Transcriptional Regulation Of Gene Expression: Dietary Sialic Acid Interaction In Brain Cognitive Development
Funder
National Health and Medical Research Council
Funding Amount
$46,646.00
Summary
In 2004, 8.2% of Australian live births were preterm with poor long-term cognitive outcomes. Sialic acid (SA), a key component of both human milk oligosaccharides and neural tissues, plays a role in neuronal development. This study will examine the mechanisms of how dietary SA or active learning interacts with genes during brain development. It will benefit the neonatal care of all children, particularly those born premature and ultimately, the quality of life of many Australians.
A Cluster Randomised Trial To Test A Systems Based Collaborative For Type 2 Diabetes Among Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,855,936.00
Summary
Type 2 diabetes is a condition which contibutes significantly to Indigenous disability and premature death. Increasing numbers of Indigenous Australians are developing Type 2 diabetes. To date there has been limited research on systematic approaches to improving screening and managment outcomes for Type 2 diabetes. This important research will test the effectiveness of a systems based collaborative approach to improve health outcomes for people with Type 2 diabetes.
It is known that about 10% of patients over the age of 55 have difficulty with cognition and thinking 3 months after surgery and anaesthesia. Over 2 million operations involving anaesthesia are administered in Australia every year and increasingly the patients are elderly and thus exposed to the risk of cognitive decline after surgery. We have preliminary data showing that people who have mild changes in cognitive function before the surgery (known as mild cognitive impairment) are susceptible t ....It is known that about 10% of patients over the age of 55 have difficulty with cognition and thinking 3 months after surgery and anaesthesia. Over 2 million operations involving anaesthesia are administered in Australia every year and increasingly the patients are elderly and thus exposed to the risk of cognitive decline after surgery. We have preliminary data showing that people who have mild changes in cognitive function before the surgery (known as mild cognitive impairment) are susceptible to further cognitive decline after anaesthesia and surgery. In order to explore the relationship between preoperative cognitive function and postoperative cognitive decline we plan to measure cognition in patients scheduled for elective hip replacement surgery. This is done by asking patients to complete a standard battery of cognitive tests. We will be then able to identify those patients who already have mild cognitive impairment before surgery and by repeated testing after the operation will be able to demonstrate if preoperative cognitive status is a determinant of postoperative cognitive dysfunction. The primary aim of the research is to test whether cognitive impairment before surgery leads to cognitive deficit after surgery in patients over the age of 65 undergoing total hip replacement surgery. The study will also establish the prevalence of pre-operative mild cognitive impairment and the magnitude of postoperative cognitive dysfunction after surgery in this patient group. The study will explore the relationship between preoperative cognitive status and postoperative cognitive deficit , providing information about the incidence, natural history and risk factors of postoperative cognitive deficit. This work will enable further research to isolate specific causative factors and identify therapeutic and prophylactic strategies.Read moreRead less
Fighting Mental Disorders: Using Mental Imagery To Disarm Symptoms And Enhance Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
This proposal will conduct the first pre-clinical and clinical research utilising mental imagery to disarm symptoms and enhance treatment of multiple mental disorders by controlling the strength of mental imagery. This fellowship represents the first attempt to alleviate symptoms by developing a cognitive-neuroscience method to control the strength of traumatic imagery and to show a causative means of enhancing imagery strength to boost the success rate of cognitive therapy involving imagery.
Cardiac Intervention, Surgery And Cognitive Outcome (CISCO) Study
Funder
National Health and Medical Research Council
Funding Amount
$367,739.00
Summary
We propose to investigate the association between the presence of coronary artery disease and changes in brain function after therapeutic interventions. Patients undergoing surgery for coronary heart disease are prone to experience changes in mental function and higher level thought processes (cognition) after surgery, especially if they are elderly. As the population ages this is becoming a more significant problem. There is some limited evidence that this particular group of patients has a hig ....We propose to investigate the association between the presence of coronary artery disease and changes in brain function after therapeutic interventions. Patients undergoing surgery for coronary heart disease are prone to experience changes in mental function and higher level thought processes (cognition) after surgery, especially if they are elderly. As the population ages this is becoming a more significant problem. There is some limited evidence that this particular group of patients has a higher incidence of cognitive impairment than the normal population even before they present for surgery, because cardiovascular disease has also been shown to be associated with changes in cognition. To investigate this, we will measure cognitive status in patients over the age of 55 who have coronary artery disease and are being investigated with coronary angiography. This will provide an indication of the baseline cognitive status in patients presenting with coronary vascular disease. We will use validated neuropsychological tests that have been used to assess potsoperative cognitive decline. These tests are sufficiently sensitive to detect subtle changes in a number of areas of thought processing (cognitive domains) and thus identify those subjects who have cognitive impairment. Patients will then go on to be treated by surgery or angioplasty. We will continue to test these patients at time intervals for 3 months in order to track the changes in cognition in each treatment group. Thus we will be in the position to compare how these modalities of treatment for heart disease impact on patients mental function and cognition. In addition we will be able to tell whether a 'recovery' period might be of benefit following coronary angiography. If we are able to demonstrate different cognitive outcomes from different treatments and also an association with pre-existing cognition, this will guide clinical decision making to minimise harm to the brain.Read moreRead less
The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinemen ....The development of predictive brain function in preschool children. This project aims to track developmental changes in brain activity and connectivity in typically developing three-to-six year-old children. The preschool years are a time of huge change in children's cognitive abilities, but little is known of the corresponding changes in brain function. This work will use child-optimised magnetoencephalography to test the hypothesis that early cognitive development is characterised by refinement of the brain's innate ability to generate predictions about the sensory environment. The resulting insights could improve understanding of neurodevelopmental disorders such as autism.Read moreRead less
Dynamics of word recognition: new insight from the reach-to-touch paradigm. This project will introduce a new behavioural reach-to-touch paradigm for studying basic cognitive processes such as word recognition. The advantage of this paradigm is that it is able to measure cognitive processes moment-by-moment as they unfold over time. This will provide new insights into the temporal dynamics of basic cognitive processing.
Investigations Into The Onset And Persistence Of Severe Health Anxiety (hypochondriasis), And The Development Of Innovative Psychological Interventions
Funder
National Health and Medical Research Council
Funding Amount
$313,096.00
Summary
This program of research will investigate the cognitive, emotional, and behavioural factors that are involved in the onset and persistence of severe health anxiety (hypochondriasis). It will also test the effectiveness of innovative psychological interventions for the disorder.