Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in ....Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in fear learning will enhance our ability to develop better therapeutic approaches for treating anxiety and preventing relapse, potentially through a gender-specific approach. The studies outlined in this proposal will have implications for promoting and maintaining good health.Read moreRead less
Concepts and control in speech production. While humans produce speech fluently in the course of everyday conversation, comparatively little is understood about the underlying mental processes and brain mechanisms. The overall aim of this project is to investigate how the human brain conceives and controls speech output by using state-of-the-art neuroimaging and brain stimulation techniques. The research aims to contribute novel insights into a key human ability with particular relevance for spe ....Concepts and control in speech production. While humans produce speech fluently in the course of everyday conversation, comparatively little is understood about the underlying mental processes and brain mechanisms. The overall aim of this project is to investigate how the human brain conceives and controls speech output by using state-of-the-art neuroimaging and brain stimulation techniques. The research aims to contribute novel insights into a key human ability with particular relevance for speech disorders such as aphasia, while the methods developed for brain stimulation during imaging of speech production aim to expand Australia's capability and technical innovation in the cognitive neuroscience of language.Read moreRead less
How the brain produces speech: Neuronal oscillations to neuromodulation. Speech is crucial for facilitating human communication through language, yet there is a lack of clarity about where, when and what type of activity occurs in the brain during key stages of production. This project will use intracranial recordings to characterise neuronal oscillations in combination with direct electrical stimulation, functional neuroimaging and non-invasive brain stimulation to establish critical areas and ....How the brain produces speech: Neuronal oscillations to neuromodulation. Speech is crucial for facilitating human communication through language, yet there is a lack of clarity about where, when and what type of activity occurs in the brain during key stages of production. This project will use intracranial recordings to characterise neuronal oscillations in combination with direct electrical stimulation, functional neuroimaging and non-invasive brain stimulation to establish critical areas and their timecourses with millisecond resolution. The outcome will be a better theoretical account of the brain mechanisms involved in spoken production. The benefit of this new theoretical account will be a better basis for prevention of post-surgical language impairment and neuromodulatory treatments after brain injury.Read moreRead less
A more sound approach to the neurobiology of language. How does the brain attain spoken language? Current neurobiological models assume either implicitly or explicitly that there is no relationship between a word's sound and its meaning. Yet considerable evidence shows this strong assumption about the arbitrariness of language is invalid. This project will use a combination of behavioural, neuroimaging and computational studies to characterise how the brain processes statistical regularities in ....A more sound approach to the neurobiology of language. How does the brain attain spoken language? Current neurobiological models assume either implicitly or explicitly that there is no relationship between a word's sound and its meaning. Yet considerable evidence shows this strong assumption about the arbitrariness of language is invalid. This project will use a combination of behavioural, neuroimaging and computational studies to characterise how the brain processes statistical regularities in sound-to-meaning correspondences as probabilistic cues to attain spoken language. The outcome will be a better neural account of language comprehension and production. The benefit of this new account will be a stronger basis for assessment and treatment of developmental and acquired language impairments.Read moreRead less
How does electrical stimulation affect brain networks? This project aims to generate fundamental knowledge about links between neural mechanisms, electrical brain stimulation and brain function. The project aims to improve knowledge about transcranial direct current stimulation (tDCS) and its effects on complex human brain networks. Such knowledge is necessary to enhance the effectiveness of current stimulation protocols. Using the innovative and interdisciplinary approach, this project will pr ....How does electrical stimulation affect brain networks? This project aims to generate fundamental knowledge about links between neural mechanisms, electrical brain stimulation and brain function. The project aims to improve knowledge about transcranial direct current stimulation (tDCS) and its effects on complex human brain networks. Such knowledge is necessary to enhance the effectiveness of current stimulation protocols. Using the innovative and interdisciplinary approach, this project will provide significant benefits such as crucial mechanistic information about how tDCS modulates healthy brain function which has broad implications for research and clinical use of this technique.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101290
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Age-related reorganisation of cortical networks subserving memory retrieval. This research project will use brain imaging to understand how the brain reorganises working memory when it ages. It will provide a framework for understanding age-related memory decline in the brain, which will in turn provide key information for understanding memory difficulties in clinical populations.
Goal pursuit decisions under environmental and social uncertainty. This project aims to develop an integrative computational model that explains how people prioritise the allocation of resources to different goals in the face of uncertainty. The project seeks to test a new theory through a series of experiments in which participants pursue goals by themselves in unpredictable environments, or in competition against an opponent. Expected outcomes include an integrated theory that accounts for the ....Goal pursuit decisions under environmental and social uncertainty. This project aims to develop an integrative computational model that explains how people prioritise the allocation of resources to different goals in the face of uncertainty. The project seeks to test a new theory through a series of experiments in which participants pursue goals by themselves in unpredictable environments, or in competition against an opponent. Expected outcomes include an integrated theory that accounts for the effects of both environmental and social uncertainty in the pursuit of multiple goals. Intended benefits include the development of computational models that can simulate human decision making in complex environments, analyse new concepts of operation, redesign work roles, and identify factors that reduce risk in decision-making.Read moreRead less
Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demand ....Modelling human decision making in complex environments. The project aims to extend quantitative psychological models of simple choice tasks to decision-making with complex stimuli in complex environments. The new formal models are designed to provide a comprehensive account of behaviour, including the choices that are made, how long it takes to make them, and how choices and choice times vary within and between decision-makers. The models would explain how people adapt to changes in task demands when dealing with multiple stimuli or performing multiple tasks concurrently under time pressure. The project aims to provide the basic research that is needed to extend psychological models of choice to complex ‘real-world’ tasks, such air traffic control and maritime surveillance.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101130
Funder
Australian Research Council
Funding Amount
$426,770.00
Summary
Beyond Response Time and Choice: Understanding Changes of Mind in Decisions. The project aims to provide novel experimental insight into how people change their minds during decisions, through identifying the cognitive architecture that reflects the behaviour that we observe from people. The project is significant because it provides a substantially deeper understanding of the cognitive decision process and how it changes over time, as opposed to previous research focusing on only the final resp ....Beyond Response Time and Choice: Understanding Changes of Mind in Decisions. The project aims to provide novel experimental insight into how people change their minds during decisions, through identifying the cognitive architecture that reflects the behaviour that we observe from people. The project is significant because it provides a substantially deeper understanding of the cognitive decision process and how it changes over time, as opposed to previous research focusing on only the final response that people make. The expected outcome is a comprehensive understanding of the human decision process through cognitive models that provide an accurate reflection of this mental process. The benefit is an improved understanding of decisions, which are a fundamental part of everyday human life.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100772
Funder
Australian Research Council
Funding Amount
$393,414.00
Summary
Response Time Constraints on Category Learning. Theories of associative learning and decision-making are among the most mathematically well developed in psychology. However, theories of learning do not account for the time course of decision-making, and theories of decision-making do not account for how decision-relevant information is learned. This project will develop an integrated theoretical framework linking core principles of associative learning theories with sequential sampling models of ....Response Time Constraints on Category Learning. Theories of associative learning and decision-making are among the most mathematically well developed in psychology. However, theories of learning do not account for the time course of decision-making, and theories of decision-making do not account for how decision-relevant information is learned. This project will develop an integrated theoretical framework linking core principles of associative learning theories with sequential sampling models of the time course of decision-making. The new theory will provide a quantitative account of how incremental associative learning processes drive changes in cognitive representations that, in turn, account for known changes in the time course of decision-making.Read moreRead less