Developing And Applying Statistical Genetics Methods To Identify Genes, Molecular Biomarkers And Environmental Agents That Causally Affect Risk Of Complex Musculoskeletal Diseases
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
My aim is to identify genes, biological molecules and environmental factors that causally affect risk of osteoporosis and ankylosing spondylitis (a form of autoimmune arthritis) using novel and existing statistical genetics methodologies. My research will advance understanding of the causes of these diseases, identify new opportunities for their treatment, and provide the scientific community with new statistical methods and software to identify factors that causally influence risk of disease.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and ....Tuning parallel applications on software-defined supercomputers. Supercomputers are used by many Australian industries and laboratories to make better products and perform critical predictions, and it is essential that codes operate efficiently. This project aims to assist programmers in identifying performance bottlenecks in their code quickly and easily. The project expects to supersede the current methods, which are often complex and time-consuming, by developing innovative software tools and techniques. The expected outcomes include novel software, verified by industry partners in real world case studies, ranging from life sciences to hypersonic transport. This should provide significant benefits, including the capacity for Australian industries to access world-class supercomputing technology.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastru ....An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastructure is central to the control of such attacks and hence to a nation's long-term survival and prosperity. The outcomes of this project can be directly used in Australian research communities and adopted by industry and government agencies.Read moreRead less
Software debuggers for next generation heterogeneous supercomputers. Supercomputing underpins a wide range of areas of importance to the Australian economy; mining, agriculture, engineering and medical research to name a few. It is of critical importance that software solutions in these areas behave correctly. This project will develop software tools and techniques to help locate errors in such applications.
Design and Development of a Web-based Intelligent Multimedia Mining System. Increasing amounts of digital multimedia data in the form of video is being captured and stored. However, even the most advanced storage and retrieval techniques lack the features required to be used singly, or in combination, to fulfil a wide range of user needs and rapid access to multimedia resources, even in a very large video database. The core challenges are indeed to develop efficient, smart and intelligent web-ba ....Design and Development of a Web-based Intelligent Multimedia Mining System. Increasing amounts of digital multimedia data in the form of video is being captured and stored. However, even the most advanced storage and retrieval techniques lack the features required to be used singly, or in combination, to fulfil a wide range of user needs and rapid access to multimedia resources, even in a very large video database. The core challenges are indeed to develop efficient, smart and intelligent web-based multimedia mining in Australia and elsewhere. In this project, we will explore techniques and develop algorithms for content-based multimedia retrieval and mining in multimedia databases.Read moreRead less
Mapping Trusted Systems Technologies to E-security Requirements. A new software based approach, strongly guided by national and international security standards based upon mandatory access control, is required to simplify for management the protection of their information infrastructure. This will be in the form of a security definition toolset aligned to trusted systems technologies currently under consideration internationally. No such trusted system has been developed to address current comme ....Mapping Trusted Systems Technologies to E-security Requirements. A new software based approach, strongly guided by national and international security standards based upon mandatory access control, is required to simplify for management the protection of their information infrastructure. This will be in the form of a security definition toolset aligned to trusted systems technologies currently under consideration internationally. No such trusted system has been developed to address current commercial IT product environments. The safety and security of information systems against attack and illicit usage form an essential component of ?National Information Infrastructure Protection (NIIP)?, a move to better ?e-security?. Existing commercial (untrusted) operating systems lack the critical security bases for e-security making e-applications vulnerable to tampering and bypass which can cause failures in overall system security.Read moreRead less
A Novel Framework for Optimised Ensemble Classifier. The project aims to develop a novel framework for creating an optimised ensemble classifier that will improve data analysis and the accuracy of many real-world applications such as document analysis, robotics and medical diagnosis. The project plans to develop and investigate novel methods for generating diverse training environment layers, base classifiers and fusion of classifiers. It also plans to design a multi-objective evolutionary algor ....A Novel Framework for Optimised Ensemble Classifier. The project aims to develop a novel framework for creating an optimised ensemble classifier that will improve data analysis and the accuracy of many real-world applications such as document analysis, robotics and medical diagnosis. The project plans to develop and investigate novel methods for generating diverse training environment layers, base classifiers and fusion of classifiers. It also plans to design a multi-objective evolutionary algorithm-based search obtain the optimal number of layers, clusters and base classifiers. The expected outcomes of the proposed framework are advances in classifier learning. The final outcome may be novel methods which will bring in diversity during the learning of the base classifiers and provide an optimal ensemble classifier for real-world applications.Read moreRead less