This research is directed by a team of medical and basic scientists with expertise in mechanisms of inflammation relevant to human disease. The program will investigate the molecular and cellular events that are responsible for inflammation in the kidneys, joints and blood vessels which lead to diseases such as glomerulonephritis, arthritis and atherosclerosis. The aim of the research is to find new therapeutic targets which may be specific to certain organs or disease processes, in order to dev ....This research is directed by a team of medical and basic scientists with expertise in mechanisms of inflammation relevant to human disease. The program will investigate the molecular and cellular events that are responsible for inflammation in the kidneys, joints and blood vessels which lead to diseases such as glomerulonephritis, arthritis and atherosclerosis. The aim of the research is to find new therapeutic targets which may be specific to certain organs or disease processes, in order to develop more effective and selective treatments ofchronic inflammatory disease in humans.Read moreRead less
Elimination of the transplant waiting list is the ultimate goal of research into pigto-human xenotransplantation. The prospect of success has been improved recently by refinements in technology used to introduce genetic modifications in the pig, although the genes that will need to be expressed or deleted are still undecided. What is clear is that intravascular thrombosis, a critical mediator of rejection of pig xenografts, must be overcome. This project aims to investigate the use of anticoagul ....Elimination of the transplant waiting list is the ultimate goal of research into pigto-human xenotransplantation. The prospect of success has been improved recently by refinements in technology used to introduce genetic modifications in the pig, although the genes that will need to be expressed or deleted are still undecided. What is clear is that intravascular thrombosis, a critical mediator of rejection of pig xenografts, must be overcome. This project aims to investigate the use of anticoagulant gene expression to prevent intravascular thrombosis associated with xenograft rejection.Read moreRead less