ....Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demands when dealing with multiple stimuli or performing multiple tasks concurrently under time pressure. The project aims to provide the basic research that is needed to extend psychological models of choice to complex ‘real-world’ tasks, such air traffic control and maritime surveillance.Read moreRead less
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Cognitive science: simulating the interactive evolution of human communication systems. We do not know how language first arose (the event left no trace), but it can be studied by simulating the circumstances under which new languages arise today. By having people play a game where they create new communication systems from scratch, this project will illuminate the origin of human language.
The Psychology of Misinformation—Towards A Theory-driven Understanding. The project aims to develop a psychological theory of misinformation effects. Misinformation influences people’s memory, reasoning and decision-making even after corrections – it thus poses a significant challenge for science and society. Through the combination of systematic experimentation with theory-driven computational modelling, the project will strive to concurrently consider individual-level cognition and the impact ....The Psychology of Misinformation—Towards A Theory-driven Understanding. The project aims to develop a psychological theory of misinformation effects. Misinformation influences people’s memory, reasoning and decision-making even after corrections – it thus poses a significant challenge for science and society. Through the combination of systematic experimentation with theory-driven computational modelling, the project will strive to concurrently consider individual-level cognition and the impact of sociocultural context. It is anticipated that this novel integrative approach will substantially expand our understanding of misinformation effects, and that this theoretical progress will result in the formulation of specific communication strategies to reduce the impact of misinformation on society.Read moreRead less
Developing a integrated memory-based model of evaluation and choice. People's judgements and choices are unstable. This project intends to examine one potential source of this instability: the memories that come to mind when people are evaluating choices. Many of the choices we make in our everyday lives are made on the basis of remembered information, and yet theories of evaluation and choice typically do not account for the role of memory, or provide only a cursory account of its role. In the ....Developing a integrated memory-based model of evaluation and choice. People's judgements and choices are unstable. This project intends to examine one potential source of this instability: the memories that come to mind when people are evaluating choices. Many of the choices we make in our everyday lives are made on the basis of remembered information, and yet theories of evaluation and choice typically do not account for the role of memory, or provide only a cursory account of its role. In the project, people will be presented with value information, and the project plans to examine how that information is retrieved from memory and then used to evaluate options and make decisions. Expected project outcomes would provide a coherent model that provides an integrated understanding of the role of memory in judgement and choice.Read moreRead less
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
The health effects of electronic cigarette use are virtually unknown. They have only recently been introduced into widespread use, and as such their effects on human health will not be known for many years. We will use our expertise in exposure models and health outcome measurement to provide timely hard-data on their potential to impact health – data that are urgently required to guide policy makers in this area.