Neural noise in human cognitive ageing and reserve. Age-related increases in neural noise degrade information transfer in the brain and lead to diminished cognitive function. Yet with cognitive reserve, some people are able to maintain healthy functioning well into their later years. This project aims to investigate the effects of neural noise on brain connectivity, cognitive performance and reserve, advancing breakthrough work on the neural physiology of healthy cognitive ageing and malleabilit ....Neural noise in human cognitive ageing and reserve. Age-related increases in neural noise degrade information transfer in the brain and lead to diminished cognitive function. Yet with cognitive reserve, some people are able to maintain healthy functioning well into their later years. This project aims to investigate the effects of neural noise on brain connectivity, cognitive performance and reserve, advancing breakthrough work on the neural physiology of healthy cognitive ageing and malleability of neural noise. This will be delivered by novel combinations of electrophysiology, neuroimaging and non-invasive brain stimulation. Benefits extend from developing neural markers for measuring cognitive reserve to new strategies for building resilience to age-related cognitive decline.Read moreRead less
The cognitive neuroscience of motor skill learning. The capacity to produce skilled motor behaviour is essential for success in almost every aspect of our lives, whether it be playing sport, driving a car, operating machinery at work, or touch-typing. This project aims to establish the causal role of brain regions in motor skill learning by combining cutting-edge techniques in neuroimaging and brain stimulation. It is expected to lead to fundamental new knowledge on how new motor memories are cr ....The cognitive neuroscience of motor skill learning. The capacity to produce skilled motor behaviour is essential for success in almost every aspect of our lives, whether it be playing sport, driving a car, operating machinery at work, or touch-typing. This project aims to establish the causal role of brain regions in motor skill learning by combining cutting-edge techniques in neuroimaging and brain stimulation. It is expected to lead to fundamental new knowledge on how new motor memories are created to enable the expression of skilled motor behaviour. The knowledge gained from this project may identify new strategies for learning skills that are widely applicable to education, industry, sport, and health.Read moreRead less
Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag str ....Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag strategies, ready for application in air travel. The project will directly inform Qantas’ operations for ultra-long haul flights and their international network more broadly. Project outcomes will benefit society and the economy through improving travellers’ alertness, sleep, and reducing the risk of fatigue-related accidents.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101087
Funder
Australian Research Council
Funding Amount
$453,580.00
Summary
Impact of shift work on emergency performance, decision making and stress. Sleep and circadian disruptions due to shift work are common for emergency personnel, but their impact on team performance and decision making is poorly understood. Using an ecologically relevant simulated work environment, this project aims to examine how shift work influences work performance and team decision making and identify potential stress-related mechanisms that may underpin impairments in these outcomes. By und ....Impact of shift work on emergency performance, decision making and stress. Sleep and circadian disruptions due to shift work are common for emergency personnel, but their impact on team performance and decision making is poorly understood. Using an ecologically relevant simulated work environment, this project aims to examine how shift work influences work performance and team decision making and identify potential stress-related mechanisms that may underpin impairments in these outcomes. By understanding the role poor sleep and circadian misalignment due to shift work play on work performance, this project will inform industry practices and training approaches designed to optimise workplace safety and emergency performance. This project will benefit emergency personnel and the people who depend on these services.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101348
Funder
Australian Research Council
Funding Amount
$470,999.00
Summary
Synergies between physical exercise, brain stimulation, and neuroplasticity. The brain is a highly dynamic organ. This capacity, known as neuroplasticity, governs our ability to learn new skills, acquire new knowledge, and fine-tune cognition. This project aims to investigate synergies between exercise, brain stimulation, and neuroplasticity, via application of a highly innovative interdisciplinary approach combining exercise physiology and cognitive neuroscience techniques. This project will pi ....Synergies between physical exercise, brain stimulation, and neuroplasticity. The brain is a highly dynamic organ. This capacity, known as neuroplasticity, governs our ability to learn new skills, acquire new knowledge, and fine-tune cognition. This project aims to investigate synergies between exercise, brain stimulation, and neuroplasticity, via application of a highly innovative interdisciplinary approach combining exercise physiology and cognitive neuroscience techniques. This project will pioneer novel, non-invasive methods of harnessing neuroplasticity to improve brain function, and generate fundamental insights into the mechanisms mediating learning and memory. Read moreRead less
The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinemen ....The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinement of the brain's innate ability to generate predictions about the sensory environment. The resulting insights could improve understanding of neurodevelopmental disorders such as autism.Read moreRead less
Drivers and constraints of romantic partner choice. This project aims to illuminate how genetic and environmental factors drive and constrain romantic partner choice. This choice can be the most significant in people’s lives, but how it works is not scientifically understood. This project will analyse the preferences and actual partners of thousands of twins using multivariable statistics and theoretic models of partner choice. The project aims to reveal why some people pair with incompatible pa ....Drivers and constraints of romantic partner choice. This project aims to illuminate how genetic and environmental factors drive and constrain romantic partner choice. This choice can be the most significant in people’s lives, but how it works is not scientifically understood. This project will analyse the preferences and actual partners of thousands of twins using multivariable statistics and theoretic models of partner choice. The project aims to reveal why some people pair with incompatible partners, and the consequences of partner mismatch for psychological wellbeing and for evolutionary processes driven by mate selection. This could lead to more effective relationship management.Read moreRead less
RNA structure prediction by deep learning and evolution-derived restraints. This project addresses the long-standing structure-folding problem of Ribonucleic acids (RNA) whose solution is essential for elucidating the roles of noncoding RNAs in living organisms. The proposed approach will detect hidden homologous sequences and enhance evolutionary covariation signals by developing new algorithms for search and smarter neural networks for deep learning. The project expects to generate new tools ....RNA structure prediction by deep learning and evolution-derived restraints. This project addresses the long-standing structure-folding problem of Ribonucleic acids (RNA) whose solution is essential for elucidating the roles of noncoding RNAs in living organisms. The proposed approach will detect hidden homologous sequences and enhance evolutionary covariation signals by developing new algorithms for search and smarter neural networks for deep learning. The project expects to generate new tools for structure-based probing of RNA evolutional and functional mechanisms. The outcomes should provide significant benefits by high-accuracy computational modelling of RNA structures that are difficult and costly to solve by current structural biology techniques but important for enabling biotech and clinical applications.Read moreRead less
Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected ....Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected outcomes include the refinement of social theory and capacity building via international collaboration and postgraduate training. This work will provide significant benefits by increasing our understanding of how the brain and social environment interact to moderate aggression and enhance social associations.Read moreRead less
The neurobiology of curiosity. This project aims to define the neurobiology of curiosity by combining cutting-edge techniques in computational modelling, pharmacointervention and neuroimaging. It is expected to lead to a comprehensive neuroscientific framework of curiosity, which will characterise its evolution over the lifespan, and its dependency on key neurotransmitter systems. Expected outcomes include a legacy of open access stimulus & data sets; the development of a global collaborative ne ....The neurobiology of curiosity. This project aims to define the neurobiology of curiosity by combining cutting-edge techniques in computational modelling, pharmacointervention and neuroimaging. It is expected to lead to a comprehensive neuroscientific framework of curiosity, which will characterise its evolution over the lifespan, and its dependency on key neurotransmitter systems. Expected outcomes include a legacy of open access stimulus & data sets; the development of a global collaborative network; and an increase in our national capacity and profile in decision neuroscience. The benefits of this project include laying the foundations for future interventions to improve curiosity, with potential downstream effects on many aspects of education, social & public policy.Read moreRead less