IRAP inhibitors are currently being developed as a new class of drugs for treating dementia and other forms of memory deficits. However, there are still gaps in our knowledge about how these drugs act to improve memory. The experiments outlined in this proposal will provide important insights into the drug action in different mouse models of memory deficit.
The Genetic And Environmental Determinants Of Amyloid Deposition In Older Individuals: An Amyloid Imaging Study Using The Twin Design
Funder
National Health and Medical Research Council
Funding Amount
$643,267.00
Summary
Alzheimer’s disease is characterised by the deposition of amyloid plaques in the brain. We don’t fully understand how amyloid deposition occurs and what contribution is made by genetic and environmental factors. Amyloid deposition in the brain can now be quantified during life using positron emission tomography. In this study, we will examine brain amyloid in twins, which will determine what proportion of the pathology is attributable to environmental factors that may be modifiable.
Dementia Related Deficits In Striatal Cholinergic Function And Decision-making
Funder
National Health and Medical Research Council
Funding Amount
$414,370.00
Summary
This proposal will provide essential new information on the role of deficits in decision-making associated with Parkinson’s disease dementia. We will use an innovative animal model to assess the influence of neurodegeneration and neuroinflammation the consequent loss of function in the neuronal systems supporting the learning and memory processes that contribute to goal-directed action, particularly the way new learning interacts with existing memory to guide choice and decision-making.
Corpus callosum function in decision making. This project aims to investigate how the major connection between the two brain hemispheres (called the corpus callosum) is involved in higher cognitive functions such as decision making, learning, knowledge updating, and performance optimisation. New knowledge will be generated in the area of human cognition by combining computational theory with measures of cognition and brain MRI. Expected outcomes are to develop and advance computational models o ....Corpus callosum function in decision making. This project aims to investigate how the major connection between the two brain hemispheres (called the corpus callosum) is involved in higher cognitive functions such as decision making, learning, knowledge updating, and performance optimisation. New knowledge will be generated in the area of human cognition by combining computational theory with measures of cognition and brain MRI. Expected outcomes are to develop and advance computational models of human brain function and structure through interdisciplinary collaboration by combing theory and experimentation. Significant benefits will be to advance our understanding of the brain and enhance Australia's scientific capability through training and collaboration.Read moreRead less
How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at ....How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.Read moreRead less
The cognitive control of saccades: identifying neuroanatomical and neurophysiological substrates. This project will use imaging techniques to provide a greater understanding of neural processes underpinning the cognitive control of eye movement. As eye movements are often used as a measure cognition, understanding the functional organisation of the eye movement network, and the differences that predict how well a person performs, is crucial.
Developing A Pathophysiological Model For Attention Deficit Hyperactivity Disorder: A Path To Biomarker Discovery
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Despite the efficacy of stimulant medication in treating attention deficit hyperactivity disorder (ADHD), we lack mechanistic accounts of the neuropathology of ADHD. A major barrier is the lack of human disease models representing clinical symptoms. The derivation of a novel, cell-based ADHD model proposed in this project will shed new light on the physiological bases of ADHD and be a rich resource for biomarker discovery
The neuronal basis of visual consciousness: how brain rhythms control the doors of perception. Slow oscillatory brain wave activity may control the incoming flow of visual information from the world and modulate our perception. While recording neuronal activity directly from the brain, this project will modulate this rhythmic influence using novel visual illusions and brain stimulation techniques to control subjective visual perception.
Perceptual suppression mechanisms in the Drosophila brain. This project will investigate common processes underlying three means to losing conscious perception: selective attention, sleep and general anaesthesia. By studying these suppression mechanisms in a genetic model, the fly Drosophila melanogaster, fundamental processes will be highlighted that are required in the brain for maintaining perception in general.
Computational neuroanatomy: analysis of neural connections in the primate brain. This project will map the full network of connections between brain cells, using a computer graphics database that will consolidate data from hundreds of experiments. This will allow the first realistic simulations of neural activity, and will provide new insights about the structure and function of the nervous system.