Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
Identifying Neuroimaging Based Biomarkers For Predicting Clinical Progression Along The Lewy Body Disease Spectrum
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Lewy body dementias (LBD) comprise similar but heterogenous group of poorly understood disabling neurodegenerative conditions. This project aims to apply advanced neuroimaging techniques and novel psychological testing to patients at risk of Lewy body disorders as well individuals with established disease to identify novel biomarkers that may explain symptoms of these disorders as well as help predict development of LBD at its early stages when it may be amenable to neuroprotective treatments.
Transdermal Testosterone Therapy: A Potential Treatment For Selective Serotonin Reuptake Inhibitor (SSRI)-associated Sexual Dysfunction In Women
Funder
National Health and Medical Research Council
Funding Amount
$241,351.00
Summary
Female sexual dysfunction (FSD) is frequently reported with selective serotonin reuptake inhibitor (SSRI) therapy and venlafaxine, these being the most common antidepressants used by Australian women. We have shown that testosterone therapy significantly improves sexual function in women with FSD. However SSRI-users have been excluded from these past studies. The aim of this study is to assess the efficacy of transdermal testosterone therapy for treatment of sexual dysfunction associated with SS ....Female sexual dysfunction (FSD) is frequently reported with selective serotonin reuptake inhibitor (SSRI) therapy and venlafaxine, these being the most common antidepressants used by Australian women. We have shown that testosterone therapy significantly improves sexual function in women with FSD. However SSRI-users have been excluded from these past studies. The aim of this study is to assess the efficacy of transdermal testosterone therapy for treatment of sexual dysfunction associated with SSRI therapy.Read moreRead less
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
A Nurse Led Psychosocial Intervention With Peer Support To Reduce Needs In Women Being Treated With Radiotherapy For Gynaecological Cancer: A RCT
Funder
National Health and Medical Research Council
Funding Amount
$1,184,630.00
Summary
This study is to test the effectiveness of a nurse-led psychosocial intervention with peer support to reduce psychological distress, psychosocial needs, psychosexual difficulties and symptom distress and to improve quality of life and preparation for treatment of women receiving radiotherapy with curative intent for gynaecological cancer (GC) using a randomised controlled trial (RCT).
Dynamics of word recognition: new insight from the reach-to-touch paradigm. This project will introduce a new behavioural reach-to-touch paradigm for studying basic cognitive processes such as word recognition. The advantage of this paradigm is that it is able to measure cognitive processes moment-by-moment as they unfold over time. This will provide new insights into the temporal dynamics of basic cognitive processing.
Risky Futures: Toward a Computational Process Model of Risky Inter-Temporal Choice. A lot is known about people’s preferences. People like their rewards now. Most would prefer $10 today than $20 in one month. Risk is also unattractive; a certain $10 is more attractive than a 50 per cent chance of receiving $25. Surprisingly, much less is known about the interaction between delay and risk. That is, relatively little is known about whether people prefer $10 now, or a 50 per cent chance of $50 in ....Risky Futures: Toward a Computational Process Model of Risky Inter-Temporal Choice. A lot is known about people’s preferences. People like their rewards now. Most would prefer $10 today than $20 in one month. Risk is also unattractive; a certain $10 is more attractive than a 50 per cent chance of receiving $25. Surprisingly, much less is known about the interaction between delay and risk. That is, relatively little is known about whether people prefer $10 now, or a 50 per cent chance of $50 in one month. This project will use a combination of experiments and cognitive modelling to examine all three types of choice. The outcome will be a novel computational model that will elucidate the complex interaction between delay and risk, thereby answering an enduring question in the literature: are risk and delay psychologically equivalent?Read moreRead less
Cross-comparison, Validation And Performance Of Computerised Neuropsychological Assessment Devices In The Evaluation Of Mild Cognitive Impairment And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$700,482.00
Summary
With an ageing population and associated increase in dementia there will be increased demand for neuropsychological assessment, with insufficient trained personnel and resources to meet this demand. Computerised tests offer excellent opportunities for large scale implementation of cognitive screening and monitoring of older adults. This is the first study to systematically evaluate and compare several popular computerised neuropsychological assessment devices in elders with and without dementia.
Comprehensive Clinical Tests Of Vestibular Function To Track Vestibular Compensation And Meniere’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$390,625.00
Summary
This Project will apply new, fast, safe, comprehensive, balance tests we have developed to measure the function of the balance receptors of the inner ear. We will track changes in balance function during disease and recovery in the many, and increasing, number of Australian patients with balance disorders. These tests will give us insight into changes in the inner ear associated with severe attacks of vertigo and why some patients recover so poorly after damage to inner ear balance receptors.
Unifying decisions from experience and description. The project aims to answer an enduring question: are separate theories required for decisions from experience and description? For some decisions, potential outcomes and probabilities are known – a gamble offering a 10 per cent chance to win $100 or a 90 per cent chance of nothing, for example. For many others, there is no ‘look-up table’ of probabilities and outcomes and so we must learn them via experience. Intriguingly, risky choices made on ....Unifying decisions from experience and description. The project aims to answer an enduring question: are separate theories required for decisions from experience and description? For some decisions, potential outcomes and probabilities are known – a gamble offering a 10 per cent chance to win $100 or a 90 per cent chance of nothing, for example. For many others, there is no ‘look-up table’ of probabilities and outcomes and so we must learn them via experience. Intriguingly, risky choices made on the basis of described or experienced information differ markedly. This project examines why this divergence occurs. The project plans to test an innovative approach that unifies both types of decisions into a single theoretical framework and provides a suite of empirical and modelling results.Read moreRead less