Estimating And Alleviating The Impacts Of Age-Related Sensory Decline
Funder
National Health and Medical Research Council
Funding Amount
$323,767.00
Summary
Sensory loss and dementia disproportionately affect older adults, often co-occur, and are the two leading contributors to disability burden among older Australians. This research will investigate the consequences that hearing and vision loss have for older adult health and wellbeing, informing strategies to reduce the disability burden of age-related sensory loss. These impacts include cognitive decline and dementia, mental health, quality of life, disability and independent living.
A Scalable Intervention For Increasing Vigorous Physical Activity Among Older Adolescents: The ‘ Burn To Learn ’ Cluster RCT
Funder
National Health and Medical Research Council
Funding Amount
$636,912.00
Summary
Physical inactivity has been described as a global pandemic and only 15% of Australian adolescents are sufficiently active. The pressure to perform in major school assessments drives many older adolescents to sacrifice physical activity to maximise academic performance. Our team has designed a time-efficient solution to increase physical activity in senior high school students using high intensity interval training which will be evaluated using a cluster randomised controlled trial.
The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinemen ....The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinement of the brain's innate ability to generate predictions about the sensory environment. The resulting insights could improve understanding of neurodevelopmental disorders such as autism.Read moreRead less
Dynamics of word recognition: new insight from the reach-to-touch paradigm. This project will introduce a new behavioural reach-to-touch paradigm for studying basic cognitive processes such as word recognition. The advantage of this paradigm is that it is able to measure cognitive processes moment-by-moment as they unfold over time. This will provide new insights into the temporal dynamics of basic cognitive processing.
The Structural Basis For Glutamate Transporter Function
Funder
National Health and Medical Research Council
Funding Amount
$373,144.00
Summary
Glutamate transporters are vacuum cleaners in the brain that suck the neurotransmitter glutamate into cells. When the glutamate vacuum breaks down or becomes blocked, glutamate levels outside cells increase, leading to cell death in the brain. This process underlies the damage in many brain diseases including Alzheimer’s disease and stroke. The aim of this project is to understand the mechanism of the glutamate vacuum cleaner so we can develop therapeutics to fix it when it breaks down.
Risky Futures: Toward a Computational Process Model of Risky Inter-Temporal Choice. A lot is known about people’s preferences. People like their rewards now. Most would prefer $10 today than $20 in one month. Risk is also unattractive; a certain $10 is more attractive than a 50 per cent chance of receiving $25. Surprisingly, much less is known about the interaction between delay and risk. That is, relatively little is known about whether people prefer $10 now, or a 50 per cent chance of $50 in ....Risky Futures: Toward a Computational Process Model of Risky Inter-Temporal Choice. A lot is known about people’s preferences. People like their rewards now. Most would prefer $10 today than $20 in one month. Risk is also unattractive; a certain $10 is more attractive than a 50 per cent chance of receiving $25. Surprisingly, much less is known about the interaction between delay and risk. That is, relatively little is known about whether people prefer $10 now, or a 50 per cent chance of $50 in one month. This project will use a combination of experiments and cognitive modelling to examine all three types of choice. The outcome will be a novel computational model that will elucidate the complex interaction between delay and risk, thereby answering an enduring question in the literature: are risk and delay psychologically equivalent?Read moreRead less
External Therapeutic Device To Support Rehabilitation Of The Hand Following Trauma Or Surgery
Funder
National Health and Medical Research Council
Funding Amount
$175,000.00
Summary
The loss of hand function will affect every aspect of an individual’s life. This includes the ability to feed and care for themselves and the ability to work and participate in family life. For people recovering from problems such as trauma, burns or surgery affecting the hand, careful management of hand rehabilitation can influence the outcome for the patient significantly. In order to reduce the possibility of mobility difficulties occurring, including loss of joint range of motion, muscle and ....The loss of hand function will affect every aspect of an individual’s life. This includes the ability to feed and care for themselves and the ability to work and participate in family life. For people recovering from problems such as trauma, burns or surgery affecting the hand, careful management of hand rehabilitation can influence the outcome for the patient significantly. In order to reduce the possibility of mobility difficulties occurring, including loss of joint range of motion, muscle and tendon sheath adhesions or non-functional scar tissue formation, continuous passive motion (CPM) is often indicated. Additionally, for people with reduced mobility of the hand due to upper limb paralysis, such as those with cervical spinal cord injury, stroke, cerebral palsy or peripheral nerve injury, disregard for management of the maintenance of the joint range of motion of the effected hand will result in contracture and limited joint range of motion. Such syndromes will reduce hand function, which is already limited by paralysis, and will negatively affect potential outcomes for aggressive rehabilitation techniques, such as tendon transfer surgery and functional neuromuscular stimulation. Therefore, in such cases, CPM is also indicated. Current devices applying CPM have shown to be effective in minimising the syndromes indicated above and these results are summarised in the Background and Research Plan attached to this proposal. Unfortunately, the use of such devices is not always prescribed by clinicians. This is due, mainly, to the limitations of these devices that are in the marketplace. These limitations include lack of secure finger placement, lack of portability, the inability to provide specialised therapy to specific joints and inflexible programming. This proposal introduces an improved device to be developed and these improvements form the proposal aims below. Given such an improved device, which can overcome many of the problems with current CPM machines, it is likely that that the clinical application of CPM will achieve the greater degree of prescription and application in hand rehabilitation. These improvements should overcome the clinical reticence to use these devices and restore a balance by increasing their use to the level that the scientific literature indicates they should have. The overall aim of the proposal is to take the device to a stage where it is ready for clinical trial.Read moreRead less
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Unifying decisions from experience and description. The project aims to answer an enduring question: are separate theories required for decisions from experience and description? For some decisions, potential outcomes and probabilities are known – a gamble offering a 10 per cent chance to win $100 or a 90 per cent chance of nothing, for example. For many others, there is no ‘look-up table’ of probabilities and outcomes and so we must learn them via experience. Intriguingly, risky choices made on ....Unifying decisions from experience and description. The project aims to answer an enduring question: are separate theories required for decisions from experience and description? For some decisions, potential outcomes and probabilities are known – a gamble offering a 10 per cent chance to win $100 or a 90 per cent chance of nothing, for example. For many others, there is no ‘look-up table’ of probabilities and outcomes and so we must learn them via experience. Intriguingly, risky choices made on the basis of described or experienced information differ markedly. This project examines why this divergence occurs. The project plans to test an innovative approach that unifies both types of decisions into a single theoretical framework and provides a suite of empirical and modelling results.Read moreRead less
Toward a unified account of adaptive decision making: learning to search, stop and decide. The quality of decision making, our own and those with influence over us is a fundamental concern. The centrality of this issue means that it is crucial to understand the cognitive processes underlying human decision making. This project will deliver new insights into these processes and make key recommendations for improving decision making.